The Protective Effects of Melatonin on Hainan Black Goats Under Heat Stress: Understanding Its Actions and Mechanisms
As the global climate changes, high temperatures will cause heat stress, which significantly affects the productive efficiency of livestock. Currently, there is a lack of efficient methods to use in targeting this issue. In this study, we report that melatonin supplementation may represent an altern...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/14/1/44 |
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| author | Hao Wu Baochun Qin Guang Yang Pengyun Ji Yu Gao Lu Zhang Bingyuan Wang Guoshi Liu |
| author_facet | Hao Wu Baochun Qin Guang Yang Pengyun Ji Yu Gao Lu Zhang Bingyuan Wang Guoshi Liu |
| author_sort | Hao Wu |
| collection | DOAJ |
| description | As the global climate changes, high temperatures will cause heat stress, which significantly affects the productive efficiency of livestock. Currently, there is a lack of efficient methods to use in targeting this issue. In this study, we report that melatonin supplementation may represent an alternative method to reduce the negative impact of heat stress on livestock, particularly in Hainan black goats. Our results show that melatonin treatment increased the average daily gain of Hainan black goats that were exposed to constantly high temperatures for two months compared to controls. Our mechanistic exploration revealed that melatonin treatment not only reduced the oxidative stress and inflammatory reaction caused by heat stress but also improved goats’ metabolic capacity, promoting their growth and development. More importantly, for the first time, we observed that melatonin treatment modified the abundance of the intestinal microflora, altering the metabolism of the goats, which further improved their tolerance to constant heat stress. |
| format | Article |
| id | doaj-art-8af5b8db3ab84e1485b0e384a53144b0 |
| institution | Kabale University |
| issn | 2076-3921 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj-art-8af5b8db3ab84e1485b0e384a53144b02025-01-24T13:19:17ZengMDPI AGAntioxidants2076-39212025-01-011414410.3390/antiox14010044The Protective Effects of Melatonin on Hainan Black Goats Under Heat Stress: Understanding Its Actions and MechanismsHao Wu0Baochun Qin1Guang Yang2Pengyun Ji3Yu Gao4Lu Zhang5Bingyuan Wang6Guoshi Liu7Sany Institute of China Agricultural University, Sanya 572025, ChinaSany Institute of China Agricultural University, Sanya 572025, ChinaSany Institute of China Agricultural University, Sanya 572025, ChinaNational Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics and Breeding of the Ministry of Agricultural, Beijing Key Laboratory for Animal Genetic Improvement, College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaNational Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics and Breeding of the Ministry of Agricultural, Beijing Key Laboratory for Animal Genetic Improvement, College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaNational Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics and Breeding of the Ministry of Agricultural, Beijing Key Laboratory for Animal Genetic Improvement, College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaNational Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics and Breeding of the Ministry of Agricultural, Beijing Key Laboratory for Animal Genetic Improvement, College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaSany Institute of China Agricultural University, Sanya 572025, ChinaAs the global climate changes, high temperatures will cause heat stress, which significantly affects the productive efficiency of livestock. Currently, there is a lack of efficient methods to use in targeting this issue. In this study, we report that melatonin supplementation may represent an alternative method to reduce the negative impact of heat stress on livestock, particularly in Hainan black goats. Our results show that melatonin treatment increased the average daily gain of Hainan black goats that were exposed to constantly high temperatures for two months compared to controls. Our mechanistic exploration revealed that melatonin treatment not only reduced the oxidative stress and inflammatory reaction caused by heat stress but also improved goats’ metabolic capacity, promoting their growth and development. More importantly, for the first time, we observed that melatonin treatment modified the abundance of the intestinal microflora, altering the metabolism of the goats, which further improved their tolerance to constant heat stress.https://www.mdpi.com/2076-3921/14/1/44heat stressHainan black goatmelatoninmetabolomemetagenome, microbiota |
| spellingShingle | Hao Wu Baochun Qin Guang Yang Pengyun Ji Yu Gao Lu Zhang Bingyuan Wang Guoshi Liu The Protective Effects of Melatonin on Hainan Black Goats Under Heat Stress: Understanding Its Actions and Mechanisms Antioxidants heat stress Hainan black goat melatonin metabolome metagenome, microbiota |
| title | The Protective Effects of Melatonin on Hainan Black Goats Under Heat Stress: Understanding Its Actions and Mechanisms |
| title_full | The Protective Effects of Melatonin on Hainan Black Goats Under Heat Stress: Understanding Its Actions and Mechanisms |
| title_fullStr | The Protective Effects of Melatonin on Hainan Black Goats Under Heat Stress: Understanding Its Actions and Mechanisms |
| title_full_unstemmed | The Protective Effects of Melatonin on Hainan Black Goats Under Heat Stress: Understanding Its Actions and Mechanisms |
| title_short | The Protective Effects of Melatonin on Hainan Black Goats Under Heat Stress: Understanding Its Actions and Mechanisms |
| title_sort | protective effects of melatonin on hainan black goats under heat stress understanding its actions and mechanisms |
| topic | heat stress Hainan black goat melatonin metabolome metagenome, microbiota |
| url | https://www.mdpi.com/2076-3921/14/1/44 |
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