TRIM28 is an essential regulator of three-dimensional chromatin state underpinning CD8+ T cell activation

TRIM28 is an essential regulator of three-dimensional chromatin state underpinning CD8+ T cell activation

Abstract T cell activation is accompanied by extensive changes in epigenome. However, the high-ordered chromatin organization underpinning CD8+ T cell activation is not fully known. Here, we show extensive changes in the three-dimensional genome during CD8+ T cell activation, associated with changes...

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Main Authors: Kun Wei, Ruifeng Li, Xiaohong Zhao, Bowen Xie, Tian Xie, Qinli Sun, Yongzhen Chen, Peng Wei, Wei Xu, Xinyi Guo, Zixuan Zhao, Han Feng, Ling Ni, Chen Dong
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56029-z
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https://doi.org/10.1038/s41467-025-56029-z

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