Usefulness of perampanel as initial monotherapy in children with non-lesional focal epilepsy
This study aimed to compare carbamazepine (CBZ) and perampanel (PER) in terms of the efficacy against clinical seizures and electroencephalographic abnormalities such as interictal epileptiform discharges (IEDs) and safety as initial monotherapy in children with non-lesional focal epilepsies. This r...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-03-01
|
| Series: | Epilepsy & Behavior Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589986425000036 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832087390437507072 |
|---|---|
| author | Hideaki Kanemura Yoshihiro Miyasato Yutaro Tomi Fumikazu Sano |
| author_facet | Hideaki Kanemura Yoshihiro Miyasato Yutaro Tomi Fumikazu Sano |
| author_sort | Hideaki Kanemura |
| collection | DOAJ |
| description | This study aimed to compare carbamazepine (CBZ) and perampanel (PER) in terms of the efficacy against clinical seizures and electroencephalographic abnormalities such as interictal epileptiform discharges (IEDs) and safety as initial monotherapy in children with non-lesional focal epilepsies. This retrospective review included participants recruited from among epilepsy outpatients treated at the authors’ hospital between January 01, 2000, and December 31, 2019 in the CBZ group and between January 01, 2020, and December 31, 2022 in the PER group. The inclusion criterion in both groups was ≥12 months of follow-up. Responders were identified as participants demonstrating complete disappearance (100 % reduction in seizures or IEDs) or response (>50 % reduction in seizure frequency or IEDs). Safety primary outcome was defined as appearance rate of AEs. The study group comprised 247 participants treated with CBZ and 46 participants treated with PER. Total efficacy rate for clinical seizures was significantly higher with PER than with CBZ (p = 0.0148). Moreover, the rate of complete disappearance was significantly higher with PER than with CBZ (p = 0.0133). Total efficacy rate for IED was again significantly higher with PER than with CBZ (p < 0.0001). The appearance of adverse events was significantly lower with PER than with CBZ (p = 0.023). PER may be useful as initial monotherapy in children with non-lesional focal epilepsies. |
| format | Article |
| id | doaj-art-8b604915cdae4ced84307fea5aa932a6 |
| institution | Kabale University |
| issn | 2589-9864 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Epilepsy & Behavior Reports |
| spelling | doaj-art-8b604915cdae4ced84307fea5aa932a62025-02-06T05:12:40ZengElsevierEpilepsy & Behavior Reports2589-98642025-03-0129100743Usefulness of perampanel as initial monotherapy in children with non-lesional focal epilepsyHideaki Kanemura0Yoshihiro Miyasato1Yutaro Tomi2Fumikazu Sano3Department of Pediatrics, Toho University Medical Center Sakura Hospital, Sakura, Chiba 285-8741, Japan; Department of Pediatrics, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi 409-3898, Japan; Corresponding author at: Department of Pediatrics, Toho University Medical Center Sakura Hospital, Sakura, Chiba 285-8741, Japan.Department of Pediatrics, Toho University Medical Center Sakura Hospital, Sakura, Chiba 285-8741, JapanDepartment of Pediatrics, Toho University Medical Center Sakura Hospital, Sakura, Chiba 285-8741, JapanDepartment of Pediatrics, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi 409-3898, JapanThis study aimed to compare carbamazepine (CBZ) and perampanel (PER) in terms of the efficacy against clinical seizures and electroencephalographic abnormalities such as interictal epileptiform discharges (IEDs) and safety as initial monotherapy in children with non-lesional focal epilepsies. This retrospective review included participants recruited from among epilepsy outpatients treated at the authors’ hospital between January 01, 2000, and December 31, 2019 in the CBZ group and between January 01, 2020, and December 31, 2022 in the PER group. The inclusion criterion in both groups was ≥12 months of follow-up. Responders were identified as participants demonstrating complete disappearance (100 % reduction in seizures or IEDs) or response (>50 % reduction in seizure frequency or IEDs). Safety primary outcome was defined as appearance rate of AEs. The study group comprised 247 participants treated with CBZ and 46 participants treated with PER. Total efficacy rate for clinical seizures was significantly higher with PER than with CBZ (p = 0.0148). Moreover, the rate of complete disappearance was significantly higher with PER than with CBZ (p = 0.0133). Total efficacy rate for IED was again significantly higher with PER than with CBZ (p < 0.0001). The appearance of adverse events was significantly lower with PER than with CBZ (p = 0.023). PER may be useful as initial monotherapy in children with non-lesional focal epilepsies.http://www.sciencedirect.com/science/article/pii/S2589986425000036PER, perampanelfocal epilepsyAntiseizure medication, ASMIED, interictal epileptiform dischargeChildinitial monotherapy |
| spellingShingle | Hideaki Kanemura Yoshihiro Miyasato Yutaro Tomi Fumikazu Sano Usefulness of perampanel as initial monotherapy in children with non-lesional focal epilepsy Epilepsy & Behavior Reports PER, perampanel focal epilepsy Antiseizure medication, ASM IED, interictal epileptiform discharge Child initial monotherapy |
| title | Usefulness of perampanel as initial monotherapy in children with non-lesional focal epilepsy |
| title_full | Usefulness of perampanel as initial monotherapy in children with non-lesional focal epilepsy |
| title_fullStr | Usefulness of perampanel as initial monotherapy in children with non-lesional focal epilepsy |
| title_full_unstemmed | Usefulness of perampanel as initial monotherapy in children with non-lesional focal epilepsy |
| title_short | Usefulness of perampanel as initial monotherapy in children with non-lesional focal epilepsy |
| title_sort | usefulness of perampanel as initial monotherapy in children with non lesional focal epilepsy |
| topic | PER, perampanel focal epilepsy Antiseizure medication, ASM IED, interictal epileptiform discharge Child initial monotherapy |
| url | http://www.sciencedirect.com/science/article/pii/S2589986425000036 |
| work_keys_str_mv | AT hideakikanemura usefulnessofperampanelasinitialmonotherapyinchildrenwithnonlesionalfocalepilepsy AT yoshihiromiyasato usefulnessofperampanelasinitialmonotherapyinchildrenwithnonlesionalfocalepilepsy AT yutarotomi usefulnessofperampanelasinitialmonotherapyinchildrenwithnonlesionalfocalepilepsy AT fumikazusano usefulnessofperampanelasinitialmonotherapyinchildrenwithnonlesionalfocalepilepsy |