Effects of single subanesthetic dose of oxycodone on pain and Th1/Th2 balance in patients after radical mastectomy
Objective To compare the effects of oxycodone and fentanyl on postoperative pain relief，immune balance of T-helper cells（Th），and adverse reactions in radical mastectomy. Methods A total of 120 female patients whounderwent elective radical mastectomy at Shanghai Public Health Clinical Center between...
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The Editorial Department of Chinese Journal of Clinical Research
2025-06-01
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| Series: | Zhongguo linchuang yanjiu |
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| author | QU Na，ZHAO Xiaohong，NI Qiang |
| author_facet | QU Na，ZHAO Xiaohong，NI Qiang |
| author_sort | QU Na，ZHAO Xiaohong，NI Qiang |
| collection | DOAJ |
| description | Objective To compare the effects of oxycodone and fentanyl on postoperative pain relief，immune balance of T-helper cells（Th），and adverse reactions in radical mastectomy. Methods A total of 120 female patients whounderwent elective radical mastectomy at Shanghai Public Health Clinical Center between December 2021 and January2024 were selected for this study. They were randomly divided into two groups using a random number table：the observation group（oxycodone group）and the control group（fentanyl group），with 60 patients in each group. The combined intravenous-inhalation general anesthesia were performed in both groups. During anesthesia induction，the observation group received an intravenous injection of oxycodone hydrochloride（0.1 mg/kg），and the control group received an intravenous injection of fentanyl citrate（1.0 μg/kg）. Both groups received remifentanil for maintenance during surgery. Postoperative visual analog scale（VAS）scores，Th1 and Th2 levels were recorded at 1，6，12，24，and 48 hours post-surgery. Differences in VAS scores between the groups were analyzed using a difference -in-differences（DID）model，and repeated measurement ANOVA was used for Th1，Th2，and Th1/Th2 levels. A quintile group analysis was performed to explore the relationship between Th1/Th2 levels and the risk of postoperative pain. Adverse reactions in both groups were analyzed using log-binomial regression. Results （1）The postoperative VAS scores of both groups decreased with the prolongation of time（1 h→6 h→12 h→24 h→48 h）（P<0.05），and the VAS score of the observation group was lower than that of the control group at each time point after operation（P<0.05）.（2）The results of the DID model analysis showed significant differences in VAS scores based on group，time，and the group × time interaction（P<0.01）.（3）The postoperative Th1/Th2 ratio of the two groups increased in the intra-group effect analysis（time factor）. The observation group had a significantly better Th1/Th2 ratio at 1，6，12，24，and 48 hours post-surgery compared to the control group（inter-group principal effect analysis）. The Th1/Th2 ratio continued to show a significant improvement in the observation group over time compared to the control group （inter-group × time interaction）.（4）Logistic regression analysis revealed that different Th1/Th2 levels were independently associated with postoperative pain（P<0.01）.（5）Compared to the control group，the observation group had a significantly lower risk of overall adverse reactions（RR=0.342，95%CI：0.146-0.783，P<0.05）. Conclusion The use of oxycodone during radical mastectomy can enhance postoperative analgesia，promote Th1/Th2 immune balance，and reduce the incidence of adverse reactions compared to fentanyl. |
| format | Article |
| id | doaj-art-8c1d1237c12f49d8a08dde17c2da0459 |
| institution | DOAJ |
| issn | 1674-8182 |
| language | zho |
| publishDate | 2025-06-01 |
| publisher | The Editorial Department of Chinese Journal of Clinical Research |
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| spelling | doaj-art-8c1d1237c12f49d8a08dde17c2da04592025-08-20T03:16:17ZzhoThe Editorial Department of Chinese Journal of Clinical ResearchZhongguo linchuang yanjiu1674-81822025-06-01386875879，88910.13429/j.cnki.cjcr.2025.06.013Effects of single subanesthetic dose of oxycodone on pain and Th1/Th2 balance in patients after radical mastectomyQU Na，ZHAO Xiaohong，NI Qiang0Department of Anesthesiology，Shanghai Public Health Clinical Center，Shanghai 201508，ChinaObjective To compare the effects of oxycodone and fentanyl on postoperative pain relief，immune balance of T-helper cells（Th），and adverse reactions in radical mastectomy. Methods A total of 120 female patients whounderwent elective radical mastectomy at Shanghai Public Health Clinical Center between December 2021 and January2024 were selected for this study. They were randomly divided into two groups using a random number table：the observation group（oxycodone group）and the control group（fentanyl group），with 60 patients in each group. The combined intravenous-inhalation general anesthesia were performed in both groups. During anesthesia induction，the observation group received an intravenous injection of oxycodone hydrochloride（0.1 mg/kg），and the control group received an intravenous injection of fentanyl citrate（1.0 μg/kg）. Both groups received remifentanil for maintenance during surgery. Postoperative visual analog scale（VAS）scores，Th1 and Th2 levels were recorded at 1，6，12，24，and 48 hours post-surgery. Differences in VAS scores between the groups were analyzed using a difference -in-differences（DID）model，and repeated measurement ANOVA was used for Th1，Th2，and Th1/Th2 levels. A quintile group analysis was performed to explore the relationship between Th1/Th2 levels and the risk of postoperative pain. Adverse reactions in both groups were analyzed using log-binomial regression. Results （1）The postoperative VAS scores of both groups decreased with the prolongation of time（1 h→6 h→12 h→24 h→48 h）（P<0.05），and the VAS score of the observation group was lower than that of the control group at each time point after operation（P<0.05）.（2）The results of the DID model analysis showed significant differences in VAS scores based on group，time，and the group × time interaction（P<0.01）.（3）The postoperative Th1/Th2 ratio of the two groups increased in the intra-group effect analysis（time factor）. The observation group had a significantly better Th1/Th2 ratio at 1，6，12，24，and 48 hours post-surgery compared to the control group（inter-group principal effect analysis）. The Th1/Th2 ratio continued to show a significant improvement in the observation group over time compared to the control group （inter-group × time interaction）.（4）Logistic regression analysis revealed that different Th1/Th2 levels were independently associated with postoperative pain（P<0.01）.（5）Compared to the control group，the observation group had a significantly lower risk of overall adverse reactions（RR=0.342，95%CI：0.146-0.783，P<0.05）. Conclusion The use of oxycodone during radical mastectomy can enhance postoperative analgesia，promote Th1/Th2 immune balance，and reduce the incidence of adverse reactions compared to fentanyl.http://zglcyj.ijournals.cn/zglcyj/ch/reader/create_pdf.aspx?file_no=20250613oxycodonesubanesthetic dose，singlepostoperative paint ⁃ helper cell 1/t ⁃ helper cell 2immune balanceradical mastectomy |
| spellingShingle | QU Na，ZHAO Xiaohong，NI Qiang Effects of single subanesthetic dose of oxycodone on pain and Th1/Th2 balance in patients after radical mastectomy Zhongguo linchuang yanjiu oxycodone subanesthetic dose，single postoperative pain t ⁃ helper cell 1/t ⁃ helper cell 2 immune balance radical mastectomy |
| title | Effects of single subanesthetic dose of oxycodone on pain and Th1/Th2 balance in patients after radical mastectomy |
| title_full | Effects of single subanesthetic dose of oxycodone on pain and Th1/Th2 balance in patients after radical mastectomy |
| title_fullStr | Effects of single subanesthetic dose of oxycodone on pain and Th1/Th2 balance in patients after radical mastectomy |
| title_full_unstemmed | Effects of single subanesthetic dose of oxycodone on pain and Th1/Th2 balance in patients after radical mastectomy |
| title_short | Effects of single subanesthetic dose of oxycodone on pain and Th1/Th2 balance in patients after radical mastectomy |
| title_sort | effects of single subanesthetic dose of oxycodone on pain and th1 th2 balance in patients after radical mastectomy |
| topic | oxycodone subanesthetic dose，single postoperative pain t ⁃ helper cell 1/t ⁃ helper cell 2 immune balance radical mastectomy |
| url | http://zglcyj.ijournals.cn/zglcyj/ch/reader/create_pdf.aspx?file_no=20250613 |
| work_keys_str_mv | AT qunazhaoxiaohongniqiang effectsofsinglesubanestheticdoseofoxycodoneonpainandth1th2balanceinpatientsafterradicalmastectomy |