Prevention and Treatment of Osteoporosis Using Chinese Medicinal Plants: Special Emphasis on Mechanisms of Immune Modulation
Numerous studies have examined the pathogenesis of osteoporosis. The causes of osteoporosis include endocrine factors, nutritional status, genetic factors, physical factors, and immune factors. Recent osteoimmunology studies demonstrated that the immune system and immune factors play important regul...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/6345857 |
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| _version_ | 1832568444208283648 |
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| author | Hongyan Zhao Ning Zhao Peng Zheng Xiaohong Xu Meijie Liu Dan Luo Huihui Xu Dahong Ju |
| author_facet | Hongyan Zhao Ning Zhao Peng Zheng Xiaohong Xu Meijie Liu Dan Luo Huihui Xu Dahong Ju |
| author_sort | Hongyan Zhao |
| collection | DOAJ |
| description | Numerous studies have examined the pathogenesis of osteoporosis. The causes of osteoporosis include endocrine factors, nutritional status, genetic factors, physical factors, and immune factors. Recent osteoimmunology studies demonstrated that the immune system and immune factors play important regulatory roles in the occurrence of osteoporosis, and people should pay more attention to the relationship between immunity and osteoporosis. Immune and bone cells are located in the bone marrow and share numerous regulatory molecules, signaling molecules, and transcription factors. Abnormal activation of the immune system alters the balance between osteoblasts and osteoclasts, which results in an imbalance of bone remodeling and osteoporosis. The incidence of osteoporosis is also increasing with the aging of China’s population, and traditional Chinese medicine has played a vital role in the prevention and treatment of osteoporosis for centuries. Chinese medicinal plants possess unique advantages in the regulation of the immune system and the relationships between osteoporosis and the immune system. In this review, we provide a general overview of Chinese medicinal plants in the prevention and treatment of osteoporosis, focusing on immunological aspects. |
| format | Article |
| id | doaj-art-8aa5e5b4ea1e403d8eff285e6b2f9751 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-8aa5e5b4ea1e403d8eff285e6b2f97512025-02-03T00:59:07ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/63458576345857Prevention and Treatment of Osteoporosis Using Chinese Medicinal Plants: Special Emphasis on Mechanisms of Immune ModulationHongyan Zhao0Ning Zhao1Peng Zheng2Xiaohong Xu3Meijie Liu4Dan Luo5Huihui Xu6Dahong Ju7Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, ChinaInstitute of Clinical Basic Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, ChinaJilin Provincial Hospital of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun 130021, ChinaChangchun University of Chinese Medicine, Changchun 130117, ChinaExperimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, ChinaTraditional Chinese Medicine Hospital of Changping District, Beijing 102200, ChinaExperimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, ChinaExperimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, ChinaNumerous studies have examined the pathogenesis of osteoporosis. The causes of osteoporosis include endocrine factors, nutritional status, genetic factors, physical factors, and immune factors. Recent osteoimmunology studies demonstrated that the immune system and immune factors play important regulatory roles in the occurrence of osteoporosis, and people should pay more attention to the relationship between immunity and osteoporosis. Immune and bone cells are located in the bone marrow and share numerous regulatory molecules, signaling molecules, and transcription factors. Abnormal activation of the immune system alters the balance between osteoblasts and osteoclasts, which results in an imbalance of bone remodeling and osteoporosis. The incidence of osteoporosis is also increasing with the aging of China’s population, and traditional Chinese medicine has played a vital role in the prevention and treatment of osteoporosis for centuries. Chinese medicinal plants possess unique advantages in the regulation of the immune system and the relationships between osteoporosis and the immune system. In this review, we provide a general overview of Chinese medicinal plants in the prevention and treatment of osteoporosis, focusing on immunological aspects.http://dx.doi.org/10.1155/2018/6345857 |
| spellingShingle | Hongyan Zhao Ning Zhao Peng Zheng Xiaohong Xu Meijie Liu Dan Luo Huihui Xu Dahong Ju Prevention and Treatment of Osteoporosis Using Chinese Medicinal Plants: Special Emphasis on Mechanisms of Immune Modulation Journal of Immunology Research |
| title | Prevention and Treatment of Osteoporosis Using Chinese Medicinal Plants: Special Emphasis on Mechanisms of Immune Modulation |
| title_full | Prevention and Treatment of Osteoporosis Using Chinese Medicinal Plants: Special Emphasis on Mechanisms of Immune Modulation |
| title_fullStr | Prevention and Treatment of Osteoporosis Using Chinese Medicinal Plants: Special Emphasis on Mechanisms of Immune Modulation |
| title_full_unstemmed | Prevention and Treatment of Osteoporosis Using Chinese Medicinal Plants: Special Emphasis on Mechanisms of Immune Modulation |
| title_short | Prevention and Treatment of Osteoporosis Using Chinese Medicinal Plants: Special Emphasis on Mechanisms of Immune Modulation |
| title_sort | prevention and treatment of osteoporosis using chinese medicinal plants special emphasis on mechanisms of immune modulation |
| url | http://dx.doi.org/10.1155/2018/6345857 |
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