Challenges and opportunities for digital twins in precision medicine from a complex systems perspective
Abstract Digital twins (DTs) in precision medicine are increasingly viable, propelled by extensive data collection and advancements in artificial intelligence (AI), alongside traditional biomedical methodologies. We argue that including mechanistic simulations that produce behavior based on explicit...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | npj Digital Medicine |
| Online Access: | https://doi.org/10.1038/s41746-024-01402-3 |
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| _version_ | 1832594422143909888 |
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| author | Manlio De Domenico Luca Allegri Guido Caldarelli Valeria d’Andrea Barbara Di Camillo Luis M. Rocha Jordan Rozum Riccardo Sbarbati Francesco Zambelli |
| author_facet | Manlio De Domenico Luca Allegri Guido Caldarelli Valeria d’Andrea Barbara Di Camillo Luis M. Rocha Jordan Rozum Riccardo Sbarbati Francesco Zambelli |
| author_sort | Manlio De Domenico |
| collection | DOAJ |
| description | Abstract Digital twins (DTs) in precision medicine are increasingly viable, propelled by extensive data collection and advancements in artificial intelligence (AI), alongside traditional biomedical methodologies. We argue that including mechanistic simulations that produce behavior based on explicitly defined biological hypotheses and multiscale mechanisms is beneficial. It enables the exploration of diverse therapeutic strategies and supports dynamic clinical decision-making through insights from network science, quantitative biology, and digital medicine. |
| format | Article |
| id | doaj-art-8a7704d8b04343b0a94703c1d08d1224 |
| institution | Kabale University |
| issn | 2398-6352 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Digital Medicine |
| spelling | doaj-art-8a7704d8b04343b0a94703c1d08d12242025-01-19T12:39:53ZengNature Portfolionpj Digital Medicine2398-63522025-01-018111110.1038/s41746-024-01402-3Challenges and opportunities for digital twins in precision medicine from a complex systems perspectiveManlio De Domenico0Luca Allegri1Guido Caldarelli2Valeria d’Andrea3Barbara Di Camillo4Luis M. Rocha5Jordan Rozum6Riccardo Sbarbati7Francesco Zambelli8Department of Physics and Astronomy “Galileo Galilei”, University of PaduaDepartment of Physics and Astronomy “Galileo Galilei”, University of PaduaDSMN and ECLT Ca’ Foscari University of VeniceDepartment of Physics and Astronomy “Galileo Galilei”, University of PaduaPadua Center for Network Medicine, University of PaduaSchool of Systems Science and Industrial Eng., Binghamton UniversitySchool of Systems Science and Industrial Eng., Binghamton UniversityDepartment of Physics and Astronomy “Galileo Galilei”, University of PaduaDepartment of Physics and Astronomy “Galileo Galilei”, University of PaduaAbstract Digital twins (DTs) in precision medicine are increasingly viable, propelled by extensive data collection and advancements in artificial intelligence (AI), alongside traditional biomedical methodologies. We argue that including mechanistic simulations that produce behavior based on explicitly defined biological hypotheses and multiscale mechanisms is beneficial. It enables the exploration of diverse therapeutic strategies and supports dynamic clinical decision-making through insights from network science, quantitative biology, and digital medicine.https://doi.org/10.1038/s41746-024-01402-3 |
| spellingShingle | Manlio De Domenico Luca Allegri Guido Caldarelli Valeria d’Andrea Barbara Di Camillo Luis M. Rocha Jordan Rozum Riccardo Sbarbati Francesco Zambelli Challenges and opportunities for digital twins in precision medicine from a complex systems perspective npj Digital Medicine |
| title | Challenges and opportunities for digital twins in precision medicine from a complex systems perspective |
| title_full | Challenges and opportunities for digital twins in precision medicine from a complex systems perspective |
| title_fullStr | Challenges and opportunities for digital twins in precision medicine from a complex systems perspective |
| title_full_unstemmed | Challenges and opportunities for digital twins in precision medicine from a complex systems perspective |
| title_short | Challenges and opportunities for digital twins in precision medicine from a complex systems perspective |
| title_sort | challenges and opportunities for digital twins in precision medicine from a complex systems perspective |
| url | https://doi.org/10.1038/s41746-024-01402-3 |
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