Effect of bicarbonate buffer on artificial membrane permeation of drugs

Effect of bicarbonate buffer on artificial membrane permeation of drugs

Background and purpose: The pH value of the small intestine is physiologically maintained by bicarbonate buffer (BCB). However, the effect of BCB on the membrane permeation of drugs has not been investigated. The purpose of this study was to investigate the effect of BCB on the passive membrane per...

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Bibliographic Details
Main Authors:	Shiori Ishida, Sam Lee, Balint Sinko, Karl Box, Kiyohiko Sugano
Format:	Article
Language:	English
Published:	International Association of Physical Chemists (IAPC) 2025-01-01
Series:	ADMET and DMPK
Subjects:	phosphate buffer floating lid lipophilic weakly acidic and basic drugs
Online Access:	https://pub.iapchem.org/ojs/index.php/admet/article/view/2603
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