Safety and efficacy of the amino acid-crosslinked hyaluronic acid in the treatment of temple hollowing
Background: Loss of volume in the temples is an early sign of aging and often gives the impression of a gaunt and emaciated appearance. Objective: The authors conduct a clinical study to investigate the safety and effectiveness of the amino acid crosslinked hyaluronic acid (ACHA) for the treatment o...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Asian Journal of Surgery |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S101595842402414X |
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| author | Yanping Guo Puzhen Li Wuhan Wei Qiang Li Caiqi Shen Xiaoying Zhuo Yujie Luo Jie Liu Peisheng Jin Xueyang Li |
| author_facet | Yanping Guo Puzhen Li Wuhan Wei Qiang Li Caiqi Shen Xiaoying Zhuo Yujie Luo Jie Liu Peisheng Jin Xueyang Li |
| author_sort | Yanping Guo |
| collection | DOAJ |
| description | Background: Loss of volume in the temples is an early sign of aging and often gives the impression of a gaunt and emaciated appearance. Objective: The authors conduct a clinical study to investigate the safety and effectiveness of the amino acid crosslinked hyaluronic acid (ACHA) for the treatment of temple hollowing. Methods: 75 subjects with Temple Hollowing Scale (THS) from 2 to 4 were enrolled and assigned according to the ratio of 2 (ACHA group, n = 50): 1 (no treatment control group, n = 25). All subjects were assessed at the 12-month follow-up visit using the THS, Global Aesthetic Improvement Scale (GAIS), ultrasound, and three-dimensional scanning. Subjects were instructed to report any adverse events (AEs) within 14 days after the ACHA treatment. Results: An average volume of 4.72 ± 1.13 ml was injected into the temples. We received 18 treatment-related AEs reported by 10 subjects. Compared with the control group, THS, GAIS, and soft tissue thickness were significantly improved in the ACHA group at 1 month, 6, and 12 months after injection. Three-dimensional scanning showed that ACHA could maintain a certain volume in the temple 12 months after ACHA injection. Conclusions: ACHA is an effective and safe hyaluronic acid for patients with minimal to severe temple hollowing. |
| format | Article |
| id | doaj-art-8b4f546c88b2469495ca2876f31cd637 |
| institution | Kabale University |
| issn | 1015-9584 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Surgery |
| spelling | doaj-art-8b4f546c88b2469495ca2876f31cd6372025-01-30T05:13:41ZengElsevierAsian Journal of Surgery1015-95842025-02-0148210341040Safety and efficacy of the amino acid-crosslinked hyaluronic acid in the treatment of temple hollowingYanping Guo0Puzhen Li1Wuhan Wei2Qiang Li3Caiqi Shen4Xiaoying Zhuo5Yujie Luo6Jie Liu7Peisheng Jin8Xueyang Li9Center of Plastic and Aesthetic Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, PR ChinaThe First Clinical Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, PR ChinaPlastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR ChinaCenter of Plastic and Aesthetic Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, PR ChinaCenter of Plastic and Aesthetic Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, PR ChinaDepartment of Medical Ultrasound, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, PR ChinaDepartment of Medical Ultrasound, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, PR ChinaDepartment of Medical Ultrasound, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, PR ChinaCenter of Plastic and Aesthetic Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, PR China; Corresponding author.Center of Plastic and Aesthetic Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, PR China; Corresponding author.Background: Loss of volume in the temples is an early sign of aging and often gives the impression of a gaunt and emaciated appearance. Objective: The authors conduct a clinical study to investigate the safety and effectiveness of the amino acid crosslinked hyaluronic acid (ACHA) for the treatment of temple hollowing. Methods: 75 subjects with Temple Hollowing Scale (THS) from 2 to 4 were enrolled and assigned according to the ratio of 2 (ACHA group, n = 50): 1 (no treatment control group, n = 25). All subjects were assessed at the 12-month follow-up visit using the THS, Global Aesthetic Improvement Scale (GAIS), ultrasound, and three-dimensional scanning. Subjects were instructed to report any adverse events (AEs) within 14 days after the ACHA treatment. Results: An average volume of 4.72 ± 1.13 ml was injected into the temples. We received 18 treatment-related AEs reported by 10 subjects. Compared with the control group, THS, GAIS, and soft tissue thickness were significantly improved in the ACHA group at 1 month, 6, and 12 months after injection. Three-dimensional scanning showed that ACHA could maintain a certain volume in the temple 12 months after ACHA injection. Conclusions: ACHA is an effective and safe hyaluronic acid for patients with minimal to severe temple hollowing.http://www.sciencedirect.com/science/article/pii/S101595842402414XHyaluronic acidSoft-tissue fillerTemple rejuvenationVolumization |
| spellingShingle | Yanping Guo Puzhen Li Wuhan Wei Qiang Li Caiqi Shen Xiaoying Zhuo Yujie Luo Jie Liu Peisheng Jin Xueyang Li Safety and efficacy of the amino acid-crosslinked hyaluronic acid in the treatment of temple hollowing Asian Journal of Surgery Hyaluronic acid Soft-tissue filler Temple rejuvenation Volumization |
| title | Safety and efficacy of the amino acid-crosslinked hyaluronic acid in the treatment of temple hollowing |
| title_full | Safety and efficacy of the amino acid-crosslinked hyaluronic acid in the treatment of temple hollowing |
| title_fullStr | Safety and efficacy of the amino acid-crosslinked hyaluronic acid in the treatment of temple hollowing |
| title_full_unstemmed | Safety and efficacy of the amino acid-crosslinked hyaluronic acid in the treatment of temple hollowing |
| title_short | Safety and efficacy of the amino acid-crosslinked hyaluronic acid in the treatment of temple hollowing |
| title_sort | safety and efficacy of the amino acid crosslinked hyaluronic acid in the treatment of temple hollowing |
| topic | Hyaluronic acid Soft-tissue filler Temple rejuvenation Volumization |
| url | http://www.sciencedirect.com/science/article/pii/S101595842402414X |
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