Phosphorylation-dependent WRN-RPA interaction promotes recovery of stalled forks at secondary DNA structure

Phosphorylation-dependent WRN-RPA interaction promotes recovery of stalled forks at secondary DNA structure

Abstract The WRN protein is vital for managing perturbed replication forks. Replication Protein A strongly enhances WRN helicase activity in specific in vitro assays. However, the in vivo significance of RPA binding to WRN has largely remained unexplored. We identify several conserved phosphorylatio...

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Main Authors: Alessandro Noto, Pasquale Valenzisi, Flavia Di Feo, Federica Fratini, Tomasz Kulikowicz, Joshua A. Sommers, Benedetta Perdichizzi, Maurizio Semproni, Valentina Palermo, Marco Crescenzi, Robert M. Brosh Jr, Annapaola Franchitto, Pietro Pichierri
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-55958-z
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