Advancements and Challenges in Immune Protection Strategies for Islet Transplantation
ABSTRACT Pancreatic islet transplantation is a crucial treatment for managing type 1 diabetes (T1D) in clinical settings. However, the limited availability of human cadaveric islet donors and the need for ongoing administration of immunosuppressive agents post‐transplantation hinder the widespread u...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Journal of Diabetes |
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| Online Access: | https://doi.org/10.1111/1753-0407.70048 |
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| author | Xue Wang Ziyuan Zeng Dayan Li Kai Wang Wei Zhang Yang Yu Xi Wang |
| author_facet | Xue Wang Ziyuan Zeng Dayan Li Kai Wang Wei Zhang Yang Yu Xi Wang |
| author_sort | Xue Wang |
| collection | DOAJ |
| description | ABSTRACT Pancreatic islet transplantation is a crucial treatment for managing type 1 diabetes (T1D) in clinical settings. However, the limited availability of human cadaveric islet donors and the need for ongoing administration of immunosuppressive agents post‐transplantation hinder the widespread use of this treatment. Stem cell‐derived islet organoids have emerged as an effective alternative to primary human islets. Nevertheless, implementing this cell replacement therapy still requires chronic immune suppression, which may result in life‐long side effects. To address these challenges, innovations such as encapsulation devices, universal stem cells, and immunomodulatory strategies are being developed to mitigate immune rejection and prolong the function of the transplant. This review outlines the contemporary challenges in pancreatic β cell therapy, particularly immune rejection, and recent progress in immune‐isolation devices, hypoimmunogenic stem cells, and immune regulation of transplants. A comprehensive evaluation of the advantages and limitations of these approaches will contribute to improved future clinical investigations. With these promising advancements, the application of pancreatic β cell therapy holds the potential to effectively treat T1D and benefit a larger population of T1D patients. |
| format | Article |
| id | doaj-art-8b046d93db8545b699bb0fa3e97c387a |
| institution | Kabale University |
| issn | 1753-0393 1753-0407 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes |
| spelling | doaj-art-8b046d93db8545b699bb0fa3e97c387a2025-01-28T04:44:58ZengWileyJournal of Diabetes1753-03931753-04072025-01-01171n/an/a10.1111/1753-0407.70048Advancements and Challenges in Immune Protection Strategies for Islet TransplantationXue Wang0Ziyuan Zeng1Dayan Li2Kai Wang3Wei Zhang4Yang Yu5Xi Wang6State Key Laboratory of Female Fertility Promotion, Department of Obstetrics and Gynecology, Clinical Stem Cell Research Center Peking University Third Hospital Beijing ChinaState Key Laboratory of Female Fertility Promotion, Department of Obstetrics and Gynecology, Clinical Stem Cell Research Center Peking University Third Hospital Beijing ChinaDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling Clinical Stem Cell Research Center, Peking University Third Hospital, Peking University Beijing ChinaDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling Clinical Stem Cell Research Center, Peking University Third Hospital, Peking University Beijing ChinaTianXinFu (Beijing) Medical Appliance co. Ltd. Beijing ChinaState Key Laboratory of Female Fertility Promotion, Department of Obstetrics and Gynecology, Clinical Stem Cell Research Center Peking University Third Hospital Beijing ChinaState Key Laboratory of Female Fertility Promotion, Department of Obstetrics and Gynecology, Clinical Stem Cell Research Center Peking University Third Hospital Beijing ChinaABSTRACT Pancreatic islet transplantation is a crucial treatment for managing type 1 diabetes (T1D) in clinical settings. However, the limited availability of human cadaveric islet donors and the need for ongoing administration of immunosuppressive agents post‐transplantation hinder the widespread use of this treatment. Stem cell‐derived islet organoids have emerged as an effective alternative to primary human islets. Nevertheless, implementing this cell replacement therapy still requires chronic immune suppression, which may result in life‐long side effects. To address these challenges, innovations such as encapsulation devices, universal stem cells, and immunomodulatory strategies are being developed to mitigate immune rejection and prolong the function of the transplant. This review outlines the contemporary challenges in pancreatic β cell therapy, particularly immune rejection, and recent progress in immune‐isolation devices, hypoimmunogenic stem cells, and immune regulation of transplants. A comprehensive evaluation of the advantages and limitations of these approaches will contribute to improved future clinical investigations. With these promising advancements, the application of pancreatic β cell therapy holds the potential to effectively treat T1D and benefit a larger population of T1D patients.https://doi.org/10.1111/1753-0407.70048encapsulationimmune rejectionimmunomodulatory strategiespancreatic islet transplantationtype 1 diabetes (T1D) |
| spellingShingle | Xue Wang Ziyuan Zeng Dayan Li Kai Wang Wei Zhang Yang Yu Xi Wang Advancements and Challenges in Immune Protection Strategies for Islet Transplantation Journal of Diabetes encapsulation immune rejection immunomodulatory strategies pancreatic islet transplantation type 1 diabetes (T1D) |
| title | Advancements and Challenges in Immune Protection Strategies for Islet Transplantation |
| title_full | Advancements and Challenges in Immune Protection Strategies for Islet Transplantation |
| title_fullStr | Advancements and Challenges in Immune Protection Strategies for Islet Transplantation |
| title_full_unstemmed | Advancements and Challenges in Immune Protection Strategies for Islet Transplantation |
| title_short | Advancements and Challenges in Immune Protection Strategies for Islet Transplantation |
| title_sort | advancements and challenges in immune protection strategies for islet transplantation |
| topic | encapsulation immune rejection immunomodulatory strategies pancreatic islet transplantation type 1 diabetes (T1D) |
| url | https://doi.org/10.1111/1753-0407.70048 |
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