Results from the Population-Based Gutenberg Health Study Revealing Four Altered Autoantibodies in Retinal Vein Occlusion Patients
Purpose. Retinal vein occlusion (RVO) is the second most common retinal vascular disease and a major cause of visual impairment. In this study, we aimed to observe whether RVO cases have different antibody profiles as a new potential risk factor and whether a conversion of retinal vein occlusion (RV...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2020/8386160 |
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| author | Katharina Bell Vanessa M. Beutgen Stefan Nickels Katrin Lorenz Yvonne Scheller Hisham Elbaz Tunde Peto Katharina A. Ponto Andreas Schulz Philipp S. Wild Thomas Münzel Karl J. Lackner Irene Schmidtmann Manfred Beutel Norbert Pfeiffer Franz H. Grus Alexander K. Schuster |
| author_facet | Katharina Bell Vanessa M. Beutgen Stefan Nickels Katrin Lorenz Yvonne Scheller Hisham Elbaz Tunde Peto Katharina A. Ponto Andreas Schulz Philipp S. Wild Thomas Münzel Karl J. Lackner Irene Schmidtmann Manfred Beutel Norbert Pfeiffer Franz H. Grus Alexander K. Schuster |
| author_sort | Katharina Bell |
| collection | DOAJ |
| description | Purpose. Retinal vein occlusion (RVO) is the second most common retinal vascular disease and a major cause of visual impairment. In this study, we aimed to observe whether RVO cases have different antibody profiles as a new potential risk factor and whether a conversion of retinal vein occlusion (RVO) to neovascular glaucoma (NVG), one of the major complications, is occurring within a 5-year timeframe. Methods. We performed a nested case-control study (1 : 4) within the Gutenberg Health Study (GHS), a population-based, prospective cohort study in the Rhine-Main Region of Germany including 15,010 participants. RVO subjects (n = 59) were identified by grading of fundus photographs. Optic nerves of RVO subjects and age- and sex-matched controls (n = 229) at baseline and their follow-up examination after 5 years were analyzed for glaucomatous alterations. Of all RVO subjects and controls, serum autoantibody profiles were measured using in-house manufactured antigen-antibody microarrays. Results. Of the 59 RVO patients, 3 patients (5%) showed glaucomatous optic disc alterations at baseline, whereas no new glaucoma case was detected at 5-year follow-up. Four of the autoantibodies measured (against dermcidin, neurotrophin-3, superoxide dismutase 1, and signal recognition particle 14 kDa protein) were significantly increased in the serum of RVO patients p<0.001. Multivariable conditional logistic regression analysis showed that 3 of these 4 antibodies were independent of cardiovascular risk factors. Conclusions. We found several autoantibodies associated with RVO, targeting proteins and structures possibly involved in RVO pathogenesis. |
| format | Article |
| id | doaj-art-8b16410dfbbb40d096a79f3cee1683e2 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-8b16410dfbbb40d096a79f3cee1683e22025-02-03T05:44:11ZengWileyJournal of Ophthalmology2090-004X2090-00582020-01-01202010.1155/2020/83861608386160Results from the Population-Based Gutenberg Health Study Revealing Four Altered Autoantibodies in Retinal Vein Occlusion PatientsKatharina Bell0Vanessa M. Beutgen1Stefan Nickels2Katrin Lorenz3Yvonne Scheller4Hisham Elbaz5Tunde Peto6Katharina A. Ponto7Andreas Schulz8Philipp S. Wild9Thomas Münzel10Karl J. Lackner11Irene Schmidtmann12Manfred Beutel13Norbert Pfeiffer14Franz H. Grus15Alexander K. Schuster16Department of Ophthalmology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, GermanyDepartment of Ophthalmology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, GermanyDepartment of Ophthalmology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, GermanyDepartment of Ophthalmology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, GermanyDepartment of Ophthalmology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, GermanyDepartment of Ophthalmology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, GermanyCentre for Public Health, Queen’s University Belfast, Belfast, UKDepartment of Ophthalmology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, GermanyDepartment of Ophthalmology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, GermanyCenter for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, GermanyCenter for Cardiology I, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, GermanyDepartment for Clinical Chemistry and Laboratory Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, GermanyInstitute of Medical Biostatistics,Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, GermanyDepartment of Psychosomatic Medicine and Psychotherapy, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, GermanyDepartment of Ophthalmology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, GermanyDepartment of Ophthalmology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, GermanyDepartment of Ophthalmology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, GermanyPurpose. Retinal vein occlusion (RVO) is the second most common retinal vascular disease and a major cause of visual impairment. In this study, we aimed to observe whether RVO cases have different antibody profiles as a new potential risk factor and whether a conversion of retinal vein occlusion (RVO) to neovascular glaucoma (NVG), one of the major complications, is occurring within a 5-year timeframe. Methods. We performed a nested case-control study (1 : 4) within the Gutenberg Health Study (GHS), a population-based, prospective cohort study in the Rhine-Main Region of Germany including 15,010 participants. RVO subjects (n = 59) were identified by grading of fundus photographs. Optic nerves of RVO subjects and age- and sex-matched controls (n = 229) at baseline and their follow-up examination after 5 years were analyzed for glaucomatous alterations. Of all RVO subjects and controls, serum autoantibody profiles were measured using in-house manufactured antigen-antibody microarrays. Results. Of the 59 RVO patients, 3 patients (5%) showed glaucomatous optic disc alterations at baseline, whereas no new glaucoma case was detected at 5-year follow-up. Four of the autoantibodies measured (against dermcidin, neurotrophin-3, superoxide dismutase 1, and signal recognition particle 14 kDa protein) were significantly increased in the serum of RVO patients p<0.001. Multivariable conditional logistic regression analysis showed that 3 of these 4 antibodies were independent of cardiovascular risk factors. Conclusions. We found several autoantibodies associated with RVO, targeting proteins and structures possibly involved in RVO pathogenesis.http://dx.doi.org/10.1155/2020/8386160 |
| spellingShingle | Katharina Bell Vanessa M. Beutgen Stefan Nickels Katrin Lorenz Yvonne Scheller Hisham Elbaz Tunde Peto Katharina A. Ponto Andreas Schulz Philipp S. Wild Thomas Münzel Karl J. Lackner Irene Schmidtmann Manfred Beutel Norbert Pfeiffer Franz H. Grus Alexander K. Schuster Results from the Population-Based Gutenberg Health Study Revealing Four Altered Autoantibodies in Retinal Vein Occlusion Patients Journal of Ophthalmology |
| title | Results from the Population-Based Gutenberg Health Study Revealing Four Altered Autoantibodies in Retinal Vein Occlusion Patients |
| title_full | Results from the Population-Based Gutenberg Health Study Revealing Four Altered Autoantibodies in Retinal Vein Occlusion Patients |
| title_fullStr | Results from the Population-Based Gutenberg Health Study Revealing Four Altered Autoantibodies in Retinal Vein Occlusion Patients |
| title_full_unstemmed | Results from the Population-Based Gutenberg Health Study Revealing Four Altered Autoantibodies in Retinal Vein Occlusion Patients |
| title_short | Results from the Population-Based Gutenberg Health Study Revealing Four Altered Autoantibodies in Retinal Vein Occlusion Patients |
| title_sort | results from the population based gutenberg health study revealing four altered autoantibodies in retinal vein occlusion patients |
| url | http://dx.doi.org/10.1155/2020/8386160 |
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