Expression of Toll-Like Receptors 2 and 4 and Related Cytokines in Patients with Hepatic Cystic and Alveolar Echinococcosis
Several studies have demonstrated the important role of Toll-like receptors in various parasitic infections. This study aims to explore expression of Toll-like receptors (TLRs) and related cytokines in patients with human cystic echinococcosis (CE) and alveolar echinococcosis (AE). 78 subjects inclu...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/632760 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832548619288313856 |
|---|---|
| author | Tuerhongjiang Tuxun Hai-Zhang Ma Shadike Apaer Heng Zhang Amina Aierken Yu-Peng Li Ren-Yong Lin Jin-Ming Zhao Jin-Hui Zhang Hao Wen |
| author_facet | Tuerhongjiang Tuxun Hai-Zhang Ma Shadike Apaer Heng Zhang Amina Aierken Yu-Peng Li Ren-Yong Lin Jin-Ming Zhao Jin-Hui Zhang Hao Wen |
| author_sort | Tuerhongjiang Tuxun |
| collection | DOAJ |
| description | Several studies have demonstrated the important role of Toll-like receptors in various parasitic infections. This study aims to explore expression of Toll-like receptors (TLRs) and related cytokines in patients with human cystic echinococcosis (CE) and alveolar echinococcosis (AE). 78 subjects including AE group (N=28), CE group (N=22), and healthy controls (HC, N=28) were enrolled in this study. The mRNA expression levels of TLR2 and TLR4 in blood and hepatic tissue and plasma levels related cytokines were detected by using ELISA. Median levels of TLR2 mRNA in AE and CE groups were significantly elevated as compared with that in healthy control group. Median levels of TLR4 expression were increased in AE and CE. Plasma concentration levels of IL-5, IL-6, and IL-10 were slightly increased in AE and CE groups compared with those in HC group with no statistical differences (p>0.05). The IL-23 concentration levels were significantly higher in AE and CE groups than that in HC subjects with statistical significance. The increased expression of TLR2 and IL-23 might play a potential role in modulating tissue infiltrative growth of the parasite and its persistence in the human host. |
| format | Article |
| id | doaj-art-8be95af4c071417282116519d4fe7353 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-8be95af4c071417282116519d4fe73532025-02-03T06:13:39ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/632760632760Expression of Toll-Like Receptors 2 and 4 and Related Cytokines in Patients with Hepatic Cystic and Alveolar EchinococcosisTuerhongjiang Tuxun0Hai-Zhang Ma1Shadike Apaer2Heng Zhang3Amina Aierken4Yu-Peng Li5Ren-Yong Lin6Jin-Ming Zhao7Jin-Hui Zhang8Hao Wen9State Key Laboratory Incubation Base of Xinjiang Major Diseases Research and Xinjiang Key Laboratory of Echinococcosis, First Affiliated Hospital of Xinjiang Medical University, Ürümqi 830054, ChinaState Key Laboratory Incubation Base of Xinjiang Major Diseases Research and Xinjiang Key Laboratory of Echinococcosis, First Affiliated Hospital of Xinjiang Medical University, Ürümqi 830054, ChinaState Key Laboratory Incubation Base of Xinjiang Major Diseases Research and Xinjiang Key Laboratory of Echinococcosis, First Affiliated Hospital of Xinjiang Medical University, Ürümqi 830054, ChinaState Key Laboratory Incubation Base of Xinjiang Major Diseases Research and Xinjiang Key Laboratory of Echinococcosis, First Affiliated Hospital of Xinjiang Medical University, Ürümqi 830054, ChinaDepartment of Ultrasonography, First Affiliated Hospital of Xinjiang Medical University, Ürümqi 830054, ChinaDepartment of Liver and Laparoscopic Surgery, Digestive and Vascular Centre, First Affiliated Hospital of Xinjiang Medical University, Ürümqi 830054, ChinaState Key Laboratory Incubation Base of Xinjiang Major Diseases Research and Xinjiang Key Laboratory of Echinococcosis, First Affiliated Hospital of Xinjiang Medical University, Ürümqi 830054, ChinaState Key Laboratory Incubation Base of Xinjiang Major Diseases Research and Xinjiang Key Laboratory of Echinococcosis, First Affiliated Hospital of Xinjiang Medical University, Ürümqi 830054, ChinaState Key Laboratory Incubation Base of Xinjiang Major Diseases Research and Xinjiang Key Laboratory of Echinococcosis, First Affiliated Hospital of Xinjiang Medical University, Ürümqi 830054, ChinaState Key Laboratory Incubation Base of Xinjiang Major Diseases Research and Xinjiang Key Laboratory of Echinococcosis, First Affiliated Hospital of Xinjiang Medical University, Ürümqi 830054, ChinaSeveral studies have demonstrated the important role of Toll-like receptors in various parasitic infections. This study aims to explore expression of Toll-like receptors (TLRs) and related cytokines in patients with human cystic echinococcosis (CE) and alveolar echinococcosis (AE). 78 subjects including AE group (N=28), CE group (N=22), and healthy controls (HC, N=28) were enrolled in this study. The mRNA expression levels of TLR2 and TLR4 in blood and hepatic tissue and plasma levels related cytokines were detected by using ELISA. Median levels of TLR2 mRNA in AE and CE groups were significantly elevated as compared with that in healthy control group. Median levels of TLR4 expression were increased in AE and CE. Plasma concentration levels of IL-5, IL-6, and IL-10 were slightly increased in AE and CE groups compared with those in HC group with no statistical differences (p>0.05). The IL-23 concentration levels were significantly higher in AE and CE groups than that in HC subjects with statistical significance. The increased expression of TLR2 and IL-23 might play a potential role in modulating tissue infiltrative growth of the parasite and its persistence in the human host.http://dx.doi.org/10.1155/2015/632760 |
| spellingShingle | Tuerhongjiang Tuxun Hai-Zhang Ma Shadike Apaer Heng Zhang Amina Aierken Yu-Peng Li Ren-Yong Lin Jin-Ming Zhao Jin-Hui Zhang Hao Wen Expression of Toll-Like Receptors 2 and 4 and Related Cytokines in Patients with Hepatic Cystic and Alveolar Echinococcosis Mediators of Inflammation |
| title | Expression of Toll-Like Receptors 2 and 4 and Related Cytokines in Patients with Hepatic Cystic and Alveolar Echinococcosis |
| title_full | Expression of Toll-Like Receptors 2 and 4 and Related Cytokines in Patients with Hepatic Cystic and Alveolar Echinococcosis |
| title_fullStr | Expression of Toll-Like Receptors 2 and 4 and Related Cytokines in Patients with Hepatic Cystic and Alveolar Echinococcosis |
| title_full_unstemmed | Expression of Toll-Like Receptors 2 and 4 and Related Cytokines in Patients with Hepatic Cystic and Alveolar Echinococcosis |
| title_short | Expression of Toll-Like Receptors 2 and 4 and Related Cytokines in Patients with Hepatic Cystic and Alveolar Echinococcosis |
| title_sort | expression of toll like receptors 2 and 4 and related cytokines in patients with hepatic cystic and alveolar echinococcosis |
| url | http://dx.doi.org/10.1155/2015/632760 |
| work_keys_str_mv | AT tuerhongjiangtuxun expressionoftolllikereceptors2and4andrelatedcytokinesinpatientswithhepaticcysticandalveolarechinococcosis AT haizhangma expressionoftolllikereceptors2and4andrelatedcytokinesinpatientswithhepaticcysticandalveolarechinococcosis AT shadikeapaer expressionoftolllikereceptors2and4andrelatedcytokinesinpatientswithhepaticcysticandalveolarechinococcosis AT hengzhang expressionoftolllikereceptors2and4andrelatedcytokinesinpatientswithhepaticcysticandalveolarechinococcosis AT aminaaierken expressionoftolllikereceptors2and4andrelatedcytokinesinpatientswithhepaticcysticandalveolarechinococcosis AT yupengli expressionoftolllikereceptors2and4andrelatedcytokinesinpatientswithhepaticcysticandalveolarechinococcosis AT renyonglin expressionoftolllikereceptors2and4andrelatedcytokinesinpatientswithhepaticcysticandalveolarechinococcosis AT jinmingzhao expressionoftolllikereceptors2and4andrelatedcytokinesinpatientswithhepaticcysticandalveolarechinococcosis AT jinhuizhang expressionoftolllikereceptors2and4andrelatedcytokinesinpatientswithhepaticcysticandalveolarechinococcosis AT haowen expressionoftolllikereceptors2and4andrelatedcytokinesinpatientswithhepaticcysticandalveolarechinococcosis |