A Four-Year Study of Antibiotic Resistance, Prevalence and Biofilm-Forming Ability of Uropathogens Isolated from Community- and Hospital-Acquired Urinary Tract Infections in Southern Italy
The aim of this study was to investigate the differences between nosocomial and community microorganisms isolated from patients with UTI by determining their bacterial profile, antibiotic resistance and ability to produce biofilms. A retrospective study, based on bacterial isolates from consecutive...
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2025-01-01
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| author | Marilena Trinchera Angelina Midiri Giuseppe Mancuso Maria Antonietta Lagrotteria Carmelo Antonio De Ani Carmelo Biondo |
| author_facet | Marilena Trinchera Angelina Midiri Giuseppe Mancuso Maria Antonietta Lagrotteria Carmelo Antonio De Ani Carmelo Biondo |
| author_sort | Marilena Trinchera |
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| description | The aim of this study was to investigate the differences between nosocomial and community microorganisms isolated from patients with UTI by determining their bacterial profile, antibiotic resistance and ability to produce biofilms. A retrospective study, based on bacterial isolates from consecutive urine samples collected between January 2019 and December 2023, was conducted at a university hospital. The main pathogens isolated from both community and hospital samples were the same, but their frequency of isolation differed. Compared with community-associated cases, hospital-associated infections have more isolates of <i>Acinetobacter baumanii complex</i>. In contrast, <i>Proteus mirabilis</i> isolates were more prevalent in community than in hospital infections. In both hospital and community isolates, gram-positive bacteria showed a lower overall antimicrobial resistance (22%) compared to gram-negative bacteria (30%). The data demonstrated that individual strains exhibited disparate degrees of capacity for biofilm formation. Additionally, the data indicate an inverse correlation between biofilm production and antibiotic resistance. Isolates from community patients exhibited lower capacities for biofilm production in comparison to the capacities demonstrated by microorganisms isolated from nosocomial patients (29% and 35%, respectively). Area-specific surveillance studies can provide valuable information on UTI pathogens and antimicrobial resistance patterns, which can be useful in guiding empirical treatment. |
| format | Article |
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| institution | Kabale University |
| issn | 2076-0817 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| series | Pathogens |
| spelling | doaj-art-8b7ca3f5541f421a95ee0f2cfc42719d2025-01-24T13:44:45ZengMDPI AGPathogens2076-08172025-01-011415910.3390/pathogens14010059A Four-Year Study of Antibiotic Resistance, Prevalence and Biofilm-Forming Ability of Uropathogens Isolated from Community- and Hospital-Acquired Urinary Tract Infections in Southern ItalyMarilena Trinchera0Angelina Midiri1Giuseppe Mancuso2Maria Antonietta Lagrotteria3Carmelo Antonio De Ani4Carmelo Biondo5Department of Human Pathology, University of Messina, 98125 Messina, ItalyDepartment of Human Pathology, University of Messina, 98125 Messina, ItalyDepartment of Human Pathology, University of Messina, 98125 Messina, ItalyDepartment of Human Pathology, University of Messina, 98125 Messina, ItalyDepartment of Human Pathology, University of Messina, 98125 Messina, ItalyDepartment of Human Pathology, University of Messina, 98125 Messina, ItalyThe aim of this study was to investigate the differences between nosocomial and community microorganisms isolated from patients with UTI by determining their bacterial profile, antibiotic resistance and ability to produce biofilms. A retrospective study, based on bacterial isolates from consecutive urine samples collected between January 2019 and December 2023, was conducted at a university hospital. The main pathogens isolated from both community and hospital samples were the same, but their frequency of isolation differed. Compared with community-associated cases, hospital-associated infections have more isolates of <i>Acinetobacter baumanii complex</i>. In contrast, <i>Proteus mirabilis</i> isolates were more prevalent in community than in hospital infections. In both hospital and community isolates, gram-positive bacteria showed a lower overall antimicrobial resistance (22%) compared to gram-negative bacteria (30%). The data demonstrated that individual strains exhibited disparate degrees of capacity for biofilm formation. Additionally, the data indicate an inverse correlation between biofilm production and antibiotic resistance. Isolates from community patients exhibited lower capacities for biofilm production in comparison to the capacities demonstrated by microorganisms isolated from nosocomial patients (29% and 35%, respectively). Area-specific surveillance studies can provide valuable information on UTI pathogens and antimicrobial resistance patterns, which can be useful in guiding empirical treatment.https://www.mdpi.com/2076-0817/14/1/59hospital-acquired urinary tract infections (HA-UTI)community-acquired urinary tract infections (CA-UTI)biofilmMDR |
| spellingShingle | Marilena Trinchera Angelina Midiri Giuseppe Mancuso Maria Antonietta Lagrotteria Carmelo Antonio De Ani Carmelo Biondo A Four-Year Study of Antibiotic Resistance, Prevalence and Biofilm-Forming Ability of Uropathogens Isolated from Community- and Hospital-Acquired Urinary Tract Infections in Southern Italy Pathogens hospital-acquired urinary tract infections (HA-UTI) community-acquired urinary tract infections (CA-UTI) biofilm MDR |
| title | A Four-Year Study of Antibiotic Resistance, Prevalence and Biofilm-Forming Ability of Uropathogens Isolated from Community- and Hospital-Acquired Urinary Tract Infections in Southern Italy |
| title_full | A Four-Year Study of Antibiotic Resistance, Prevalence and Biofilm-Forming Ability of Uropathogens Isolated from Community- and Hospital-Acquired Urinary Tract Infections in Southern Italy |
| title_fullStr | A Four-Year Study of Antibiotic Resistance, Prevalence and Biofilm-Forming Ability of Uropathogens Isolated from Community- and Hospital-Acquired Urinary Tract Infections in Southern Italy |
| title_full_unstemmed | A Four-Year Study of Antibiotic Resistance, Prevalence and Biofilm-Forming Ability of Uropathogens Isolated from Community- and Hospital-Acquired Urinary Tract Infections in Southern Italy |
| title_short | A Four-Year Study of Antibiotic Resistance, Prevalence and Biofilm-Forming Ability of Uropathogens Isolated from Community- and Hospital-Acquired Urinary Tract Infections in Southern Italy |
| title_sort | four year study of antibiotic resistance prevalence and biofilm forming ability of uropathogens isolated from community and hospital acquired urinary tract infections in southern italy |
| topic | hospital-acquired urinary tract infections (HA-UTI) community-acquired urinary tract infections (CA-UTI) biofilm MDR |
| url | https://www.mdpi.com/2076-0817/14/1/59 |
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