Effects of 8-week Theracurmin Super (TS-P1; curcumin) supplementation on exercise-induced oxidative stress: A randomized double-blind, placebo-controlled parallel clinical trial
Background: Given the antioxidant properties of curcumin, this study aimed to determine the effectiveness and safety of Theracurmin Super supplementation in mitigating exercise-induced oxidative stress in healthy adults. Methods: Seventy-one healthy adults participated in this study, which was condu...
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Elsevier
2025-03-01
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| Series: | Integrative Medicine Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213422024000799 |
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| author | Xinxing Li Dae Young Kim Yunho Sung Donghyun Kim Seohyun Ahn Hyejung Shin Nur Afiqah Binti Zulkifli Ji-won Seo Shu Jiang Parivash Jamrasi SoYoung Ahn Jun Hyun Bae HeeKyung Yeo Hayoung Park Wook Song |
| author_facet | Xinxing Li Dae Young Kim Yunho Sung Donghyun Kim Seohyun Ahn Hyejung Shin Nur Afiqah Binti Zulkifli Ji-won Seo Shu Jiang Parivash Jamrasi SoYoung Ahn Jun Hyun Bae HeeKyung Yeo Hayoung Park Wook Song |
| author_sort | Xinxing Li |
| collection | DOAJ |
| description | Background: Given the antioxidant properties of curcumin, this study aimed to determine the effectiveness and safety of Theracurmin Super supplementation in mitigating exercise-induced oxidative stress in healthy adults. Methods: Seventy-one healthy adults participated in this study, which was conducted at Seoul National University from April 2022 to March 2023. Eligibility was determined during visit 1 through maximum oxygen consumption assessed using the Bruce Treadmill protocol. At visit 2, the participants were randomly allocated to either the Theracurmin Super supplement group (TG, n = 36) or the placebo supplement group (PG, n = 35). Over 8 weeks, the participants consumed Theracurmin Super (curcumin, 120 mg/day) or Placebo (curcumin, 0 mg/day) twice daily and visited the laboratory four times. Various parameters, including body composition, vital signs, nutrition quotient for adults, cardiorespiratory endurance, blood biomarkers, and adverse events, were assessed at each visit. Statistical analyses included per-protocol analysis, t-tests for group and within-group differences, and two-way ANOVA. Results: At week 8, blood biomarkers linked to oxidative stress, including TBARs, MDA, 8-OHdG, SOD, TOS, and OSI, showed significant group- and week-related interactions (total oxidant status: resting state P = 0.021; oxidative stress index, resting state P = 0.020, end of exercise, P = 0.013). Notably, the TG showed a significant decrease in total oxidant status (resting state P = 0.041) and oxidative stress index (resting state P = 0.018 and end of exercise P = 0.008) between weeks 0 and 8. However, MDA and 8-OHdG levels did not show statistically significant changes. Conclusions: Theracurmin Super effectively reduced oxidative stress before and after exercise, highlighting the promising role of curcumin in managing oxidative stress. Significant improvements in TOS and OSI were observed, although changes in MDA and 8-OHdG levels were not statistically significant. Further research could provide insights into these mixed results across different oxidative biomarkers. Trial registration: Clinical Research Information Service (CRIS): KCT0008731. |
| format | Article |
| id | doaj-art-8a6f5a49202e431daaa70db2fc34c42e |
| institution | Kabale University |
| issn | 2213-4220 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Integrative Medicine Research |
| spelling | doaj-art-8a6f5a49202e431daaa70db2fc34c42e2025-08-20T03:42:37ZengElsevierIntegrative Medicine Research2213-42202025-03-0114110109910.1016/j.imr.2024.101099Effects of 8-week Theracurmin Super (TS-P1; curcumin) supplementation on exercise-induced oxidative stress: A randomized double-blind, placebo-controlled parallel clinical trialXinxing Li0Dae Young Kim1Yunho Sung2Donghyun Kim3Seohyun Ahn4Hyejung Shin5Nur Afiqah Binti Zulkifli6Ji-won Seo7Shu Jiang8Parivash Jamrasi9SoYoung Ahn10Jun Hyun Bae11HeeKyung Yeo12Hayoung Park13Wook Song14Health and Exercise Science Laboratory, Department of Physical Education, Seoul National University, Seoul, Korea; Institute on Aging, Seoul National University, Seoul, KoreaHealth and Exercise Science Laboratory, Department of Physical Education, Seoul National University, Seoul, KoreaHealth and Exercise Science Laboratory, Department of Physical Education, Seoul National University, Seoul, KoreaHealth and Exercise Science Laboratory, Department of Physical Education, Seoul National University, Seoul, KoreaHealth and Exercise Science Laboratory, Department of Physical Education, Seoul National University, Seoul, KoreaHealth and Exercise Science Laboratory, Department of Physical Education, Seoul National University, Seoul, KoreaHealth and Exercise Science Laboratory, Department of Physical Education, Seoul National University, Seoul, KoreaHealth and Exercise Science Laboratory, Department of Physical Education, Seoul National University, Seoul, KoreaHealth and Exercise Science Laboratory, Department of Physical Education, Seoul National University, Seoul, KoreaHealth and Exercise Science Laboratory, Department of Physical Education, Seoul National University, Seoul, KoreaHealth and Exercise Science Laboratory, Department of Physical Education, Seoul National University, Seoul, KoreaInstitute on Aging, Seoul National University, Seoul, Korea; Institute of Sport Science, Seoul National University, Seoul, KoreaInstitute on Aging, Seoul National University, Seoul, KoreaConsumer Healthcare, Handok Inc., Seoul, KoreaHealth and Exercise Science Laboratory, Department of Physical Education, Seoul National University, Seoul, Korea; Institute on Aging, Seoul National University, Seoul, Korea; Institute of Sport Science, Seoul National University, Seoul, Korea; Corresponding author at: Health and Exercise Science Laboratory, Department of Physical Education, Seoul National University, Seoul, Republic of Korea.Background: Given the antioxidant properties of curcumin, this study aimed to determine the effectiveness and safety of Theracurmin Super supplementation in mitigating exercise-induced oxidative stress in healthy adults. Methods: Seventy-one healthy adults participated in this study, which was conducted at Seoul National University from April 2022 to March 2023. Eligibility was determined during visit 1 through maximum oxygen consumption assessed using the Bruce Treadmill protocol. At visit 2, the participants were randomly allocated to either the Theracurmin Super supplement group (TG, n = 36) or the placebo supplement group (PG, n = 35). Over 8 weeks, the participants consumed Theracurmin Super (curcumin, 120 mg/day) or Placebo (curcumin, 0 mg/day) twice daily and visited the laboratory four times. Various parameters, including body composition, vital signs, nutrition quotient for adults, cardiorespiratory endurance, blood biomarkers, and adverse events, were assessed at each visit. Statistical analyses included per-protocol analysis, t-tests for group and within-group differences, and two-way ANOVA. Results: At week 8, blood biomarkers linked to oxidative stress, including TBARs, MDA, 8-OHdG, SOD, TOS, and OSI, showed significant group- and week-related interactions (total oxidant status: resting state P = 0.021; oxidative stress index, resting state P = 0.020, end of exercise, P = 0.013). Notably, the TG showed a significant decrease in total oxidant status (resting state P = 0.041) and oxidative stress index (resting state P = 0.018 and end of exercise P = 0.008) between weeks 0 and 8. However, MDA and 8-OHdG levels did not show statistically significant changes. Conclusions: Theracurmin Super effectively reduced oxidative stress before and after exercise, highlighting the promising role of curcumin in managing oxidative stress. Significant improvements in TOS and OSI were observed, although changes in MDA and 8-OHdG levels were not statistically significant. Further research could provide insights into these mixed results across different oxidative biomarkers. Trial registration: Clinical Research Information Service (CRIS): KCT0008731.http://www.sciencedirect.com/science/article/pii/S2213422024000799AntioxidantsCurcuminExerciseOxidative stressTheracurmin super |
| spellingShingle | Xinxing Li Dae Young Kim Yunho Sung Donghyun Kim Seohyun Ahn Hyejung Shin Nur Afiqah Binti Zulkifli Ji-won Seo Shu Jiang Parivash Jamrasi SoYoung Ahn Jun Hyun Bae HeeKyung Yeo Hayoung Park Wook Song Effects of 8-week Theracurmin Super (TS-P1; curcumin) supplementation on exercise-induced oxidative stress: A randomized double-blind, placebo-controlled parallel clinical trial Integrative Medicine Research Antioxidants Curcumin Exercise Oxidative stress Theracurmin super |
| title | Effects of 8-week Theracurmin Super (TS-P1; curcumin) supplementation on exercise-induced oxidative stress: A randomized double-blind, placebo-controlled parallel clinical trial |
| title_full | Effects of 8-week Theracurmin Super (TS-P1; curcumin) supplementation on exercise-induced oxidative stress: A randomized double-blind, placebo-controlled parallel clinical trial |
| title_fullStr | Effects of 8-week Theracurmin Super (TS-P1; curcumin) supplementation on exercise-induced oxidative stress: A randomized double-blind, placebo-controlled parallel clinical trial |
| title_full_unstemmed | Effects of 8-week Theracurmin Super (TS-P1; curcumin) supplementation on exercise-induced oxidative stress: A randomized double-blind, placebo-controlled parallel clinical trial |
| title_short | Effects of 8-week Theracurmin Super (TS-P1; curcumin) supplementation on exercise-induced oxidative stress: A randomized double-blind, placebo-controlled parallel clinical trial |
| title_sort | effects of 8 week theracurmin super ts p1 curcumin supplementation on exercise induced oxidative stress a randomized double blind placebo controlled parallel clinical trial |
| topic | Antioxidants Curcumin Exercise Oxidative stress Theracurmin super |
| url | http://www.sciencedirect.com/science/article/pii/S2213422024000799 |
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