Pleural metastases from differentiated thyroid cancer: clinical features and long-term outcomes
Objective: Pleural metastasis (PM) is rare in patients with differentiated thyroid cancer (DTC). Radioiodine (131I) therapy has been the main treatment for postoperative metastasis and recurrence of DTC. However, clinical data on PM from DTC are limited. This study investigated the clinicopathologic...
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Bioscientifica
2025-01-01
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| Series: | European Thyroid Journal |
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| Online Access: | https://etj.bioscientifica.com/view/journals/etj/14/1/ETJ-24-0147.xml |
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| author | Mengyue Liu Juan Tang Nan Sun Chuang Xi Chentian Shen Song Hongjun Quanyong Luo Xianzhao Deng Zhongling Qiu |
| author_facet | Mengyue Liu Juan Tang Nan Sun Chuang Xi Chentian Shen Song Hongjun Quanyong Luo Xianzhao Deng Zhongling Qiu |
| author_sort | Mengyue Liu |
| collection | DOAJ |
| description | Objective: Pleural metastasis (PM) is rare in patients with differentiated thyroid cancer (DTC). Radioiodine (131I) therapy has been the main treatment for postoperative metastasis and recurrence of DTC. However, clinical data on PM from DTC are limited. This study investigated the clinicopathological characteristics of patients with PM from DTC that were treated surgically and with 131I therapy and evaluated their long-term prognosis and prognostic factors. Methods: A review of the Shanghai Sixth People’s Hospital medical records from 2010 to 2023 identified PM in 27 of 14,473 patients with DTC. Overall survival (OS) was assessed by the Kaplan–Meier method. Results: The prevalence of PM in DTC was 1.87‰ (27/14,473). The median age at the time of initial diagnosis of PM was 59 years (range: 34–79). At the end of follow-up, eight patients (29.63%) had disease progression (PD), four (14.81%) had a partial response, and the remainder had stable disease; no patient achieved complete response. Twelve patients (44.44%) died, and 15 (55.56%) survived. Thirteen patients (48.15%) did not show 131I avidity, and 16 (59.26%) had radioiodine-refractory DTC (RR-DTC). Twenty patients (74.07%) had malignant pleural effusion (MPE), which was large in 11 cases (40.74%) and moderate in two. More-than-moderate MPE (P = 0.031), lack of 131I avidity (P = 0.041) and RR-DTC (P = 0.030) were significantly associated with worse 5-year OS in patients with PM of DTC. Conclusions: PM is rare in DTC. Lack of 131I avidity, RR-DTC and more-than-moderate MPE are associated with poor OS in patients with DTC and PM. |
| format | Article |
| id | doaj-art-8b4ecec4b8d94eecaa3956c687953090 |
| institution | Kabale University |
| issn | 2235-0802 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | European Thyroid Journal |
| spelling | doaj-art-8b4ecec4b8d94eecaa3956c6879530902025-02-05T10:18:56ZengBioscientificaEuropean Thyroid Journal2235-08022025-01-0114110.1530/ETJ-24-01471Pleural metastases from differentiated thyroid cancer: clinical features and long-term outcomesMengyue Liu0Juan Tang1Nan Sun2Chuang Xi3Chentian Shen4Song Hongjun5Quanyong Luo6Xianzhao Deng7Zhongling Qiu8Department of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Pathology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of General Surgery, Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaObjective: Pleural metastasis (PM) is rare in patients with differentiated thyroid cancer (DTC). Radioiodine (131I) therapy has been the main treatment for postoperative metastasis and recurrence of DTC. However, clinical data on PM from DTC are limited. This study investigated the clinicopathological characteristics of patients with PM from DTC that were treated surgically and with 131I therapy and evaluated their long-term prognosis and prognostic factors. Methods: A review of the Shanghai Sixth People’s Hospital medical records from 2010 to 2023 identified PM in 27 of 14,473 patients with DTC. Overall survival (OS) was assessed by the Kaplan–Meier method. Results: The prevalence of PM in DTC was 1.87‰ (27/14,473). The median age at the time of initial diagnosis of PM was 59 years (range: 34–79). At the end of follow-up, eight patients (29.63%) had disease progression (PD), four (14.81%) had a partial response, and the remainder had stable disease; no patient achieved complete response. Twelve patients (44.44%) died, and 15 (55.56%) survived. Thirteen patients (48.15%) did not show 131I avidity, and 16 (59.26%) had radioiodine-refractory DTC (RR-DTC). Twenty patients (74.07%) had malignant pleural effusion (MPE), which was large in 11 cases (40.74%) and moderate in two. More-than-moderate MPE (P = 0.031), lack of 131I avidity (P = 0.041) and RR-DTC (P = 0.030) were significantly associated with worse 5-year OS in patients with PM of DTC. Conclusions: PM is rare in DTC. Lack of 131I avidity, RR-DTC and more-than-moderate MPE are associated with poor OS in patients with DTC and PM.https://etj.bioscientifica.com/view/journals/etj/14/1/ETJ-24-0147.xmlpleural metastasesmalignant pleural effusionradioiodine aviditydifferentiated thyroid cancer |
| spellingShingle | Mengyue Liu Juan Tang Nan Sun Chuang Xi Chentian Shen Song Hongjun Quanyong Luo Xianzhao Deng Zhongling Qiu Pleural metastases from differentiated thyroid cancer: clinical features and long-term outcomes European Thyroid Journal pleural metastases malignant pleural effusion radioiodine avidity differentiated thyroid cancer |
| title | Pleural metastases from differentiated thyroid cancer: clinical features and long-term outcomes |
| title_full | Pleural metastases from differentiated thyroid cancer: clinical features and long-term outcomes |
| title_fullStr | Pleural metastases from differentiated thyroid cancer: clinical features and long-term outcomes |
| title_full_unstemmed | Pleural metastases from differentiated thyroid cancer: clinical features and long-term outcomes |
| title_short | Pleural metastases from differentiated thyroid cancer: clinical features and long-term outcomes |
| title_sort | pleural metastases from differentiated thyroid cancer clinical features and long term outcomes |
| topic | pleural metastases malignant pleural effusion radioiodine avidity differentiated thyroid cancer |
| url | https://etj.bioscientifica.com/view/journals/etj/14/1/ETJ-24-0147.xml |
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