Tumor-infiltrating mast cells confer resistance to immunotherapy in pancreatic cancer

Tumor-infiltrating mast cells confer resistance to immunotherapy in pancreatic cancer

Summary: Pancreatic ductal adenocarcinoma (PDAC) exhibits an immunosuppressive tumor microenvironment (TME) contributing to its therapeutic resistance. Following our previous studies, we report that mast cells infiltrating the PDAC TME foster this immunosuppression and desmoplasia. Mast cell infiltr...

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Bibliographic Details
Main Authors:	Ying Ma, Xiangqin Zhao, Jingyan Feng, Suimin Qiu, Baoan Ji, Lu Huang, Patrick Hwu, Craig D. Logsdon, Huamin Wang
Format:	Article
Language:	English
Published:	Elsevier 2024-11-01
Series:	iScience
Subjects:	Molecular biology Neuroscience Immunology Cancer
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004224023101
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