Associations between Macular OCT Angiography and Nonproliferative Diabetic Retinopathy in Young Patients with Type 1 Diabetes Mellitus
Background/Objective. Optical coherence tomography angiography (OCTA) is increasingly used to supplement ophthalmoscopy in the diagnosis and follow-up of diabetic retinopathy. Our objective was to confirm if OCTA parameters can predict the development of nonproliferative diabetic retinopathy (NPDR)...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2020/8849116 |
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| author | Nina C. B. B. Veiby Aida Simeunovic Martin Heier Cathrine Brunborg Naila Saddique Morten C. Moe Knut Dahl-Jørgensen Hanna D. Margeirsdottir Goran Petrovski |
| author_facet | Nina C. B. B. Veiby Aida Simeunovic Martin Heier Cathrine Brunborg Naila Saddique Morten C. Moe Knut Dahl-Jørgensen Hanna D. Margeirsdottir Goran Petrovski |
| author_sort | Nina C. B. B. Veiby |
| collection | DOAJ |
| description | Background/Objective. Optical coherence tomography angiography (OCTA) is increasingly used to supplement ophthalmoscopy in the diagnosis and follow-up of diabetic retinopathy. Our objective was to confirm if OCTA parameters can predict the development of nonproliferative diabetic retinopathy (NPDR) and to clarify if any single OCTA parameter is associated with NPDR independently of well-known risk factors in young type 1 diabetes (T1D) patients. Methods. OCTA of both eyes was performed in a cross-sectional study of 14 to 30-year-old individuals with at least 10-year duration of T1D and controls recruited from the Norwegian Atherosclerosis and Childhood Diabetes (ACD) study. Vessel density (VD) and foveal avascular zone (FAZ) area in the superficial and deep capillary plexus (SCP and DCP), total retinal volume (TRV), and central macular thickness (CMT) were calculated using automated software. Univariate and multivariate ordered logistic regression (OLR) models were used accordingly. Results. We included 168 control eyes and 315 T1D eyes. Lower VD in DCP (OR 0.65, 95% CI 0.51–0.83), longer diabetes duration (OR 1.51, 95% CI 1.22–1.87), and higher waist circumference (OR 1.08, 95% CI 1.02–1.14) were significantly associated with progression of NPDR. VD in SCP and DCP were significantly lower in T1D patients without diabetic retinopathy than in controls. Conclusions. Sparser VD in DCP is significantly associated with severity of NPDR, supporting that OCTA might detect the earliest signs of NPDR before it is visible by ophthalmoscopy. |
| format | Article |
| id | doaj-art-8c0f510063844e98823f9ec6aaac3d1e |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-8c0f510063844e98823f9ec6aaac3d1e2025-02-03T01:08:11ZengWileyJournal of Diabetes Research2314-67452314-67532020-01-01202010.1155/2020/88491168849116Associations between Macular OCT Angiography and Nonproliferative Diabetic Retinopathy in Young Patients with Type 1 Diabetes MellitusNina C. B. B. Veiby0Aida Simeunovic1Martin Heier2Cathrine Brunborg3Naila Saddique4Morten C. Moe5Knut Dahl-Jørgensen6Hanna D. Margeirsdottir7Goran Petrovski8Center for Eye Research, Department of Ophthalmology, Oslo University Hospital, 0407 Oslo, NorwayDepartment of Paediatrics and Adolescent Medicine, Akershus University Hospital, 1474 Lorenskog, NorwayDepartment of Paediatric Medicine, Oslo University Hospital, 0407 Oslo, NorwayOslo Centre of Biostatistics and Epidemiology, Oslo University Hospital, 0372 Oslo, NorwayCenter for Eye Research, Department of Ophthalmology, Oslo University Hospital, 0407 Oslo, NorwayCenter for Eye Research, Department of Ophthalmology, Oslo University Hospital, 0407 Oslo, NorwayDepartment of Paediatric Medicine, Oslo University Hospital, 0407 Oslo, NorwayDepartment of Paediatric Medicine, Oslo University Hospital, 0407 Oslo, NorwayCenter for Eye Research, Department of Ophthalmology, Oslo University Hospital, 0407 Oslo, NorwayBackground/Objective. Optical coherence tomography angiography (OCTA) is increasingly used to supplement ophthalmoscopy in the diagnosis and follow-up of diabetic retinopathy. Our objective was to confirm if OCTA parameters can predict the development of nonproliferative diabetic retinopathy (NPDR) and to clarify if any single OCTA parameter is associated with NPDR independently of well-known risk factors in young type 1 diabetes (T1D) patients. Methods. OCTA of both eyes was performed in a cross-sectional study of 14 to 30-year-old individuals with at least 10-year duration of T1D and controls recruited from the Norwegian Atherosclerosis and Childhood Diabetes (ACD) study. Vessel density (VD) and foveal avascular zone (FAZ) area in the superficial and deep capillary plexus (SCP and DCP), total retinal volume (TRV), and central macular thickness (CMT) were calculated using automated software. Univariate and multivariate ordered logistic regression (OLR) models were used accordingly. Results. We included 168 control eyes and 315 T1D eyes. Lower VD in DCP (OR 0.65, 95% CI 0.51–0.83), longer diabetes duration (OR 1.51, 95% CI 1.22–1.87), and higher waist circumference (OR 1.08, 95% CI 1.02–1.14) were significantly associated with progression of NPDR. VD in SCP and DCP were significantly lower in T1D patients without diabetic retinopathy than in controls. Conclusions. Sparser VD in DCP is significantly associated with severity of NPDR, supporting that OCTA might detect the earliest signs of NPDR before it is visible by ophthalmoscopy.http://dx.doi.org/10.1155/2020/8849116 |
| spellingShingle | Nina C. B. B. Veiby Aida Simeunovic Martin Heier Cathrine Brunborg Naila Saddique Morten C. Moe Knut Dahl-Jørgensen Hanna D. Margeirsdottir Goran Petrovski Associations between Macular OCT Angiography and Nonproliferative Diabetic Retinopathy in Young Patients with Type 1 Diabetes Mellitus Journal of Diabetes Research |
| title | Associations between Macular OCT Angiography and Nonproliferative Diabetic Retinopathy in Young Patients with Type 1 Diabetes Mellitus |
| title_full | Associations between Macular OCT Angiography and Nonproliferative Diabetic Retinopathy in Young Patients with Type 1 Diabetes Mellitus |
| title_fullStr | Associations between Macular OCT Angiography and Nonproliferative Diabetic Retinopathy in Young Patients with Type 1 Diabetes Mellitus |
| title_full_unstemmed | Associations between Macular OCT Angiography and Nonproliferative Diabetic Retinopathy in Young Patients with Type 1 Diabetes Mellitus |
| title_short | Associations between Macular OCT Angiography and Nonproliferative Diabetic Retinopathy in Young Patients with Type 1 Diabetes Mellitus |
| title_sort | associations between macular oct angiography and nonproliferative diabetic retinopathy in young patients with type 1 diabetes mellitus |
| url | http://dx.doi.org/10.1155/2020/8849116 |
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