Trypanosoma cruzi Infection and Host Lipid Metabolism
Trypanosoma cruzi is the causative agent of Chagas disease. Approximately 8 million people are thought to be affected worldwide. Several players in host lipid metabolism have been implicated in T. cruzi-host interactions in recent research, including macrophages, adipocytes, low density lipoprotein...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/902038 |
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| _version_ | 1832562118190170112 |
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| author | Qianqian Miao Momar Ndao |
| author_facet | Qianqian Miao Momar Ndao |
| author_sort | Qianqian Miao |
| collection | DOAJ |
| description | Trypanosoma cruzi is the causative agent of Chagas disease. Approximately 8 million people are thought to be affected worldwide. Several players in host lipid metabolism have been implicated in T. cruzi-host interactions in recent research, including macrophages, adipocytes, low density lipoprotein (LDL), low density lipoprotein receptor (LDLR), and high density lipoprotein (HDL). All of these factors are required to maintain host lipid homeostasis and are intricately connected via several metabolic pathways. We reviewed the interaction of T. cruzi with each of the relevant host components, in order to further understand the roles of host lipid metabolism in T. cruzi infection. This review sheds light on the potential impact of T. cruzi infection on the status of host lipid homeostasis. |
| format | Article |
| id | doaj-art-8a5667ff637546f7a6945dcd8ca0515d |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-8a5667ff637546f7a6945dcd8ca0515d2025-02-03T01:23:20ZengWileyMediators of Inflammation0962-93511466-18612014-01-01201410.1155/2014/902038902038Trypanosoma cruzi Infection and Host Lipid MetabolismQianqian Miao0Momar Ndao1National Reference Centre for Parasitology, Research Institute of McGill University Health Centre, Montreal General Hospital, Montreal, QC, H3G 1A4, CanadaNational Reference Centre for Parasitology, Research Institute of McGill University Health Centre, Montreal General Hospital, Montreal, QC, H3G 1A4, CanadaTrypanosoma cruzi is the causative agent of Chagas disease. Approximately 8 million people are thought to be affected worldwide. Several players in host lipid metabolism have been implicated in T. cruzi-host interactions in recent research, including macrophages, adipocytes, low density lipoprotein (LDL), low density lipoprotein receptor (LDLR), and high density lipoprotein (HDL). All of these factors are required to maintain host lipid homeostasis and are intricately connected via several metabolic pathways. We reviewed the interaction of T. cruzi with each of the relevant host components, in order to further understand the roles of host lipid metabolism in T. cruzi infection. This review sheds light on the potential impact of T. cruzi infection on the status of host lipid homeostasis.http://dx.doi.org/10.1155/2014/902038 |
| spellingShingle | Qianqian Miao Momar Ndao Trypanosoma cruzi Infection and Host Lipid Metabolism Mediators of Inflammation |
| title | Trypanosoma cruzi Infection and Host Lipid Metabolism |
| title_full | Trypanosoma cruzi Infection and Host Lipid Metabolism |
| title_fullStr | Trypanosoma cruzi Infection and Host Lipid Metabolism |
| title_full_unstemmed | Trypanosoma cruzi Infection and Host Lipid Metabolism |
| title_short | Trypanosoma cruzi Infection and Host Lipid Metabolism |
| title_sort | trypanosoma cruzi infection and host lipid metabolism |
| url | http://dx.doi.org/10.1155/2014/902038 |
| work_keys_str_mv | AT qianqianmiao trypanosomacruziinfectionandhostlipidmetabolism AT momarndao trypanosomacruziinfectionandhostlipidmetabolism |