The Interplay of Renin-Angiotensin System and Toll-Like Receptor 4 in the Inflammation of Diabetic Nephropathy
Diabetic nephropathy (DN) is one of the most serious chronic kidney diseases and the major cause of end-stage renal failure worldwide. The underlying mechanisms of DN are complex and required to be further investigated. Both innate immunity and renin-angiotensin system (RAS) play critical roles in t...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2020/6193407 |
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| author | Qi Feng Dongwei Liu Yanfang Lu Zhangsuo Liu |
| author_facet | Qi Feng Dongwei Liu Yanfang Lu Zhangsuo Liu |
| author_sort | Qi Feng |
| collection | DOAJ |
| description | Diabetic nephropathy (DN) is one of the most serious chronic kidney diseases and the major cause of end-stage renal failure worldwide. The underlying mechanisms of DN are complex and required to be further investigated. Both innate immunity and renin-angiotensin system (RAS) play critical roles in the pathogenesis of DN. Except for traditional functions, abnormally regulated RAS has been proved to be involved in the inflammatory process of DN. Toll-like receptor 4 (TLR4) is the most deeply studied pattern recognition receptor in the innate immune system, and its activation has been reported to mediate the development of DN. In this review, we aim at discussing how dysregulated RAS affects TLR4 activation in the kidney that contributes to the exploration of the pathogenesis of DN. Understanding the interplay of RAS and TLR4 in inducing the progression of DN may provide new insights to develop effective treatments. |
| format | Article |
| id | doaj-art-8bb5afc8259440ddbf1a8647db3ec65d |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-8bb5afc8259440ddbf1a8647db3ec65d2025-02-03T01:25:49ZengWileyJournal of Immunology Research2314-88612314-71562020-01-01202010.1155/2020/61934076193407The Interplay of Renin-Angiotensin System and Toll-Like Receptor 4 in the Inflammation of Diabetic NephropathyQi Feng0Dongwei Liu1Yanfang Lu2Zhangsuo Liu3Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, ChinaDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, ChinaDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, ChinaDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, ChinaDiabetic nephropathy (DN) is one of the most serious chronic kidney diseases and the major cause of end-stage renal failure worldwide. The underlying mechanisms of DN are complex and required to be further investigated. Both innate immunity and renin-angiotensin system (RAS) play critical roles in the pathogenesis of DN. Except for traditional functions, abnormally regulated RAS has been proved to be involved in the inflammatory process of DN. Toll-like receptor 4 (TLR4) is the most deeply studied pattern recognition receptor in the innate immune system, and its activation has been reported to mediate the development of DN. In this review, we aim at discussing how dysregulated RAS affects TLR4 activation in the kidney that contributes to the exploration of the pathogenesis of DN. Understanding the interplay of RAS and TLR4 in inducing the progression of DN may provide new insights to develop effective treatments.http://dx.doi.org/10.1155/2020/6193407 |
| spellingShingle | Qi Feng Dongwei Liu Yanfang Lu Zhangsuo Liu The Interplay of Renin-Angiotensin System and Toll-Like Receptor 4 in the Inflammation of Diabetic Nephropathy Journal of Immunology Research |
| title | The Interplay of Renin-Angiotensin System and Toll-Like Receptor 4 in the Inflammation of Diabetic Nephropathy |
| title_full | The Interplay of Renin-Angiotensin System and Toll-Like Receptor 4 in the Inflammation of Diabetic Nephropathy |
| title_fullStr | The Interplay of Renin-Angiotensin System and Toll-Like Receptor 4 in the Inflammation of Diabetic Nephropathy |
| title_full_unstemmed | The Interplay of Renin-Angiotensin System and Toll-Like Receptor 4 in the Inflammation of Diabetic Nephropathy |
| title_short | The Interplay of Renin-Angiotensin System and Toll-Like Receptor 4 in the Inflammation of Diabetic Nephropathy |
| title_sort | interplay of renin angiotensin system and toll like receptor 4 in the inflammation of diabetic nephropathy |
| url | http://dx.doi.org/10.1155/2020/6193407 |
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