Potentials of Presepsin as a Novel Sepsis Biomarker in Critically Ill Adults: Correlation Analysis with the Current Diagnostic Markers
<b>Background:</b> Sepsis is a major cause of patient death in intensive care units (ICUs). Rapid diagnosis of sepsis assists in optimizing treatments and improves outcomes. Several biomarkers are employed to aid in the diagnosis, prognostication, severity grading, and sub-type discrimin...
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MDPI AG
2025-01-01
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| author | Mai S. Sater Nourah Almansour Zainab Hasan Abdulla Malalla Salim Fredericks Muhalab E. Ali Hayder A. Giha |
| author_facet | Mai S. Sater Nourah Almansour Zainab Hasan Abdulla Malalla Salim Fredericks Muhalab E. Ali Hayder A. Giha |
| author_sort | Mai S. Sater |
| collection | DOAJ |
| description | <b>Background:</b> Sepsis is a major cause of patient death in intensive care units (ICUs). Rapid diagnosis of sepsis assists in optimizing treatments and improves outcomes. Several biomarkers are employed to aid in the diagnosis, prognostication, severity grading, and sub-type discrimination of severe septic infections (SSIs), including current diagnostic parameters, hemostatic measures, and specific organ dysfunction markers. <b>Methods:</b> This study involved 129 critically ill adults categorized into three groups: sepsis (Se = 48), pneumonia (Pn = 48), and Se/Pn (33). Concentrations of five plasma markers (IL-6, IL-8, TREM1, uPAR, and presepsin) were compared with 13 well-established measures of SSI in critically ill patients. These measures were heart rate (HR), white blood count (WBC), C-reactive protein (CRP), procalcitonin (PCT), lactate plasma concentrations, and measures of hemostasis status (platelets count (PLT), fibrinogen, prothrombin time (PT), activated partial thromboplastin time (APTT), international normalization ratio (INR) and D-dimer). Plasma bilirubin and creatinine served as indicators of liver and kidney dysfunction, respectively. <b>Results:</b> Promising roles for these biomarkers were found. The best results were for presepsin, which scored 10/13, followed by IL-6 and IL-8 (each scored 7/13), and the worst were for TREM-1 and uPAR (scored 3/13). Presepsin, IL-6, and IL-8 discriminated between the SSI sub-types, whilst only presepsin correlated with bilirubin and creatinine. uPAR was positive for kidney dysfunction, and TREM-1 was the only indicator of artificial ventilation (AV). <b>Conclusions:</b> Presepsin is an important potential biomarker in SSIs. However, further work is needed to define this marker’s diagnostic and prognostic cutoff values. |
| format | Article |
| id | doaj-art-8aba9f97158f429f976e6cd35960be59 |
| institution | Kabale University |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj-art-8aba9f97158f429f976e6cd35960be592025-01-24T13:29:09ZengMDPI AGDiagnostics2075-44182025-01-0115221710.3390/diagnostics15020217Potentials of Presepsin as a Novel Sepsis Biomarker in Critically Ill Adults: Correlation Analysis with the Current Diagnostic MarkersMai S. Sater0Nourah Almansour1Zainab Hasan Abdulla Malalla2Salim Fredericks3Muhalab E. Ali4Hayder A. Giha5Department of Medical Biochemistry, College of Medicine and Medical Sciences (CMMS), Arabian Gulf University (AGU), Manama 293, BahrainImmunology and Microbiology Department, Dasman Diabetes Institute, Dasman 15462, KuwaitDepartment of Medical Biochemistry, College of Medicine and Medical Sciences (CMMS), Arabian Gulf University (AGU), Manama 293, BahrainDepartment of Biochemistry, Royal College of Surgeons in Ireland–Medical University of Bahrain (RCSI-MUB), Busaiteen 228, BahrainDepartment of Medical Biochemistry, College of Medicine and Medical Sciences (CMMS), Arabian Gulf University (AGU), Manama 293, BahrainMedical Biochemistry and Molecular Biology, Khartoum, Sudan<b>Background:</b> Sepsis is a major cause of patient death in intensive care units (ICUs). Rapid diagnosis of sepsis assists in optimizing treatments and improves outcomes. Several biomarkers are employed to aid in the diagnosis, prognostication, severity grading, and sub-type discrimination of severe septic infections (SSIs), including current diagnostic parameters, hemostatic measures, and specific organ dysfunction markers. <b>Methods:</b> This study involved 129 critically ill adults categorized into three groups: sepsis (Se = 48), pneumonia (Pn = 48), and Se/Pn (33). Concentrations of five plasma markers (IL-6, IL-8, TREM1, uPAR, and presepsin) were compared with 13 well-established measures of SSI in critically ill patients. These measures were heart rate (HR), white blood count (WBC), C-reactive protein (CRP), procalcitonin (PCT), lactate plasma concentrations, and measures of hemostasis status (platelets count (PLT), fibrinogen, prothrombin time (PT), activated partial thromboplastin time (APTT), international normalization ratio (INR) and D-dimer). Plasma bilirubin and creatinine served as indicators of liver and kidney dysfunction, respectively. <b>Results:</b> Promising roles for these biomarkers were found. The best results were for presepsin, which scored 10/13, followed by IL-6 and IL-8 (each scored 7/13), and the worst were for TREM-1 and uPAR (scored 3/13). Presepsin, IL-6, and IL-8 discriminated between the SSI sub-types, whilst only presepsin correlated with bilirubin and creatinine. uPAR was positive for kidney dysfunction, and TREM-1 was the only indicator of artificial ventilation (AV). <b>Conclusions:</b> Presepsin is an important potential biomarker in SSIs. However, further work is needed to define this marker’s diagnostic and prognostic cutoff values.https://www.mdpi.com/2075-4418/15/2/217sepsiscritically ill patientsdiagnosisbiomarkerspresepsincytokines |
| spellingShingle | Mai S. Sater Nourah Almansour Zainab Hasan Abdulla Malalla Salim Fredericks Muhalab E. Ali Hayder A. Giha Potentials of Presepsin as a Novel Sepsis Biomarker in Critically Ill Adults: Correlation Analysis with the Current Diagnostic Markers Diagnostics sepsis critically ill patients diagnosis biomarkers presepsin cytokines |
| title | Potentials of Presepsin as a Novel Sepsis Biomarker in Critically Ill Adults: Correlation Analysis with the Current Diagnostic Markers |
| title_full | Potentials of Presepsin as a Novel Sepsis Biomarker in Critically Ill Adults: Correlation Analysis with the Current Diagnostic Markers |
| title_fullStr | Potentials of Presepsin as a Novel Sepsis Biomarker in Critically Ill Adults: Correlation Analysis with the Current Diagnostic Markers |
| title_full_unstemmed | Potentials of Presepsin as a Novel Sepsis Biomarker in Critically Ill Adults: Correlation Analysis with the Current Diagnostic Markers |
| title_short | Potentials of Presepsin as a Novel Sepsis Biomarker in Critically Ill Adults: Correlation Analysis with the Current Diagnostic Markers |
| title_sort | potentials of presepsin as a novel sepsis biomarker in critically ill adults correlation analysis with the current diagnostic markers |
| topic | sepsis critically ill patients diagnosis biomarkers presepsin cytokines |
| url | https://www.mdpi.com/2075-4418/15/2/217 |
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