Measurement of Photoreceptor Layer in Glaucoma: A Spectral-Domain Optical Coherence Tomography Study
Objective. To measure and compare photoreceptor layer thickness between normal and glaucomatous eyes using spectral-domain optical coherence tomography (OCT). Methods. Thirty-eight healthy normal volunteers and 47 glaucoma patients were included in the analysis. One eye from each participant was ra...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2011/264803 |
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| _version_ | 1832549111892541440 |
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| author | Ning Fan Nina Huang Dennis Shun Chiu Lam Christopher Kai-shun Leung |
| author_facet | Ning Fan Nina Huang Dennis Shun Chiu Lam Christopher Kai-shun Leung |
| author_sort | Ning Fan |
| collection | DOAJ |
| description | Objective. To measure and compare photoreceptor layer thickness between normal and glaucomatous eyes using spectral-domain optical coherence tomography (OCT).
Methods. Thirty-eight healthy normal volunteers and 47 glaucoma patients were included in the analysis. One eye from each participant was randomly selected for macula imaging by a spectral-domain OCT (3D OCT-1000, Topcon, Tokyo, Japan). The foveal and parafoveal (1.5 mm from the fovea) outer nuclear layer (ONL) and inner and outer segments (IS+OS) layer thicknesses were measured by a single masked observer. The measurements were repeated 3 times in a random sample of 30 normal eyes to determine the repeatability coefficient and intraclass correlation coefficient.
Results. The measurement variabilities of photoreceptor thickness were low. The respective intraclass correlation coefficients of ONL and IS+OS thicknesses were 0.96 (95% confidence interval: 0.94–0.98) and 0.82 (95% confidence interval 0.70–0.90). While there were no differences in parafoveal ONL and IS+OS thicknesses between normal and glaucoma groups (𝑃≤.410), the foveal ONL thickness was greater in glaucomatous eyes (𝑃=.011) than in normal eyes.
Conclusions. Glaucomatous damage may involve structural change in the photoreceptor layer. |
| format | Article |
| id | doaj-art-8c19cfbe7ef34b31a5f311562140c41f |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-8c19cfbe7ef34b31a5f311562140c41f2025-02-03T06:12:09ZengWileyJournal of Ophthalmology2090-004X2090-00582011-01-01201110.1155/2011/264803264803Measurement of Photoreceptor Layer in Glaucoma: A Spectral-Domain Optical Coherence Tomography StudyNing Fan0Nina Huang1Dennis Shun Chiu Lam2Christopher Kai-shun Leung3Department of Ophthalmology and Visual Sciences, Hong Kong Eye Hospital, The Chinese University of Hong Kong, 147K Argyle Street, Kowloon, Hong KongShenzhen Eye Hospital, Jinan University, Shenzhen 518001, ChinaDepartment of Ophthalmology and Visual Sciences, Hong Kong Eye Hospital, The Chinese University of Hong Kong, 147K Argyle Street, Kowloon, Hong KongDepartment of Ophthalmology and Visual Sciences, Hong Kong Eye Hospital, The Chinese University of Hong Kong, 147K Argyle Street, Kowloon, Hong KongObjective. To measure and compare photoreceptor layer thickness between normal and glaucomatous eyes using spectral-domain optical coherence tomography (OCT). Methods. Thirty-eight healthy normal volunteers and 47 glaucoma patients were included in the analysis. One eye from each participant was randomly selected for macula imaging by a spectral-domain OCT (3D OCT-1000, Topcon, Tokyo, Japan). The foveal and parafoveal (1.5 mm from the fovea) outer nuclear layer (ONL) and inner and outer segments (IS+OS) layer thicknesses were measured by a single masked observer. The measurements were repeated 3 times in a random sample of 30 normal eyes to determine the repeatability coefficient and intraclass correlation coefficient. Results. The measurement variabilities of photoreceptor thickness were low. The respective intraclass correlation coefficients of ONL and IS+OS thicknesses were 0.96 (95% confidence interval: 0.94–0.98) and 0.82 (95% confidence interval 0.70–0.90). While there were no differences in parafoveal ONL and IS+OS thicknesses between normal and glaucoma groups (𝑃≤.410), the foveal ONL thickness was greater in glaucomatous eyes (𝑃=.011) than in normal eyes. Conclusions. Glaucomatous damage may involve structural change in the photoreceptor layer.http://dx.doi.org/10.1155/2011/264803 |
| spellingShingle | Ning Fan Nina Huang Dennis Shun Chiu Lam Christopher Kai-shun Leung Measurement of Photoreceptor Layer in Glaucoma: A Spectral-Domain Optical Coherence Tomography Study Journal of Ophthalmology |
| title | Measurement of Photoreceptor Layer in Glaucoma: A Spectral-Domain Optical Coherence Tomography Study |
| title_full | Measurement of Photoreceptor Layer in Glaucoma: A Spectral-Domain Optical Coherence Tomography Study |
| title_fullStr | Measurement of Photoreceptor Layer in Glaucoma: A Spectral-Domain Optical Coherence Tomography Study |
| title_full_unstemmed | Measurement of Photoreceptor Layer in Glaucoma: A Spectral-Domain Optical Coherence Tomography Study |
| title_short | Measurement of Photoreceptor Layer in Glaucoma: A Spectral-Domain Optical Coherence Tomography Study |
| title_sort | measurement of photoreceptor layer in glaucoma a spectral domain optical coherence tomography study |
| url | http://dx.doi.org/10.1155/2011/264803 |
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