Associations of serum sLOX-1 levels with disease severity and 3-month function prognosis after spontaneous intracerebral hemorrhage: a prospective cohort study
BackgroundSoluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) may be involved in the inflammatory response and aggravate secondary brain injury after spontaneous intracerebral hemorrhage (sICH). The aim of this study was to reveal the association of serum sLOX-1 levels with dise...
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1521774/full |
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| author | Xiufeng Ye Heng He Huan Song Jing Huang Zhixing Zhang Yan Zhou |
| author_facet | Xiufeng Ye Heng He Huan Song Jing Huang Zhixing Zhang Yan Zhou |
| author_sort | Xiufeng Ye |
| collection | DOAJ |
| description | BackgroundSoluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) may be involved in the inflammatory response and aggravate secondary brain injury after spontaneous intracerebral hemorrhage (sICH). The aim of this study was to reveal the association of serum sLOX-1 levels with disease severity and the predictive power of 90-day neurological outcomes after sICH.MethodThis prospective cohort study included 118 sICH patients and 118 healthy controls, whose serum sLOX-1 levels were quantified. Glasgow Coma Scale (GCS) scores and hematoma volumes were used to assess disease severity. Glasgow Outcome Scale (GOS) scores were used to assess 3-month function prognosis after stroke. The relation of serum sLOX-1 levels to disease severity and prognosis (GOS scores 1–3) was discerned Receiver operating characteristic curve was built to evaluate the prognostic predictive capability.ResultSerum sLOX-1 levels were significantly increased in patients compared to healthy controls, and were independently correlated with GCS scores (ρ = −0.577, p < 0.001; t = −6.732, p < 0.001) and hematoma volumes (ρ = 0.540, p < 0.001; t = 7.136, p < 0.001). Patients with poor prognosis have higher serum sLOX-1 levels than in those with good prognosis (p < 0.001). Serum sLOX-1 levels >1539.75 pg/mL distinguished the risk of poor prognosis at 3 months after stroke, with a sensitivity of 83.72% and a specificity of 72.00% (area under curve, 0.813; 95% confidence interval (CI), 0.731–0.879, p < 0.001). Serum sLOX-1 levels were independently associated with poor 3-month prognosis with odds ratio of 1.002 (95% CI, 1.000–1.004).ConclusionSerum sLOX-1 levels are obviously increased after stroke and are significantly associated with disease severity and poor prognosis. Hence, sLOX-1 may serve as a useful potential prognostic biomarker for sICH. |
| format | Article |
| id | doaj-art-8aaaba4ced23450d97df0b656d7fdb34 |
| institution | OA Journals |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj-art-8aaaba4ced23450d97df0b656d7fdb342025-08-20T02:04:37ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-03-011610.3389/fneur.2025.15217741521774Associations of serum sLOX-1 levels with disease severity and 3-month function prognosis after spontaneous intracerebral hemorrhage: a prospective cohort studyXiufeng Ye0Heng He1Huan Song2Jing Huang3Zhixing Zhang4Yan Zhou5Department of Neurosurgery, Longquan People’s Hospital, Lishui, ChinaDepartment of Neurosurgery, Lishui City People’s Hospital, Lishui Hospital of Wenzhou Medical University, Lishui, ChinaDepartment of Neurosurgery, Longquan People’s Hospital, Lishui, ChinaDepartment of Neurosurgery, Longquan People’s Hospital, Lishui, ChinaDepartment of Neurosurgery, Jinyun County Hospital of Traditional Chinese Medicine, Yuncheng, ChinaDepartment of Neurosurgery, Longquan People’s Hospital, Lishui, ChinaBackgroundSoluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) may be involved in the inflammatory response and aggravate secondary brain injury after spontaneous intracerebral hemorrhage (sICH). The aim of this study was to reveal the association of serum sLOX-1 levels with disease severity and the predictive power of 90-day neurological outcomes after sICH.MethodThis prospective cohort study included 118 sICH patients and 118 healthy controls, whose serum sLOX-1 levels were quantified. Glasgow Coma Scale (GCS) scores and hematoma volumes were used to assess disease severity. Glasgow Outcome Scale (GOS) scores were used to assess 3-month function prognosis after stroke. The relation of serum sLOX-1 levels to disease severity and prognosis (GOS scores 1–3) was discerned Receiver operating characteristic curve was built to evaluate the prognostic predictive capability.ResultSerum sLOX-1 levels were significantly increased in patients compared to healthy controls, and were independently correlated with GCS scores (ρ = −0.577, p < 0.001; t = −6.732, p < 0.001) and hematoma volumes (ρ = 0.540, p < 0.001; t = 7.136, p < 0.001). Patients with poor prognosis have higher serum sLOX-1 levels than in those with good prognosis (p < 0.001). Serum sLOX-1 levels >1539.75 pg/mL distinguished the risk of poor prognosis at 3 months after stroke, with a sensitivity of 83.72% and a specificity of 72.00% (area under curve, 0.813; 95% confidence interval (CI), 0.731–0.879, p < 0.001). Serum sLOX-1 levels were independently associated with poor 3-month prognosis with odds ratio of 1.002 (95% CI, 1.000–1.004).ConclusionSerum sLOX-1 levels are obviously increased after stroke and are significantly associated with disease severity and poor prognosis. Hence, sLOX-1 may serve as a useful potential prognostic biomarker for sICH.https://www.frontiersin.org/articles/10.3389/fneur.2025.1521774/fullspontaneous intracerebral hemorrhagebiomarkerprognosissoluble lectin-like oxidized low-density lipoprotein receptor-1severity |
| spellingShingle | Xiufeng Ye Heng He Huan Song Jing Huang Zhixing Zhang Yan Zhou Associations of serum sLOX-1 levels with disease severity and 3-month function prognosis after spontaneous intracerebral hemorrhage: a prospective cohort study Frontiers in Neurology spontaneous intracerebral hemorrhage biomarker prognosis soluble lectin-like oxidized low-density lipoprotein receptor-1 severity |
| title | Associations of serum sLOX-1 levels with disease severity and 3-month function prognosis after spontaneous intracerebral hemorrhage: a prospective cohort study |
| title_full | Associations of serum sLOX-1 levels with disease severity and 3-month function prognosis after spontaneous intracerebral hemorrhage: a prospective cohort study |
| title_fullStr | Associations of serum sLOX-1 levels with disease severity and 3-month function prognosis after spontaneous intracerebral hemorrhage: a prospective cohort study |
| title_full_unstemmed | Associations of serum sLOX-1 levels with disease severity and 3-month function prognosis after spontaneous intracerebral hemorrhage: a prospective cohort study |
| title_short | Associations of serum sLOX-1 levels with disease severity and 3-month function prognosis after spontaneous intracerebral hemorrhage: a prospective cohort study |
| title_sort | associations of serum slox 1 levels with disease severity and 3 month function prognosis after spontaneous intracerebral hemorrhage a prospective cohort study |
| topic | spontaneous intracerebral hemorrhage biomarker prognosis soluble lectin-like oxidized low-density lipoprotein receptor-1 severity |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1521774/full |
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