Frequency and types of antibiotic usage in a referral neonatal intensive care unit, based on the world health organization classification (AwaRe)
Abstract Background Excessive prescription of antibiotics in infants increases the risk of short-term and lifelong morbidity and mortality. Nonetheless, the use of antibiotics in neonatal intensive care units (NICUs) is significantly high. This is primarily because neonatologists are concerned about...
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2025-01-01
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| Online Access: | https://doi.org/10.1186/s12887-025-05407-z |
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| author | Farzaneh Hematian Seyyed Mohammad Hassan Aletayeb Masoud Dehdashtian Mohammad Reza Aramesh Arash Malakian Mahboobeh Sadat Aletayeb |
| author_facet | Farzaneh Hematian Seyyed Mohammad Hassan Aletayeb Masoud Dehdashtian Mohammad Reza Aramesh Arash Malakian Mahboobeh Sadat Aletayeb |
| author_sort | Farzaneh Hematian |
| collection | DOAJ |
| description | Abstract Background Excessive prescription of antibiotics in infants increases the risk of short-term and lifelong morbidity and mortality. Nonetheless, the use of antibiotics in neonatal intensive care units (NICUs) is significantly high. This is primarily because neonatologists are concerned about the fragile immune systems of newborns, their vulnerability to serious infectious diseases, and the challenge of accurately distinguishing between infectious and non-infectious conditions. Method A five-month cross-sectional prospective study was conducted in southwestern Iran’s largest neonatal intensive care unit. This study aimed to evaluate the dose and duration of antibiotic therapy and identify the prescribing pattern of antibiotics based on the Access, Watch, and Reserve (AWaRe) classification recommended by the World Health Organization (WHO). Results Out of 502 examined patient files, antibiotics were prescribed for 483 neonates. The most common drug combinations were ampicillin and amikacin. The mean number and duration of antibiotic administration were 2.14 drugs and 7.78 days, respectively. 84.3% of infants received antibiotics for ten days or less. The mean course of antibiotic prescription for newborns was 1.1, and 83.1% of prescribed antibiotics were from the Access Group. Conclusion The antibiotic prescription rate was high in our study’s department. Most neonates received two antibiotics in one course from the Access group. |
| format | Article |
| id | doaj-art-8a64d20761ac4dab9825e0a3251258f3 |
| institution | Kabale University |
| issn | 1471-2431 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pediatrics |
| spelling | doaj-art-8a64d20761ac4dab9825e0a3251258f32025-01-26T12:52:50ZengBMCBMC Pediatrics1471-24312025-01-012511910.1186/s12887-025-05407-zFrequency and types of antibiotic usage in a referral neonatal intensive care unit, based on the world health organization classification (AwaRe)Farzaneh Hematian0Seyyed Mohammad Hassan Aletayeb1Masoud Dehdashtian2Mohammad Reza Aramesh3Arash Malakian4Mahboobeh Sadat Aletayeb5Department of Clinical Pharmacy, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical SciencesDepartment of Pediatrics, Faculty of Medicine, Imam Khomeini Hospital, Ahvaz Jundishapur University of Medical SciencesDepartment of Pediatrics, Faculty of Medicine, Imam Khomeini Hospital, Ahvaz Jundishapur University of Medical SciencesDepartment of Pediatrics, Faculty of Medicine, Imam Khomeini Hospital, Ahvaz Jundishapur University of Medical SciencesDepartment of Pediatrics, Faculty of Medicine, Imam Khomeini Hospital, Ahvaz Jundishapur University of Medical SciencesStudent Research Committee, Ahvaz Jundishapur University of Medical SciencesAbstract Background Excessive prescription of antibiotics in infants increases the risk of short-term and lifelong morbidity and mortality. Nonetheless, the use of antibiotics in neonatal intensive care units (NICUs) is significantly high. This is primarily because neonatologists are concerned about the fragile immune systems of newborns, their vulnerability to serious infectious diseases, and the challenge of accurately distinguishing between infectious and non-infectious conditions. Method A five-month cross-sectional prospective study was conducted in southwestern Iran’s largest neonatal intensive care unit. This study aimed to evaluate the dose and duration of antibiotic therapy and identify the prescribing pattern of antibiotics based on the Access, Watch, and Reserve (AWaRe) classification recommended by the World Health Organization (WHO). Results Out of 502 examined patient files, antibiotics were prescribed for 483 neonates. The most common drug combinations were ampicillin and amikacin. The mean number and duration of antibiotic administration were 2.14 drugs and 7.78 days, respectively. 84.3% of infants received antibiotics for ten days or less. The mean course of antibiotic prescription for newborns was 1.1, and 83.1% of prescribed antibiotics were from the Access Group. Conclusion The antibiotic prescription rate was high in our study’s department. Most neonates received two antibiotics in one course from the Access group.https://doi.org/10.1186/s12887-025-05407-zNeonatesAntibioticsAwareIran |
| spellingShingle | Farzaneh Hematian Seyyed Mohammad Hassan Aletayeb Masoud Dehdashtian Mohammad Reza Aramesh Arash Malakian Mahboobeh Sadat Aletayeb Frequency and types of antibiotic usage in a referral neonatal intensive care unit, based on the world health organization classification (AwaRe) BMC Pediatrics Neonates Antibiotics Aware Iran |
| title | Frequency and types of antibiotic usage in a referral neonatal intensive care unit, based on the world health organization classification (AwaRe) |
| title_full | Frequency and types of antibiotic usage in a referral neonatal intensive care unit, based on the world health organization classification (AwaRe) |
| title_fullStr | Frequency and types of antibiotic usage in a referral neonatal intensive care unit, based on the world health organization classification (AwaRe) |
| title_full_unstemmed | Frequency and types of antibiotic usage in a referral neonatal intensive care unit, based on the world health organization classification (AwaRe) |
| title_short | Frequency and types of antibiotic usage in a referral neonatal intensive care unit, based on the world health organization classification (AwaRe) |
| title_sort | frequency and types of antibiotic usage in a referral neonatal intensive care unit based on the world health organization classification aware |
| topic | Neonates Antibiotics Aware Iran |
| url | https://doi.org/10.1186/s12887-025-05407-z |
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