Dietary peptides in aging: Evidence and prospects
With improvements in healthcare and lifestyle, the proportion of the aging population is rising steadily across the world. Many physiological functions are altered during aging and resemble those occurring in disease conditions involving metabolic and mitochondrial disturbances. Thus, there is an ur...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tsinghua University Press
2020-03-01
|
| Series: | Food Science and Human Wellness |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453019302150 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832544351531565056 |
|---|---|
| author | Khushwant S. Bhullar Jianping Wu |
| author_facet | Khushwant S. Bhullar Jianping Wu |
| author_sort | Khushwant S. Bhullar |
| collection | DOAJ |
| description | With improvements in healthcare and lifestyle, the proportion of the aging population is rising steadily across the world. Many physiological functions are altered during aging and resemble those occurring in disease conditions involving metabolic and mitochondrial disturbances. Thus, there is an urge to better develop dietary or medicinal interventions targeting the mechanisms underlying aging and aging-related diseases. Many reports indicate that in geroscience, dietary interventions such as bioactive peptides to slow aging are a matter of 'when' rather than 'if'. Leading targets for peptides include the metabolic-mitochondrial pathway accompanied by improved nutrient sensing. Modulation of these pathways diminish aging biomarkers in various model organisms and confers protection against a growing list of age-related pathophysiologies. Food derived bioactive peptides are characterized modulators of these pathways, while some verified in vivo and even clinically approved, and numerous others are under development. This brief review focuses on the latest scientific advances in understanding the anti-aging ability of bioactive peptides as well as delineates the possible future directions in this process. Keywords: Dietary peptides, Anti-aging, Aging biomarkers |
| format | Article |
| id | doaj-art-8c0980cbd60d49619fc703a1e8a864b1 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2020-03-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-8c0980cbd60d49619fc703a1e8a864b12025-02-03T10:36:31ZengTsinghua University PressFood Science and Human Wellness2213-45302020-03-019117Dietary peptides in aging: Evidence and prospectsKhushwant S. Bhullar0Jianping Wu1Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada; Department of Pharmacology, University of Alberta, Edmonton, AB, CanadaDepartment of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada; Corresponding author.With improvements in healthcare and lifestyle, the proportion of the aging population is rising steadily across the world. Many physiological functions are altered during aging and resemble those occurring in disease conditions involving metabolic and mitochondrial disturbances. Thus, there is an urge to better develop dietary or medicinal interventions targeting the mechanisms underlying aging and aging-related diseases. Many reports indicate that in geroscience, dietary interventions such as bioactive peptides to slow aging are a matter of 'when' rather than 'if'. Leading targets for peptides include the metabolic-mitochondrial pathway accompanied by improved nutrient sensing. Modulation of these pathways diminish aging biomarkers in various model organisms and confers protection against a growing list of age-related pathophysiologies. Food derived bioactive peptides are characterized modulators of these pathways, while some verified in vivo and even clinically approved, and numerous others are under development. This brief review focuses on the latest scientific advances in understanding the anti-aging ability of bioactive peptides as well as delineates the possible future directions in this process. Keywords: Dietary peptides, Anti-aging, Aging biomarkershttp://www.sciencedirect.com/science/article/pii/S2213453019302150 |
| spellingShingle | Khushwant S. Bhullar Jianping Wu Dietary peptides in aging: Evidence and prospects Food Science and Human Wellness |
| title | Dietary peptides in aging: Evidence and prospects |
| title_full | Dietary peptides in aging: Evidence and prospects |
| title_fullStr | Dietary peptides in aging: Evidence and prospects |
| title_full_unstemmed | Dietary peptides in aging: Evidence and prospects |
| title_short | Dietary peptides in aging: Evidence and prospects |
| title_sort | dietary peptides in aging evidence and prospects |
| url | http://www.sciencedirect.com/science/article/pii/S2213453019302150 |
| work_keys_str_mv | AT khushwantsbhullar dietarypeptidesinagingevidenceandprospects AT jianpingwu dietarypeptidesinagingevidenceandprospects |