Role of Stat3 in Skin Carcinogenesis: Insights Gained from Relevant Mouse Models
Signal transducer and activator of transcription 3 (Stat3) is a cytoplasmic protein that is activated in response to cytokines and growth factors and acts as a transcription factor. Stat3 plays critical roles in various biological activities including cell proliferation, migration, and survival. Stu...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Skin Cancer |
| Online Access: | http://dx.doi.org/10.1155/2013/684050 |
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| _version_ | 1832548687658614784 |
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| author | Everardo Macias Dharanija Rao John DiGiovanni |
| author_facet | Everardo Macias Dharanija Rao John DiGiovanni |
| author_sort | Everardo Macias |
| collection | DOAJ |
| description | Signal transducer and activator of transcription 3 (Stat3) is a cytoplasmic protein that is activated in response to cytokines and growth factors and acts as a transcription factor. Stat3 plays critical roles in various biological activities including cell proliferation, migration, and survival. Studies using keratinocyte-specific Stat3-deficient mice have revealed that Stat3 plays an important role in skin homeostasis including keratinocyte migration, wound healing, and hair follicle growth. Use of both constitutive and inducible keratinocyte-specific Stat3-deficient mouse models has demonstrated that Stat3 is required for both the initiation and promotion stages of multistage skin carcinogenesis. Further studies using a transgenic mouse model with a gain of function mutant of Stat3 (Stat3C) expressed in the basal layer of the epidermis revealed a novel role for Stat3 in skin tumor progression. Studies using similar Stat3-deficient and gain-of-function mouse models have indicated its similar roles in ultraviolet B (UVB) radiation-mediated skin carcinogenesis. This paper summarizes the use of these various mouse models for studying the role and underlying mechanisms for the function of Stat3 in skin carcinogenesis. Given its significant role throughout the skin carcinogenesis process, Stat3 is an attractive target for skin cancer prevention and treatment. |
| format | Article |
| id | doaj-art-8b463cceeec842a5bee874509e3ce82f |
| institution | Kabale University |
| issn | 2090-2905 2090-2913 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Skin Cancer |
| spelling | doaj-art-8b463cceeec842a5bee874509e3ce82f2025-02-03T06:13:22ZengWileyJournal of Skin Cancer2090-29052090-29132013-01-01201310.1155/2013/684050684050Role of Stat3 in Skin Carcinogenesis: Insights Gained from Relevant Mouse ModelsEverardo Macias0Dharanija Rao1John DiGiovanni2Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX 78723, USADivision of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX 78723, USADivision of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX 78723, USASignal transducer and activator of transcription 3 (Stat3) is a cytoplasmic protein that is activated in response to cytokines and growth factors and acts as a transcription factor. Stat3 plays critical roles in various biological activities including cell proliferation, migration, and survival. Studies using keratinocyte-specific Stat3-deficient mice have revealed that Stat3 plays an important role in skin homeostasis including keratinocyte migration, wound healing, and hair follicle growth. Use of both constitutive and inducible keratinocyte-specific Stat3-deficient mouse models has demonstrated that Stat3 is required for both the initiation and promotion stages of multistage skin carcinogenesis. Further studies using a transgenic mouse model with a gain of function mutant of Stat3 (Stat3C) expressed in the basal layer of the epidermis revealed a novel role for Stat3 in skin tumor progression. Studies using similar Stat3-deficient and gain-of-function mouse models have indicated its similar roles in ultraviolet B (UVB) radiation-mediated skin carcinogenesis. This paper summarizes the use of these various mouse models for studying the role and underlying mechanisms for the function of Stat3 in skin carcinogenesis. Given its significant role throughout the skin carcinogenesis process, Stat3 is an attractive target for skin cancer prevention and treatment.http://dx.doi.org/10.1155/2013/684050 |
| spellingShingle | Everardo Macias Dharanija Rao John DiGiovanni Role of Stat3 in Skin Carcinogenesis: Insights Gained from Relevant Mouse Models Journal of Skin Cancer |
| title | Role of Stat3 in Skin Carcinogenesis: Insights Gained from Relevant Mouse Models |
| title_full | Role of Stat3 in Skin Carcinogenesis: Insights Gained from Relevant Mouse Models |
| title_fullStr | Role of Stat3 in Skin Carcinogenesis: Insights Gained from Relevant Mouse Models |
| title_full_unstemmed | Role of Stat3 in Skin Carcinogenesis: Insights Gained from Relevant Mouse Models |
| title_short | Role of Stat3 in Skin Carcinogenesis: Insights Gained from Relevant Mouse Models |
| title_sort | role of stat3 in skin carcinogenesis insights gained from relevant mouse models |
| url | http://dx.doi.org/10.1155/2013/684050 |
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