Pathologic complete response following low-dose radiation for advanced oral cavity cancer in a patient with human immunodeficiency virus
Abstract Background Advanced squamous cell carcinoma (SCCa) of the oral cavity is often not amenable to curative-intent therapy due to tumor location, tumor size, or comorbidities. Case presentation A 51-year-old male patient with human immunodeficiency virus and on highly active antiretroviral ther...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2022-10-01
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| Series: | Journal of Otolaryngology - Head and Neck Surgery |
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| Online Access: | https://doi.org/10.1186/s40463-022-00586-6 |
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| author | Amy B. Leming Andrea L. Johnston Greg A. Krempl Evan J. Fowle Daniel J. Morton Christina E. Henson |
| author_facet | Amy B. Leming Andrea L. Johnston Greg A. Krempl Evan J. Fowle Daniel J. Morton Christina E. Henson |
| author_sort | Amy B. Leming |
| collection | DOAJ |
| description | Abstract Background Advanced squamous cell carcinoma (SCCa) of the oral cavity is often not amenable to curative-intent therapy due to tumor location, tumor size, or comorbidities. Case presentation A 51-year-old male patient with human immunodeficiency virus and on highly active antiretroviral therapy (HAART) presented with a cT4aN2c SCCa of the tongue. He received a preoperative single course of Quad-Shot radiation therapy to 14 Gy in 4 fractions followed by surgical resection. Patient had no residual carcinoma on surgical pathology and no evidence of disease on subsequent clinical and radiological exams. Conclusions To our knowledge, this is the first case of pathologic complete response for a patient on HAART following a single cycle of the Quad-Shot regimen for advanced oral cavity SCCa. Protease inhibitors in HAART can induce spontaneous tumor regression via inhibition of proteasome function and activation of apoptosis, and thus act as a cancer therapeutic. Graphical Abstract |
| format | Article |
| id | doaj-art-8b8784601ed24727a165daf579f69863 |
| institution | Kabale University |
| issn | 1916-0216 |
| language | English |
| publishDate | 2022-10-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Otolaryngology - Head and Neck Surgery |
| spelling | doaj-art-8b8784601ed24727a165daf579f698632025-02-03T10:54:11ZengSAGE PublishingJournal of Otolaryngology - Head and Neck Surgery1916-02162022-10-015111710.1186/s40463-022-00586-6Pathologic complete response following low-dose radiation for advanced oral cavity cancer in a patient with human immunodeficiency virusAmy B. Leming0Andrea L. Johnston1Greg A. Krempl2Evan J. Fowle3Daniel J. Morton4Christina E. Henson5College of Medicine, University of Oklahoma Health Sciences CenterDepartment of Radiation Oncology, University of Oklahoma Health Sciences CenterDepartment of Otorhinolaryngology, University of Oklahoma Health Sciences CenterDepartment of Pathology, University of Oklahoma Health Sciences CenterStephenson Cancer Center, University of Oklahoma Health Sciences CenterDepartment of Radiation Oncology, University of Oklahoma Health Sciences CenterAbstract Background Advanced squamous cell carcinoma (SCCa) of the oral cavity is often not amenable to curative-intent therapy due to tumor location, tumor size, or comorbidities. Case presentation A 51-year-old male patient with human immunodeficiency virus and on highly active antiretroviral therapy (HAART) presented with a cT4aN2c SCCa of the tongue. He received a preoperative single course of Quad-Shot radiation therapy to 14 Gy in 4 fractions followed by surgical resection. Patient had no residual carcinoma on surgical pathology and no evidence of disease on subsequent clinical and radiological exams. Conclusions To our knowledge, this is the first case of pathologic complete response for a patient on HAART following a single cycle of the Quad-Shot regimen for advanced oral cavity SCCa. Protease inhibitors in HAART can induce spontaneous tumor regression via inhibition of proteasome function and activation of apoptosis, and thus act as a cancer therapeutic. Graphical Abstracthttps://doi.org/10.1186/s40463-022-00586-6Oral cavity cancerRadiation therapyHIVHAART |
| spellingShingle | Amy B. Leming Andrea L. Johnston Greg A. Krempl Evan J. Fowle Daniel J. Morton Christina E. Henson Pathologic complete response following low-dose radiation for advanced oral cavity cancer in a patient with human immunodeficiency virus Journal of Otolaryngology - Head and Neck Surgery Oral cavity cancer Radiation therapy HIV HAART |
| title | Pathologic complete response following low-dose radiation for advanced oral cavity cancer in a patient with human immunodeficiency virus |
| title_full | Pathologic complete response following low-dose radiation for advanced oral cavity cancer in a patient with human immunodeficiency virus |
| title_fullStr | Pathologic complete response following low-dose radiation for advanced oral cavity cancer in a patient with human immunodeficiency virus |
| title_full_unstemmed | Pathologic complete response following low-dose radiation for advanced oral cavity cancer in a patient with human immunodeficiency virus |
| title_short | Pathologic complete response following low-dose radiation for advanced oral cavity cancer in a patient with human immunodeficiency virus |
| title_sort | pathologic complete response following low dose radiation for advanced oral cavity cancer in a patient with human immunodeficiency virus |
| topic | Oral cavity cancer Radiation therapy HIV HAART |
| url | https://doi.org/10.1186/s40463-022-00586-6 |
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