Overview of Recent Advances in Canine Parvovirus Research: Current Status and Future Perspectives
Canine parvovirus (CPV-2) was first identified in the late 1970s and has since become one of the most significant infectious agents affecting dogs. CPV-2 causes severe diseases such as hemorrhagic gastroenteritis and myocarditis, posing a major threat to canine health, particularly with a high morta...
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2024-12-01
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| author | Hongzhuan Zhou Kaidi Cui Xia Su Huanhuan Zhang Bing Xiao Songping Li Bing Yang |
| author_facet | Hongzhuan Zhou Kaidi Cui Xia Su Huanhuan Zhang Bing Xiao Songping Li Bing Yang |
| author_sort | Hongzhuan Zhou |
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| description | Canine parvovirus (CPV-2) was first identified in the late 1970s and has since become one of the most significant infectious agents affecting dogs. CPV-2 causes severe diseases such as hemorrhagic gastroenteritis and myocarditis, posing a major threat to canine health, particularly with a high mortality rate in puppies. It is globally recognized as a highly contagious and lethal pathogen. CPV is prone to rapid mutation, leading to the emergence of new variants. Despite widespread vaccination efforts, CPV remains one of the primary causes of acute gastroenteritis and death in young and juvenile dogs. Furthermore, the detection of CPV in swine populations has introduced additional challenges to its control. This review summarizes the current epidemiological status of CPV, highlighting recent advancements in diagnostic techniques and vaccine development. Additionally, it discusses the latest research on the pathogenesis of the virus and the development of antiviral agent research and proposes prevention and control suggestions for CPV under the One Health concept. In particular, there is a need to enhance surveillance of viral dynamics, accelerate the development of novel vaccines, and deepen the exploration of the underlying pathogenic mechanisms. This review aims to provide a scientific foundation for effective control of CPV and to guide future research directions. |
| format | Article |
| id | doaj-art-8bca1e1b3adf4e20929131c3c287503d |
| institution | Kabale University |
| issn | 2076-2607 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj-art-8bca1e1b3adf4e20929131c3c287503d2025-01-24T13:42:25ZengMDPI AGMicroorganisms2076-26072024-12-011314710.3390/microorganisms13010047Overview of Recent Advances in Canine Parvovirus Research: Current Status and Future PerspectivesHongzhuan Zhou0Kaidi Cui1Xia Su2Huanhuan Zhang3Bing Xiao4Songping Li5Bing Yang6Beijing Key Laboratory for Prevention and Control of Infectious Diseases in Livestock and Poultry, Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, ChinaBeijing Key Laboratory for Prevention and Control of Infectious Diseases in Livestock and Poultry, Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, ChinaBeijing Key Laboratory for Prevention and Control of Infectious Diseases in Livestock and Poultry, Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, ChinaBeijing Key Laboratory for Prevention and Control of Infectious Diseases in Livestock and Poultry, Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, ChinaBeijing Key Laboratory for Prevention and Control of Infectious Diseases in Livestock and Poultry, Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, ChinaBeijing Key Laboratory for Prevention and Control of Infectious Diseases in Livestock and Poultry, Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, ChinaBeijing Key Laboratory for Prevention and Control of Infectious Diseases in Livestock and Poultry, Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, ChinaCanine parvovirus (CPV-2) was first identified in the late 1970s and has since become one of the most significant infectious agents affecting dogs. CPV-2 causes severe diseases such as hemorrhagic gastroenteritis and myocarditis, posing a major threat to canine health, particularly with a high mortality rate in puppies. It is globally recognized as a highly contagious and lethal pathogen. CPV is prone to rapid mutation, leading to the emergence of new variants. Despite widespread vaccination efforts, CPV remains one of the primary causes of acute gastroenteritis and death in young and juvenile dogs. Furthermore, the detection of CPV in swine populations has introduced additional challenges to its control. This review summarizes the current epidemiological status of CPV, highlighting recent advancements in diagnostic techniques and vaccine development. Additionally, it discusses the latest research on the pathogenesis of the virus and the development of antiviral agent research and proposes prevention and control suggestions for CPV under the One Health concept. In particular, there is a need to enhance surveillance of viral dynamics, accelerate the development of novel vaccines, and deepen the exploration of the underlying pathogenic mechanisms. This review aims to provide a scientific foundation for effective control of CPV and to guide future research directions.https://www.mdpi.com/2076-2607/13/1/47canine parvovirusresearch advancespathogenesisantiviral drugs |
| spellingShingle | Hongzhuan Zhou Kaidi Cui Xia Su Huanhuan Zhang Bing Xiao Songping Li Bing Yang Overview of Recent Advances in Canine Parvovirus Research: Current Status and Future Perspectives Microorganisms canine parvovirus research advances pathogenesis antiviral drugs |
| title | Overview of Recent Advances in Canine Parvovirus Research: Current Status and Future Perspectives |
| title_full | Overview of Recent Advances in Canine Parvovirus Research: Current Status and Future Perspectives |
| title_fullStr | Overview of Recent Advances in Canine Parvovirus Research: Current Status and Future Perspectives |
| title_full_unstemmed | Overview of Recent Advances in Canine Parvovirus Research: Current Status and Future Perspectives |
| title_short | Overview of Recent Advances in Canine Parvovirus Research: Current Status and Future Perspectives |
| title_sort | overview of recent advances in canine parvovirus research current status and future perspectives |
| topic | canine parvovirus research advances pathogenesis antiviral drugs |
| url | https://www.mdpi.com/2076-2607/13/1/47 |
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