Impact of body mass index as a continuous variable on short‐ and long‐term outcomes in patients undergoing laparoscopic surgery for colon cancer

Impact of body mass index as a continuous variable on short‐ and long‐term outcomes in patients undergoing laparoscopic surgery for colon cancer

Abstract Background The impact of obesity on colon cancer remains unclear. Very few studies of colon cancer surgery have analyzed body mass index (BMI) as a continuous variable, with no such reports from Japan. This study examined the association between BMI as a continuous variable and short‐ and l...

Full description

Saved in:
Bibliographic Details
Main Authors: Takayuki Aiba, Tomonori Akagi, Hidefumi Shiroshita, Kentaro Nakajima, Tetsuji Ohyama, Tatsuya Kinjo, Akiyoshi Kanazawa, Nobuaki Suzuki, Takuya Tokunaga, Manabu Yamamoto, Nobuki Ichikawa, Shungo Endo, Yutaka Kojima, Takatoshi Nakamura, Shuji Saito, Yoshinori Kagawa, Shinobu Ohnuma, Seiichiro Yamamoto, Takeshi Naitoh, Masafumi Inomata
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Annals of Gastroenterological Surgery
Subjects:
body mass index
colon cancer
continuous variable
laparoscopic surgery
obesity paradox
Online Access:https://doi.org/10.1002/ags3.12916
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Background The impact of obesity on colon cancer remains unclear. Very few studies of colon cancer surgery have analyzed body mass index (BMI) as a continuous variable, with no such reports from Japan. This study examined the association between BMI as a continuous variable and short‐ and long‐term outcomes of laparoscopic surgery for obese colon cancer patients. Methods Obese (BMI ≥25 kg/m2) patients who underwent laparoscopic radical surgery for Stage II/III colon cancer at 46 participating centers from 2009 to 2013 were included. Associations between short‐ and long‐term outcomes and BMI as a continuous variable were analyzed by univariate and multivariate regression models. Results Among patients meeting the study criteria, 1036 were examined. BMI as a continuous variable correlated with log‐transformed operative time (regression coefficient: 0.02, 95% confidence interval [CI]: 0.012–0.028, p < 0.05) and blood loss (odds ratio: 1.089, 95% CI: 1.032–1.149, p < 0.05). There was no association between BMI continuous variables and 3‐year relapse‐free survival (RFS) and overall survival. However, 3‐year RFS was possibly better in patients with BMI ≥28.5 kg/m2 versus those with BMI <28.5 kg/m2 (hazard ratio: 0.682, 95% CI: 0.462–1.008, p = 0.055). Conclusions This study showed that BMI as a continuous variable correlated with operative time and blood loss. RFS was possibly better in the severely obese patients (BMI ≥28.5 kg/m2), suggesting that the prognosis for highly obese colon cancer patients appears to follow the obesity paradox.
ISSN:2475-0328

Similar Items