Association between Leptin, Metabolic Factors and Liver Histology in Patients with Chronic Hepatitis C
BACKGROUND: Steatosis is common in hepatitis C virus (HCV)-infected patients and likely accelerates fibrosis progression. Leptin, the peptide product of the obesity gene (ob), has been implicated in hepatic fibrogenesis; circulating levels of leptin correlate with body fat mass. The objective of the...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2007-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2007/876076 |
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| _version_ | 1832554507556356096 |
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| author | Robert P Myers Djamila Messous Thierry Poynard Francoise Imbert-Bismut |
| author_facet | Robert P Myers Djamila Messous Thierry Poynard Francoise Imbert-Bismut |
| author_sort | Robert P Myers |
| collection | DOAJ |
| description | BACKGROUND: Steatosis is common in hepatitis C virus (HCV)-infected patients and likely accelerates fibrosis progression. Leptin, the peptide product of the obesity gene (ob), has been implicated in hepatic fibrogenesis; circulating levels of leptin correlate with body fat mass. The objective of the present study was to determine the clinical and histological correlates of serum leptin in HCV-infected patients, and to determine its utility in predicting liver histological lesions. |
| format | Article |
| id | doaj-art-8b61c8ea63474cb3be0c78b157e646a8 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2007-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-8b61c8ea63474cb3be0c78b157e646a82025-02-03T05:51:25ZengWileyCanadian Journal of Gastroenterology0835-79002007-01-0121528929410.1155/2007/876076Association between Leptin, Metabolic Factors and Liver Histology in Patients with Chronic Hepatitis CRobert P Myers0Djamila Messous1Thierry Poynard2Francoise Imbert-Bismut3Liver Unit, Division of Gastroenterology, Department of Medicine, University of Calgary, Calgary, Alberta, CanadaService d’Hépato-Gastro-Entérologie, Hôpital La Pitié-Salpêtrière, Paris, FranceService d’Hépato-Gastro-Entérologie, Hôpital La Pitié-Salpêtrière, Paris, FranceService de Biochimie, Hôpital La Pitié-Salpêtrière, Paris, FranceBACKGROUND: Steatosis is common in hepatitis C virus (HCV)-infected patients and likely accelerates fibrosis progression. Leptin, the peptide product of the obesity gene (ob), has been implicated in hepatic fibrogenesis; circulating levels of leptin correlate with body fat mass. The objective of the present study was to determine the clinical and histological correlates of serum leptin in HCV-infected patients, and to determine its utility in predicting liver histological lesions.http://dx.doi.org/10.1155/2007/876076 |
| spellingShingle | Robert P Myers Djamila Messous Thierry Poynard Francoise Imbert-Bismut Association between Leptin, Metabolic Factors and Liver Histology in Patients with Chronic Hepatitis C Canadian Journal of Gastroenterology |
| title | Association between Leptin, Metabolic Factors and Liver Histology in Patients with Chronic Hepatitis C |
| title_full | Association between Leptin, Metabolic Factors and Liver Histology in Patients with Chronic Hepatitis C |
| title_fullStr | Association between Leptin, Metabolic Factors and Liver Histology in Patients with Chronic Hepatitis C |
| title_full_unstemmed | Association between Leptin, Metabolic Factors and Liver Histology in Patients with Chronic Hepatitis C |
| title_short | Association between Leptin, Metabolic Factors and Liver Histology in Patients with Chronic Hepatitis C |
| title_sort | association between leptin metabolic factors and liver histology in patients with chronic hepatitis c |
| url | http://dx.doi.org/10.1155/2007/876076 |
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