A multifunctional T-cell engager containing CD80 enhances prostate cancer treatment

A multifunctional T-cell engager containing CD80 enhances prostate cancer treatment

Abstract Background T-cell engagers (TCEs), the most extensively studied class of bispecific antibodies, redirect effector T cells to tumor cells to induce immune synapse formation, T-cell activation, and subsequent tumor cell killing. However, their therapeutic efficacy in solid tumors is limited b...

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Bibliographic Details
Main Authors: Disen Nie, Yao Jiang, Hui Li, Keying Zhang, Zhengxuan Li, Tong Lu, Yu Li, Donghui Han, Changhong Shi, Nianzeng Xing, Fa Yang, Weihong Wen, Weijun Qin
Format: Article
Language:English
Published: Springer 2025-07-01
Series:Cancer Immunology, Immunotherapy
Subjects:
T-cell engager
CD80
Prostate cancer
Tri-specific antibodies
PSMA/CD3 antigens
Online Access:https://doi.org/10.1007/s00262-025-04121-0
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