Predictors of irritability in pediatric autistic populations: a scoping review
IntroductionAutism is characterized by social communication differences and repetitive behaviors, affecting 1%–2% of children. Irritability is a disabling condition affecting 19%–80% of autistic children. While extensive research has focused on interventions to reduce irritability symptoms, the unde...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-07-01
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| Series: | Frontiers in Child and Adolescent Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/frcha.2024.1393231/full |
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| author | Sara Alatrash Sara Alatrash Tithi Paul Julia Carbone Melanie Penner Melanie Penner Atena Roshan Fekr Atena Roshan Fekr Azadeh Kushki Azadeh Kushki |
| author_facet | Sara Alatrash Sara Alatrash Tithi Paul Julia Carbone Melanie Penner Melanie Penner Atena Roshan Fekr Atena Roshan Fekr Azadeh Kushki Azadeh Kushki |
| author_sort | Sara Alatrash |
| collection | DOAJ |
| description | IntroductionAutism is characterized by social communication differences and repetitive behaviors, affecting 1%–2% of children. Irritability is a disabling condition affecting 19%–80% of autistic children. While extensive research has focused on interventions to reduce irritability symptoms, the underlying correlates remain poorly understood. To address this, we conducted a scoping review of the literature examining factors contributing to irritability in pediatric autistic populations.MethodsA literature search of Embase, MEDLINE, PubMed, PsycINFO, and Web of Science was conducted in addition to manually retrieved papers from Google Scholar. Studies underwent title and abstract screening by one reviewer and full-text screening by two reviewers; disagreements were resolved through deliberation. The remaining studies underwent data extraction. The review was conducted using the PRISMA-ScR checklist.ResultsThe search yielded 48 studies meeting the inclusion criteria. Correlates of irritability were categorized into eight themes: demographics/environmental, autism features, mental health, language, cognition, and function, neurobiological, physical health, physiological, and multidimensional factors. Findings revealed mixed associations with demographic factors, consistent positive associations with sensory differences and mental health symptoms, and varying associations with cognitive abilities and physical health factors. Neurobiological and physiological correlates were less explored.ConclusionThis review revealed a significant gap in understanding sociodemographic, phenotypic, and neurobiological and physiological correlates of irritability in autism. There was also a significant gap in understanding the multi-dimensional irritability correlates. Positive associations between irritability and sensory differences and mental health symptoms suggest potential avenues for investigation of non-medication interventions. |
| format | Article |
| id | doaj-art-8a702d95df064e0ea62ebc602e937aa3 |
| institution | Kabale University |
| issn | 2813-4540 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Child and Adolescent Psychiatry |
| spelling | doaj-art-8a702d95df064e0ea62ebc602e937aa32025-01-20T15:17:40ZengFrontiers Media S.A.Frontiers in Child and Adolescent Psychiatry2813-45402024-07-01310.3389/frcha.2024.13932311393231Predictors of irritability in pediatric autistic populations: a scoping reviewSara Alatrash0Sara Alatrash1Tithi Paul2Julia Carbone3Melanie Penner4Melanie Penner5Atena Roshan Fekr6Atena Roshan Fekr7Azadeh Kushki8Azadeh Kushki9Institute of Biomedical Engineering, University of Toronto, Toronto, ON, CanadaBloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON, CanadaBloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON, CanadaBloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON, CanadaBloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON, CanadaDepartment of Paediatrics, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, CanadaInstitute of Biomedical Engineering, University of Toronto, Toronto, ON, CanadaKITE Research Institute, Toronto Rehabilitation Institute, University Health Network, Toronto, ON, CanadaInstitute of Biomedical Engineering, University of Toronto, Toronto, ON, CanadaBloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON, CanadaIntroductionAutism is characterized by social communication differences and repetitive behaviors, affecting 1%–2% of children. Irritability is a disabling condition affecting 19%–80% of autistic children. While extensive research has focused on interventions to reduce irritability symptoms, the underlying correlates remain poorly understood. To address this, we conducted a scoping review of the literature examining factors contributing to irritability in pediatric autistic populations.MethodsA literature search of Embase, MEDLINE, PubMed, PsycINFO, and Web of Science was conducted in addition to manually retrieved papers from Google Scholar. Studies underwent title and abstract screening by one reviewer and full-text screening by two reviewers; disagreements were resolved through deliberation. The remaining studies underwent data extraction. The review was conducted using the PRISMA-ScR checklist.ResultsThe search yielded 48 studies meeting the inclusion criteria. Correlates of irritability were categorized into eight themes: demographics/environmental, autism features, mental health, language, cognition, and function, neurobiological, physical health, physiological, and multidimensional factors. Findings revealed mixed associations with demographic factors, consistent positive associations with sensory differences and mental health symptoms, and varying associations with cognitive abilities and physical health factors. Neurobiological and physiological correlates were less explored.ConclusionThis review revealed a significant gap in understanding sociodemographic, phenotypic, and neurobiological and physiological correlates of irritability in autism. There was also a significant gap in understanding the multi-dimensional irritability correlates. Positive associations between irritability and sensory differences and mental health symptoms suggest potential avenues for investigation of non-medication interventions.https://www.frontiersin.org/articles/10.3389/frcha.2024.1393231/fullautismirritabilitycorrelatepredictorpediatric |
| spellingShingle | Sara Alatrash Sara Alatrash Tithi Paul Julia Carbone Melanie Penner Melanie Penner Atena Roshan Fekr Atena Roshan Fekr Azadeh Kushki Azadeh Kushki Predictors of irritability in pediatric autistic populations: a scoping review Frontiers in Child and Adolescent Psychiatry autism irritability correlate predictor pediatric |
| title | Predictors of irritability in pediatric autistic populations: a scoping review |
| title_full | Predictors of irritability in pediatric autistic populations: a scoping review |
| title_fullStr | Predictors of irritability in pediatric autistic populations: a scoping review |
| title_full_unstemmed | Predictors of irritability in pediatric autistic populations: a scoping review |
| title_short | Predictors of irritability in pediatric autistic populations: a scoping review |
| title_sort | predictors of irritability in pediatric autistic populations a scoping review |
| topic | autism irritability correlate predictor pediatric |
| url | https://www.frontiersin.org/articles/10.3389/frcha.2024.1393231/full |
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