The Relationship between Carotid Intima-Media Thickness and Ocular Circulation in Type-2 Diabetes
Purpose. To compare clinical findings, including ocular blood flow and intima-media thickness (IMT) of the carotid artery, in mild nonproliferative diabetic retinopathy (NPDR) and no diabetic retinopathy (NDR) patients, and to determine risk factors contributing to mild NPDR. Methods. In 129 subject...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2019/3421305 |
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| author | Kohei Ichinohasama Hiroshi Kunikata Azusa Ito Masayuki Yasuda Shojiro Sawada Keiichi Kondo Chihiro Satake Hideki Katagiri Toru Nakazawa |
| author_facet | Kohei Ichinohasama Hiroshi Kunikata Azusa Ito Masayuki Yasuda Shojiro Sawada Keiichi Kondo Chihiro Satake Hideki Katagiri Toru Nakazawa |
| author_sort | Kohei Ichinohasama |
| collection | DOAJ |
| description | Purpose. To compare clinical findings, including ocular blood flow and intima-media thickness (IMT) of the carotid artery, in mild nonproliferative diabetic retinopathy (NPDR) and no diabetic retinopathy (NDR) patients, and to determine risk factors contributing to mild NPDR. Methods. In 129 subjects (129 eyes) with type-2 diabetes patients and mild NPDR or NDR, standard statistical techniques were used to determine associations between clinical findings, including diabetes duration, blood levels of creatinine and hemoglobin A1c (HbA1c), central macular thickness (CMT; measured with optical coherence tomography), mean blur rate (MBR; measured with laser speckle flowgraphy), and ultrasound-measured carotid IMT. Results. Diabetes duration, IMT, and CMT were significantly higher in the mild NPDR patients than the NDR patients (P=0.004, P=0.004, and P=0.003, respectively), while conversely, MBR in the overall optic nerve head (MBR-A) was lower in the mild NPDR patients. Furthermore, a logistic regression analysis showed that diabetes duration (OR, 1.11; P=0.006), diastolic blood pressure (OR, 0.93; P=0.025), heart rate (OR, 1.07; P=0.004), IMT (OR, 8.65; P=0.005), and CMT (OR, 1.03; P=0.007) were independent contributing factors to mild NPDR. Spearman’s rank correlation test also showed that IMT was negatively correlated with MBR-A (P=0.011). Conclusions. Increased IMT showed a close association with ocular ischemia in patients with type-2 diabetes and contributed to the presence of mild NPDR. These findings suggest that IMT may be an early biomarker of mild NPDR. |
| format | Article |
| id | doaj-art-8b1477fd7bf54e748b603bbb75f9ecc5 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-8b1477fd7bf54e748b603bbb75f9ecc52025-02-03T06:01:34ZengWileyJournal of Ophthalmology2090-004X2090-00582019-01-01201910.1155/2019/34213053421305The Relationship between Carotid Intima-Media Thickness and Ocular Circulation in Type-2 DiabetesKohei Ichinohasama0Hiroshi Kunikata1Azusa Ito2Masayuki Yasuda3Shojiro Sawada4Keiichi Kondo5Chihiro Satake6Hideki Katagiri7Toru Nakazawa8Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, JapanDepartment of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, JapanDepartment of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, JapanDepartment of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, JapanDepartment of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, JapanDepartment of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, JapanDepartment of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, JapanDepartment of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, JapanDepartment of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, JapanPurpose. To compare clinical findings, including ocular blood flow and intima-media thickness (IMT) of the carotid artery, in mild nonproliferative diabetic retinopathy (NPDR) and no diabetic retinopathy (NDR) patients, and to determine risk factors contributing to mild NPDR. Methods. In 129 subjects (129 eyes) with type-2 diabetes patients and mild NPDR or NDR, standard statistical techniques were used to determine associations between clinical findings, including diabetes duration, blood levels of creatinine and hemoglobin A1c (HbA1c), central macular thickness (CMT; measured with optical coherence tomography), mean blur rate (MBR; measured with laser speckle flowgraphy), and ultrasound-measured carotid IMT. Results. Diabetes duration, IMT, and CMT were significantly higher in the mild NPDR patients than the NDR patients (P=0.004, P=0.004, and P=0.003, respectively), while conversely, MBR in the overall optic nerve head (MBR-A) was lower in the mild NPDR patients. Furthermore, a logistic regression analysis showed that diabetes duration (OR, 1.11; P=0.006), diastolic blood pressure (OR, 0.93; P=0.025), heart rate (OR, 1.07; P=0.004), IMT (OR, 8.65; P=0.005), and CMT (OR, 1.03; P=0.007) were independent contributing factors to mild NPDR. Spearman’s rank correlation test also showed that IMT was negatively correlated with MBR-A (P=0.011). Conclusions. Increased IMT showed a close association with ocular ischemia in patients with type-2 diabetes and contributed to the presence of mild NPDR. These findings suggest that IMT may be an early biomarker of mild NPDR.http://dx.doi.org/10.1155/2019/3421305 |
| spellingShingle | Kohei Ichinohasama Hiroshi Kunikata Azusa Ito Masayuki Yasuda Shojiro Sawada Keiichi Kondo Chihiro Satake Hideki Katagiri Toru Nakazawa The Relationship between Carotid Intima-Media Thickness and Ocular Circulation in Type-2 Diabetes Journal of Ophthalmology |
| title | The Relationship between Carotid Intima-Media Thickness and Ocular Circulation in Type-2 Diabetes |
| title_full | The Relationship between Carotid Intima-Media Thickness and Ocular Circulation in Type-2 Diabetes |
| title_fullStr | The Relationship between Carotid Intima-Media Thickness and Ocular Circulation in Type-2 Diabetes |
| title_full_unstemmed | The Relationship between Carotid Intima-Media Thickness and Ocular Circulation in Type-2 Diabetes |
| title_short | The Relationship between Carotid Intima-Media Thickness and Ocular Circulation in Type-2 Diabetes |
| title_sort | relationship between carotid intima media thickness and ocular circulation in type 2 diabetes |
| url | http://dx.doi.org/10.1155/2019/3421305 |
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