Association of phosphorylation status of ERK and genetic MAPK alterations in pediatric tumors

Association of phosphorylation status of ERK and genetic MAPK alterations in pediatric tumors

Abstract The mitogen-activated protein kinase (MAPK) pathway is one of the most frequently altered pathways in pediatric cancer. Activating genomic MAPK-alterations and phosphorylation of the MAPK downstream target ERK (pERK) were analyzed in the PTT2.0 registry to identify potential targets for MAP...

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Bibliographic Details
Main Authors: Florian Selt, Romain Sigaud, Andrey Korshunov, David Capper, David Reuss, Andreas von Deimling, Kristian W. Pajtler, Cornelis M. van Tilburg, Martina Nesper-Brock, David T. W. Jones, Stefan M. Pfister, Felix Sahm, Olaf Witt, Till Milde, Jonas Ecker
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Relapsed pediatric tumors
Molecular diagnostics
MAPK alterations
pERK
Targeted therapy
pERK H-score
Online Access:https://doi.org/10.1038/s41598-025-98514-x
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