Successful Treatment of Acromegaly and Associated Hypogonadism with First-Line Clomiphene Therapy
Clomiphene citrate (CC) has been reported as an effective add-on therapy to somatostatin analogs and dopamine agonists in patients with acromegaly accompanied by hypogonadism; its use as a single agent to treat acromegaly and associated hypogonadism following incomplete surgery has not been previous...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2018/7925019 |
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| author | Juan D. Palacios Ricardo J. Komotar Atil Y. Kargi |
| author_facet | Juan D. Palacios Ricardo J. Komotar Atil Y. Kargi |
| author_sort | Juan D. Palacios |
| collection | DOAJ |
| description | Clomiphene citrate (CC) has been reported as an effective add-on therapy to somatostatin analogs and dopamine agonists in patients with acromegaly accompanied by hypogonadism; its use as a single agent to treat acromegaly and associated hypogonadism following incomplete surgery has not been previously reported. We report the first case in which clomiphene was utilized as a single agent for the dual management of acromegaly and hypogonadism, not controlled by pituitary surgery alone. The treatment was well tolerated and proved to be effective after a process of treatment withdrawal and reintroduction. We propose that clomiphene may be considered as a cost-effective oral treatment option in select cases of hypogonadal acromegaly. |
| format | Article |
| id | doaj-art-8bad60a3404e4639b87a7d0cde059294 |
| institution | Kabale University |
| issn | 2090-6501 2090-651X |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-8bad60a3404e4639b87a7d0cde0592942025-02-03T06:01:20ZengWileyCase Reports in Endocrinology2090-65012090-651X2018-01-01201810.1155/2018/79250197925019Successful Treatment of Acromegaly and Associated Hypogonadism with First-Line Clomiphene TherapyJuan D. Palacios0Ricardo J. Komotar1Atil Y. Kargi2Diabetes & Endocrinology Institute at Renaissance, Edinburg, TX 78539, USADivision of Neurosurgery, University of Miami Miller School of Medicine, Miami, FL 33136, USADivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USAClomiphene citrate (CC) has been reported as an effective add-on therapy to somatostatin analogs and dopamine agonists in patients with acromegaly accompanied by hypogonadism; its use as a single agent to treat acromegaly and associated hypogonadism following incomplete surgery has not been previously reported. We report the first case in which clomiphene was utilized as a single agent for the dual management of acromegaly and hypogonadism, not controlled by pituitary surgery alone. The treatment was well tolerated and proved to be effective after a process of treatment withdrawal and reintroduction. We propose that clomiphene may be considered as a cost-effective oral treatment option in select cases of hypogonadal acromegaly.http://dx.doi.org/10.1155/2018/7925019 |
| spellingShingle | Juan D. Palacios Ricardo J. Komotar Atil Y. Kargi Successful Treatment of Acromegaly and Associated Hypogonadism with First-Line Clomiphene Therapy Case Reports in Endocrinology |
| title | Successful Treatment of Acromegaly and Associated Hypogonadism with First-Line Clomiphene Therapy |
| title_full | Successful Treatment of Acromegaly and Associated Hypogonadism with First-Line Clomiphene Therapy |
| title_fullStr | Successful Treatment of Acromegaly and Associated Hypogonadism with First-Line Clomiphene Therapy |
| title_full_unstemmed | Successful Treatment of Acromegaly and Associated Hypogonadism with First-Line Clomiphene Therapy |
| title_short | Successful Treatment of Acromegaly and Associated Hypogonadism with First-Line Clomiphene Therapy |
| title_sort | successful treatment of acromegaly and associated hypogonadism with first line clomiphene therapy |
| url | http://dx.doi.org/10.1155/2018/7925019 |
| work_keys_str_mv | AT juandpalacios successfultreatmentofacromegalyandassociatedhypogonadismwithfirstlineclomiphenetherapy AT ricardojkomotar successfultreatmentofacromegalyandassociatedhypogonadismwithfirstlineclomiphenetherapy AT atilykargi successfultreatmentofacromegalyandassociatedhypogonadismwithfirstlineclomiphenetherapy |