Reorganization of the Action Observation Network and Sensory-Motor System in Children with Unilateral Cerebral Palsy: An fMRI Study
Little is known about the action observation network (AON) in children with unilateral cerebral palsy (UCP). Using fMRI, we aimed to explore AON and sensory-motor network (SMN) in UCP children and compare them to typically developed (TD) children and analyse the relationship between AON (re-)organiz...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2018/6950547 |
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| author | Giuseppina Sgandurra Laura Biagi Leonardo Fogassi Elisa Sicola Adriano Ferrari Andrea Guzzetta Michela Tosetti Giovanni Cioni |
| author_facet | Giuseppina Sgandurra Laura Biagi Leonardo Fogassi Elisa Sicola Adriano Ferrari Andrea Guzzetta Michela Tosetti Giovanni Cioni |
| author_sort | Giuseppina Sgandurra |
| collection | DOAJ |
| description | Little is known about the action observation network (AON) in children with unilateral cerebral palsy (UCP). Using fMRI, we aimed to explore AON and sensory-motor network (SMN) in UCP children and compare them to typically developed (TD) children and analyse the relationship between AON (re-)organization and several neurophysiological and clinical measures. Twelve UCP children were assessed with clinical scales and transcranial magnetic stimulation (TMS). For the fMRI study, they underwent a paradigm based on observation of complex and simple object-manipulation tasks executed by dominant and nondominant hand. Moreover, UCP and TD children carried out a further fMRI session to explore SMN in both an active motor and passive sensory task. AON in the UCP group showed higher lateralization, negatively related to performances on clinical scales, and had greater activation of unaffected hemisphere as compared to the bilateral representation in the TD group. In addition, a good congruence was found between bilateral or contralateral activation of AON and activation of SMN and TMS data. These findings indicate that our paradigm might be useful in exploring AON and the response to therapy in UCP subjects. |
| format | Article |
| id | doaj-art-8b2fe5a08ba542f497d2f6cbb052cce8 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-8b2fe5a08ba542f497d2f6cbb052cce82025-02-03T01:10:32ZengWileyNeural Plasticity2090-59041687-54432018-01-01201810.1155/2018/69505476950547Reorganization of the Action Observation Network and Sensory-Motor System in Children with Unilateral Cerebral Palsy: An fMRI StudyGiuseppina Sgandurra0Laura Biagi1Leonardo Fogassi2Elisa Sicola3Adriano Ferrari4Andrea Guzzetta5Michela Tosetti6Giovanni Cioni7Department of Developmental Neuroscience, IRCCS Fondazione Stella Maris, Calambrone, Pisa, ItalyLaboratory of Medical Physics and Biotechnologies for Magnetic Resonance, IRCCS Fondazione Stella Maris, Calambrone, Pisa, ItalyDepartment of Neuroscience, University of Parma and Istituto Italiano di Tecnologia (RTM), Parma, ItalyDepartment of Developmental Neuroscience, IRCCS Fondazione Stella Maris, Calambrone, Pisa, ItalyIRCCS S. Maria Nuova Hospital, Reggio Emilia, ItalyDepartment of Developmental Neuroscience, IRCCS Fondazione Stella Maris, Calambrone, Pisa, ItalyLaboratory of Medical Physics and Biotechnologies for Magnetic Resonance, IRCCS Fondazione Stella Maris, Calambrone, Pisa, ItalyDepartment of Developmental Neuroscience, IRCCS Fondazione Stella Maris, Calambrone, Pisa, ItalyLittle is known about the action observation network (AON) in children with unilateral cerebral palsy (UCP). Using fMRI, we aimed to explore AON and sensory-motor network (SMN) in UCP children and compare them to typically developed (TD) children and analyse the relationship between AON (re-)organization and several neurophysiological and clinical measures. Twelve UCP children were assessed with clinical scales and transcranial magnetic stimulation (TMS). For the fMRI study, they underwent a paradigm based on observation of complex and simple object-manipulation tasks executed by dominant and nondominant hand. Moreover, UCP and TD children carried out a further fMRI session to explore SMN in both an active motor and passive sensory task. AON in the UCP group showed higher lateralization, negatively related to performances on clinical scales, and had greater activation of unaffected hemisphere as compared to the bilateral representation in the TD group. In addition, a good congruence was found between bilateral or contralateral activation of AON and activation of SMN and TMS data. These findings indicate that our paradigm might be useful in exploring AON and the response to therapy in UCP subjects.http://dx.doi.org/10.1155/2018/6950547 |
| spellingShingle | Giuseppina Sgandurra Laura Biagi Leonardo Fogassi Elisa Sicola Adriano Ferrari Andrea Guzzetta Michela Tosetti Giovanni Cioni Reorganization of the Action Observation Network and Sensory-Motor System in Children with Unilateral Cerebral Palsy: An fMRI Study Neural Plasticity |
| title | Reorganization of the Action Observation Network and Sensory-Motor System in Children with Unilateral Cerebral Palsy: An fMRI Study |
| title_full | Reorganization of the Action Observation Network and Sensory-Motor System in Children with Unilateral Cerebral Palsy: An fMRI Study |
| title_fullStr | Reorganization of the Action Observation Network and Sensory-Motor System in Children with Unilateral Cerebral Palsy: An fMRI Study |
| title_full_unstemmed | Reorganization of the Action Observation Network and Sensory-Motor System in Children with Unilateral Cerebral Palsy: An fMRI Study |
| title_short | Reorganization of the Action Observation Network and Sensory-Motor System in Children with Unilateral Cerebral Palsy: An fMRI Study |
| title_sort | reorganization of the action observation network and sensory motor system in children with unilateral cerebral palsy an fmri study |
| url | http://dx.doi.org/10.1155/2018/6950547 |
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