Alpha-Lipoic Acid Promotes Intestinal Epithelial Injury Repair by Regulating MAPK Signaling Pathways
Intestinal epithelial cells are an essential barrier in human gastrointestinal tract, and healing of epithelial wound is a key process in many intestinal diseases. α-Lipoic acid (ALA) was shown to have antioxidative and anti-inflammatory effects, which could be helpful in intestinal epithelial injur...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2022/1894379 |
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| author | Yu Yang Yong Xiao Yue Jiang Jiajun Luo Jingwen Yuan Junfeng Yan Qiang Tong |
| author_facet | Yu Yang Yong Xiao Yue Jiang Jiajun Luo Jingwen Yuan Junfeng Yan Qiang Tong |
| author_sort | Yu Yang |
| collection | DOAJ |
| description | Intestinal epithelial cells are an essential barrier in human gastrointestinal tract, and healing of epithelial wound is a key process in many intestinal diseases. α-Lipoic acid (ALA) was shown to have antioxidative and anti-inflammatory effects, which could be helpful in intestinal epithelial injury repair. The effects of ALA in human colonic epithelial cells NCM460 and human colorectal adenocarcinoma cells Caco-2 were studied. ALA significantly promoted NCM460 and Caco-2 migration, increased mucosal tight junction factors ZO-1 and OCLN expression, and ALA accelerated cell injury repair of both cells in wound healing assay. Western blot analysis indicated that ALA inhibited a variety of mitogen-activated protein kinase (MAPK) signaling pathways in the epithelial cells. In conclusion, ALA was beneficial to repair of intestinal epithelial injury by regulating MAPK signaling pathways. |
| format | Article |
| id | doaj-art-8b9d04d65b794b92b79779ce45e0070a |
| institution | Kabale University |
| issn | 1466-1861 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-8b9d04d65b794b92b79779ce45e0070a2025-02-03T01:07:22ZengWileyMediators of Inflammation1466-18612022-01-01202210.1155/2022/1894379Alpha-Lipoic Acid Promotes Intestinal Epithelial Injury Repair by Regulating MAPK Signaling PathwaysYu Yang0Yong Xiao1Yue Jiang2Jiajun Luo3Jingwen Yuan4Junfeng Yan5Qiang Tong6Department of Gastrointestinal Surgery I SectionDepartment of GastroenterologyDepartment of Gastrointestinal Surgery I SectionDepartment of Gastrointestinal Surgery I SectionDepartment of Gastrointestinal Surgery I SectionDepartment of Gastrointestinal Surgery I SectionDepartment of Gastrointestinal Surgery I SectionIntestinal epithelial cells are an essential barrier in human gastrointestinal tract, and healing of epithelial wound is a key process in many intestinal diseases. α-Lipoic acid (ALA) was shown to have antioxidative and anti-inflammatory effects, which could be helpful in intestinal epithelial injury repair. The effects of ALA in human colonic epithelial cells NCM460 and human colorectal adenocarcinoma cells Caco-2 were studied. ALA significantly promoted NCM460 and Caco-2 migration, increased mucosal tight junction factors ZO-1 and OCLN expression, and ALA accelerated cell injury repair of both cells in wound healing assay. Western blot analysis indicated that ALA inhibited a variety of mitogen-activated protein kinase (MAPK) signaling pathways in the epithelial cells. In conclusion, ALA was beneficial to repair of intestinal epithelial injury by regulating MAPK signaling pathways.http://dx.doi.org/10.1155/2022/1894379 |
| spellingShingle | Yu Yang Yong Xiao Yue Jiang Jiajun Luo Jingwen Yuan Junfeng Yan Qiang Tong Alpha-Lipoic Acid Promotes Intestinal Epithelial Injury Repair by Regulating MAPK Signaling Pathways Mediators of Inflammation |
| title | Alpha-Lipoic Acid Promotes Intestinal Epithelial Injury Repair by Regulating MAPK Signaling Pathways |
| title_full | Alpha-Lipoic Acid Promotes Intestinal Epithelial Injury Repair by Regulating MAPK Signaling Pathways |
| title_fullStr | Alpha-Lipoic Acid Promotes Intestinal Epithelial Injury Repair by Regulating MAPK Signaling Pathways |
| title_full_unstemmed | Alpha-Lipoic Acid Promotes Intestinal Epithelial Injury Repair by Regulating MAPK Signaling Pathways |
| title_short | Alpha-Lipoic Acid Promotes Intestinal Epithelial Injury Repair by Regulating MAPK Signaling Pathways |
| title_sort | alpha lipoic acid promotes intestinal epithelial injury repair by regulating mapk signaling pathways |
| url | http://dx.doi.org/10.1155/2022/1894379 |
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