Profiles of systemic lupus erythematosus patients with co-existing sickle cell disease: a coincidence or true association?
Introduction Systemic lupus erythematosus (SLE) and sickle cell disease (SCD) are distinct multisystemic diseases that commonly affect blacks. There are few reports of their co-existence in Western literature and a paucity of reports in Sub-Saharan Africa. Their co-existence is associated with diagn...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Termedia Publishing House
2024-12-01
|
| Series: | Rheumatology |
| Subjects: | |
| Online Access: | https://reu.termedia.pl/Profiles-of-systemic-lupus-erythematosus-patients-with-co-existing-sickle-cell-disease,195432,0,2.html |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832584801892171776 |
|---|---|
| author | Hakeem Babatunde Olaosebikan Etseoghena Igebu Adebukola Khairat Orolu Gbenga Joshua Odunlami Ilo Azizat Bamisebi Akin Dada Ebele Uche Olufemi Adelowo |
| author_facet | Hakeem Babatunde Olaosebikan Etseoghena Igebu Adebukola Khairat Orolu Gbenga Joshua Odunlami Ilo Azizat Bamisebi Akin Dada Ebele Uche Olufemi Adelowo |
| author_sort | Hakeem Babatunde Olaosebikan |
| collection | DOAJ |
| description | Introduction
Systemic lupus erythematosus (SLE) and sickle cell disease (SCD) are distinct multisystemic diseases that commonly affect blacks. There are few reports of their co-existence in Western literature and a paucity of reports in Sub-Saharan Africa. Their co-existence is associated with diagnostic delay and treatment dilemmas. The aim is to describe the clinical, laboratory, and treatment profile of Nigerian lupus with sickle cell disease.
Material and methods
A 7-year retrospective descriptive study of lupus patients with sickle cell disease was performed. Medical records of eligible patients were extracted into a proforma, transferred into SPSS, and analyzed with descriptive statistics. Sociodemographic, clinical, laboratory, and treatment data were presented as frequency and percentages.
Results
Twelve SLE-SCD cases (female 11, male 1) were identified. The mean age was 28.5 years and the mean duration of illness prior to diagnosis was 9.5 years. The median follow-up period was 3.1 years and the common presentations were mucocutaneous (66%), renal, (50%) serositis (33%), and neurological (16%) in decreasing order. All had anemia and positive antinuclear antibody, 33% had pancytopenia and 75% had positive anti-dsDNA and anti-Smith. Two are on maintenance hemodialysis, one with interstitial lung disease, and one on long-term anticoagulation due to deep vein thrombosis.
Conclusions
Sickle cell disease and SLE should be considered in SCD with atypical clinical and laboratory features. We hope this report will raise diagnostic suspicion and prompt early diagnosis and treatment to prevent multiorgan damage that may ensue from such an association. |
| format | Article |
| id | doaj-art-8b2fc636290d498c8c135cf283bac374 |
| institution | Kabale University |
| issn | 0034-6233 2084-9834 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Rheumatology |
| spelling | doaj-art-8b2fc636290d498c8c135cf283bac3742025-01-27T11:21:26ZengTermedia Publishing HouseRheumatology0034-62332084-98342024-12-0162643043810.5114/reum/195432195432Profiles of systemic lupus erythematosus patients with co-existing sickle cell disease: a coincidence or true association?Hakeem Babatunde Olaosebikan0https://orcid.org/0000-0003-4004-0093Etseoghena Igebu1Adebukola Khairat Orolu2Gbenga Joshua Odunlami3https://orcid.org/0000-0001-5995-5678Ilo Azizat Bamisebi4Akin Dada5Ebele Uche6Olufemi Adelowo7https://orcid.org/0000-0002-9866-036XDepartment of Medicine, Lagos State University College of Medicine (LASUCOM), Ikeja, NigeriaDepartment of Medicine, Lagos State University Teaching Hospital, Ikeja, NigeriaDepartment of Hematology, Alimosho General Hospital, Ikeja, NigeriaDepartment of Medicine, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, NigeriaDepartment of General Medicine, Reliance Medical Clinics, Abuja, NigeriaDepartment of Medicine, Lagos State University College of Medicine (LASUCOM), Ikeja, NigeriaDepartment of Medicine, Lagos State University College of Medicine (LASUCOM), Ikeja, NigeriaDepartment of Medicine, Lagos State University Teaching Hospital, Ikeja, NigeriaIntroduction Systemic lupus erythematosus (SLE) and sickle cell disease (SCD) are distinct multisystemic diseases that commonly affect blacks. There are few reports of their co-existence in Western literature and a paucity of reports in Sub-Saharan Africa. Their co-existence is associated with diagnostic delay and treatment dilemmas. The aim is to describe the clinical, laboratory, and treatment profile of Nigerian lupus with sickle cell disease. Material and methods A 7-year retrospective descriptive study of lupus patients with sickle cell disease was performed. Medical records of eligible patients were extracted into a proforma, transferred into SPSS, and analyzed with descriptive statistics. Sociodemographic, clinical, laboratory, and treatment data were presented as frequency and percentages. Results Twelve SLE-SCD cases (female 11, male 1) were identified. The mean age was 28.5 years and the mean duration of illness prior to diagnosis was 9.5 years. The median follow-up period was 3.1 years and the common presentations were mucocutaneous (66%), renal, (50%) serositis (33%), and neurological (16%) in decreasing order. All had anemia and positive antinuclear antibody, 33% had pancytopenia and 75% had positive anti-dsDNA and anti-Smith. Two are on maintenance hemodialysis, one with interstitial lung disease, and one on long-term anticoagulation due to deep vein thrombosis. Conclusions Sickle cell disease and SLE should be considered in SCD with atypical clinical and laboratory features. We hope this report will raise diagnostic suspicion and prompt early diagnosis and treatment to prevent multiorgan damage that may ensue from such an association.https://reu.termedia.pl/Profiles-of-systemic-lupus-erythematosus-patients-with-co-existing-sickle-cell-disease,195432,0,2.htmllupussickle cell diseasesprofileclinicallaboratory |
| spellingShingle | Hakeem Babatunde Olaosebikan Etseoghena Igebu Adebukola Khairat Orolu Gbenga Joshua Odunlami Ilo Azizat Bamisebi Akin Dada Ebele Uche Olufemi Adelowo Profiles of systemic lupus erythematosus patients with co-existing sickle cell disease: a coincidence or true association? Rheumatology lupus sickle cell diseases profile clinical laboratory |
| title | Profiles of systemic lupus erythematosus patients with co-existing sickle cell disease: a coincidence or true association? |
| title_full | Profiles of systemic lupus erythematosus patients with co-existing sickle cell disease: a coincidence or true association? |
| title_fullStr | Profiles of systemic lupus erythematosus patients with co-existing sickle cell disease: a coincidence or true association? |
| title_full_unstemmed | Profiles of systemic lupus erythematosus patients with co-existing sickle cell disease: a coincidence or true association? |
| title_short | Profiles of systemic lupus erythematosus patients with co-existing sickle cell disease: a coincidence or true association? |
| title_sort | profiles of systemic lupus erythematosus patients with co existing sickle cell disease a coincidence or true association |
| topic | lupus sickle cell diseases profile clinical laboratory |
| url | https://reu.termedia.pl/Profiles-of-systemic-lupus-erythematosus-patients-with-co-existing-sickle-cell-disease,195432,0,2.html |
| work_keys_str_mv | AT hakeembabatundeolaosebikan profilesofsystemiclupuserythematosuspatientswithcoexistingsicklecelldiseaseacoincidenceortrueassociation AT etseoghenaigebu profilesofsystemiclupuserythematosuspatientswithcoexistingsicklecelldiseaseacoincidenceortrueassociation AT adebukolakhairatorolu profilesofsystemiclupuserythematosuspatientswithcoexistingsicklecelldiseaseacoincidenceortrueassociation AT gbengajoshuaodunlami profilesofsystemiclupuserythematosuspatientswithcoexistingsicklecelldiseaseacoincidenceortrueassociation AT iloazizatbamisebi profilesofsystemiclupuserythematosuspatientswithcoexistingsicklecelldiseaseacoincidenceortrueassociation AT akindada profilesofsystemiclupuserythematosuspatientswithcoexistingsicklecelldiseaseacoincidenceortrueassociation AT ebeleuche profilesofsystemiclupuserythematosuspatientswithcoexistingsicklecelldiseaseacoincidenceortrueassociation AT olufemiadelowo profilesofsystemiclupuserythematosuspatientswithcoexistingsicklecelldiseaseacoincidenceortrueassociation |