Pulmonary hypertension in infants with congenital heart defects: are leukotrienes involved?
The circulating levels of leukotriene E4 in infants with congenital heart defects, increased pulmonary blood flow and pulmonary arterial hypertension, were determined and compared with infants with decreased pulmonary blood flow (Tetralogy of Fallot). There was no correlation (r=0.38) between the pu...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1997-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1080/09629359791451 |
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| _version_ | 1832555478840770560 |
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| author | A. Serraf J-P. Gascard J. Bruniaux C. Labat C. Planche C. Brink |
| author_facet | A. Serraf J-P. Gascard J. Bruniaux C. Labat C. Planche C. Brink |
| author_sort | A. Serraf |
| collection | DOAJ |
| description | The circulating levels of leukotriene E4 in infants with congenital heart defects, increased pulmonary blood flow and pulmonary arterial hypertension, were determined and compared with infants with decreased pulmonary blood flow (Tetralogy of Fallot). There was no correlation (r=0.38) between the pulmonary arterial pressure
(56 ± 4 mmHg) and the leukotriene E4 levels (1.37 ± 0.67 ng/ml blood) measured in peripheral blood samples from the hypertensive group prior to surgery. There was considerable variation in the detectable leukotriene E4 levels in blood samples from different patients. The levels detected in the blood samples between the two groups of patients was similar. These data suggest that neither the surgical repair during cardiopulmonary bypass nor the pulmonary hypertension appeared to modify the leukotriene E4 blood levels in the small number of patients studied. |
| format | Article |
| id | doaj-art-8b103baa553a4d9690ba9b152cf2d33f |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1997-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-8b103baa553a4d9690ba9b152cf2d33f2025-02-03T05:48:10ZengWileyMediators of Inflammation0962-93511466-18611997-01-0165-632332610.1080/09629359791451Pulmonary hypertension in infants with congenital heart defects: are leukotrienes involved?A. Serraf0J-P. Gascard1J. Bruniaux2C. Labat3C. Planche4C. Brink5Service de Chirurgie et Réanimation Cardiaques Pédiatriques, Centre Chirurgical Marie-Lannelongue, 133, avenue de la Résistance, Le Plessis-Robinson, 92350, FranceCNRS ERS 566, Centre Chirurgical Marie-Lannelongue, 133, avenue de la Résistance, Le Plessis-Robinson, 92350, USAService de Chirurgie et Réanimation Cardiaques Pédiatriques, Centre Chirurgical Marie-Lannelongue, 133, avenue de la Résistance, Le Plessis-Robinson, 92350, FranceCNRS ERS 566, Centre Chirurgical Marie-Lannelongue, 133, avenue de la Résistance, Le Plessis-Robinson, 92350, USAService de Chirurgie et Réanimation Cardiaques Pédiatriques, Centre Chirurgical Marie-Lannelongue, 133, avenue de la Résistance, Le Plessis-Robinson, 92350, FranceCNRS ERS 566, Centre Chirurgical Marie-Lannelongue, 133, avenue de la Résistance, Le Plessis-Robinson, 92350, USAThe circulating levels of leukotriene E4 in infants with congenital heart defects, increased pulmonary blood flow and pulmonary arterial hypertension, were determined and compared with infants with decreased pulmonary blood flow (Tetralogy of Fallot). There was no correlation (r=0.38) between the pulmonary arterial pressure (56 ± 4 mmHg) and the leukotriene E4 levels (1.37 ± 0.67 ng/ml blood) measured in peripheral blood samples from the hypertensive group prior to surgery. There was considerable variation in the detectable leukotriene E4 levels in blood samples from different patients. The levels detected in the blood samples between the two groups of patients was similar. These data suggest that neither the surgical repair during cardiopulmonary bypass nor the pulmonary hypertension appeared to modify the leukotriene E4 blood levels in the small number of patients studied.http://dx.doi.org/10.1080/09629359791451 |
| spellingShingle | A. Serraf J-P. Gascard J. Bruniaux C. Labat C. Planche C. Brink Pulmonary hypertension in infants with congenital heart defects: are leukotrienes involved? Mediators of Inflammation |
| title | Pulmonary hypertension in infants with congenital heart defects: are leukotrienes involved? |
| title_full | Pulmonary hypertension in infants with congenital heart defects: are leukotrienes involved? |
| title_fullStr | Pulmonary hypertension in infants with congenital heart defects: are leukotrienes involved? |
| title_full_unstemmed | Pulmonary hypertension in infants with congenital heart defects: are leukotrienes involved? |
| title_short | Pulmonary hypertension in infants with congenital heart defects: are leukotrienes involved? |
| title_sort | pulmonary hypertension in infants with congenital heart defects are leukotrienes involved |
| url | http://dx.doi.org/10.1080/09629359791451 |
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