Generation of a new Slc20a2 knockout mouse line as in vivo model for primary brain calcification

Generation of a new Slc20a2 knockout mouse line as in vivo model for primary brain calcification

Abstract Primary brain calcification (PBC) is a neurodegenerative disease that causes bilateral ectopic calcification in the brain. In this study, using newly generated Slc20a2 knockout (Slc20a2 −/−) mice, we establish an in vivo model for PBC. In contrast to heterozygous Slc20a2 +/− mice (9/9 anima...

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Bibliographic Details
Main Authors: Hisaka Kurita, Hiroki Kitaura, Kazuya Nishii, Tomohiko Masaka, Kazuki Ohuchi, Masatoshi Inden, Akiyoshi Kakita, Masatake Osawa, Isao Hozumi
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Molecular Brain
Subjects:
Primary brain calcification
SLC20A2
In vivo model
Online Access:https://doi.org/10.1186/s13041-025-01240-8
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