The influence of hypertensive disorders in pregnancy on neonatal amino acid and acylcarnitine levels
Background/objectivesHypertensive disorders in pregnancy (HDP) are associated with an increased risk of neonatal complications; however, their effects on neonatal metabolism remain inadequately understood. The aim of this study was to assess the association between HDP and neonatal amino acid and ac...
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1520262/full |
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| author | Shiyi Xu Fei Kong Shuting Huang Qiuping Liao Jinfu Zhou Jinfu Zhou Jinying Luo |
| author_facet | Shiyi Xu Fei Kong Shuting Huang Qiuping Liao Jinfu Zhou Jinfu Zhou Jinying Luo |
| author_sort | Shiyi Xu |
| collection | DOAJ |
| description | Background/objectivesHypertensive disorders in pregnancy (HDP) are associated with an increased risk of neonatal complications; however, their effects on neonatal metabolism remain inadequately understood. The aim of this study was to assess the association between HDP and neonatal amino acid and acylcarnitine levels.MethodsIn this retrospective case–control study, 1,228 singleton pregnant women diagnosed with HDP and 1,228 normal singleton pregnant women whose newborns underwent newborn screening for 11 amino acids and 31 acylcarnitines were recruited from January 2021 to December 2023.ResultsAfter adjusting for potential confounding factors, including gestational age at delivery, birth weight and neonatal sex, nine amino acids exhibited significant differences between infants born to mothers in the HDP subgroups compared to those born to mothers with normal pregnancies. These amino acids were involved in arginine and proline metabolism and the urea cycle pathway. Amino acid levels also varied among the HDP subgroups. Additionally, the levels of short-, medium-, and long-chain acylcarnitines were significantly higher in newborns born to mothers in the HDP subgroups than in newborns born to mothers in the normal pregnancy group. However, no statistically significant differences were observed among the four HDP subgroups.ConclusionOur findings revealed a significant link between HDP and neonatal amino acid and acylcarnitine levels, which were involved in arginine and proline metabolism, the urea cycle, and fatty acid oxidation. These results underscore the significance of identifying maternal conditions that affect newborn metabolites to ensure adequate nutrition and enhance neonatal health outcomes. |
| format | Article |
| id | doaj-art-8a76dbbbefb24fcfbc7326feb2fea881 |
| institution | DOAJ |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
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| spelling | doaj-art-8a76dbbbefb24fcfbc7326feb2fea8812025-08-20T03:07:37ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-08-011210.3389/fnut.2025.15202621520262The influence of hypertensive disorders in pregnancy on neonatal amino acid and acylcarnitine levelsShiyi Xu0Fei Kong1Shuting Huang2Qiuping Liao3Jinfu Zhou4Jinfu Zhou5Jinying Luo6Fujian Maternity and Child Hospital College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, Fuzhou, ChinaDepartment of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou, ChinaDepartment of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou, ChinaDepartment of Obstetrics and Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, Fuzhou, ChinaMedical Genetic Diagnosis and Therapy Center, Fujian Maternity and Child Hospital College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, Fuzhou, ChinaFujian Provincial Key Laboratory for Prenatal Diagnosis and Birth Defect, Fuzhou, ChinaDepartment of Obstetrics and Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, Fuzhou, ChinaBackground/objectivesHypertensive disorders in pregnancy (HDP) are associated with an increased risk of neonatal complications; however, their effects on neonatal metabolism remain inadequately understood. The aim of this study was to assess the association between HDP and neonatal amino acid and acylcarnitine levels.MethodsIn this retrospective case–control study, 1,228 singleton pregnant women diagnosed with HDP and 1,228 normal singleton pregnant women whose newborns underwent newborn screening for 11 amino acids and 31 acylcarnitines were recruited from January 2021 to December 2023.ResultsAfter adjusting for potential confounding factors, including gestational age at delivery, birth weight and neonatal sex, nine amino acids exhibited significant differences between infants born to mothers in the HDP subgroups compared to those born to mothers with normal pregnancies. These amino acids were involved in arginine and proline metabolism and the urea cycle pathway. Amino acid levels also varied among the HDP subgroups. Additionally, the levels of short-, medium-, and long-chain acylcarnitines were significantly higher in newborns born to mothers in the HDP subgroups than in newborns born to mothers in the normal pregnancy group. However, no statistically significant differences were observed among the four HDP subgroups.ConclusionOur findings revealed a significant link between HDP and neonatal amino acid and acylcarnitine levels, which were involved in arginine and proline metabolism, the urea cycle, and fatty acid oxidation. These results underscore the significance of identifying maternal conditions that affect newborn metabolites to ensure adequate nutrition and enhance neonatal health outcomes.https://www.frontiersin.org/articles/10.3389/fnut.2025.1520262/fullhypertensive disorders in pregnancypre-eclampsiagestational hypertensionneonatal metabolismamino acidsacylcarnitines |
| spellingShingle | Shiyi Xu Fei Kong Shuting Huang Qiuping Liao Jinfu Zhou Jinfu Zhou Jinying Luo The influence of hypertensive disorders in pregnancy on neonatal amino acid and acylcarnitine levels Frontiers in Nutrition hypertensive disorders in pregnancy pre-eclampsia gestational hypertension neonatal metabolism amino acids acylcarnitines |
| title | The influence of hypertensive disorders in pregnancy on neonatal amino acid and acylcarnitine levels |
| title_full | The influence of hypertensive disorders in pregnancy on neonatal amino acid and acylcarnitine levels |
| title_fullStr | The influence of hypertensive disorders in pregnancy on neonatal amino acid and acylcarnitine levels |
| title_full_unstemmed | The influence of hypertensive disorders in pregnancy on neonatal amino acid and acylcarnitine levels |
| title_short | The influence of hypertensive disorders in pregnancy on neonatal amino acid and acylcarnitine levels |
| title_sort | influence of hypertensive disorders in pregnancy on neonatal amino acid and acylcarnitine levels |
| topic | hypertensive disorders in pregnancy pre-eclampsia gestational hypertension neonatal metabolism amino acids acylcarnitines |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1520262/full |
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