Indoor Volatile Organic Compounds and Chemical Sensitivity Reactions
Studies of unexplained symptoms observed in chemically sensitive subjects have increased the awareness of the relationship between neurological and immunological diseases due to exposure to volatile organic compounds (VOCs). However, there is no direct evidence that links exposure to low doses of VO...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/623812 |
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| _version_ | 1832548065217609728 |
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| author | Tin-Tin Win-Shwe Hidekazu Fujimaki Keiichi Arashidani Naoki Kunugita |
| author_facet | Tin-Tin Win-Shwe Hidekazu Fujimaki Keiichi Arashidani Naoki Kunugita |
| author_sort | Tin-Tin Win-Shwe |
| collection | DOAJ |
| description | Studies of unexplained symptoms observed in chemically sensitive subjects have increased the awareness of the relationship between neurological and immunological diseases due to exposure to volatile organic compounds (VOCs). However, there is no direct evidence that links exposure to low doses of VOCs and neurological and immunological dysfunction. We review animal model data to clarify the role of VOCs in neuroimmune interactions and discuss our recent studies that show a relationship between chronic exposure of C3H mice to low levels of formaldehyde and the induction of neural and immune dysfunction. We also consider the possible mechanisms by which VOC exposure can induce the symptoms presenting in patients with a multiple chemical sensitivity. |
| format | Article |
| id | doaj-art-8a3efe36472d41698bb7029cd936b45c |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-8a3efe36472d41698bb7029cd936b45c2025-02-03T06:42:21ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/623812623812Indoor Volatile Organic Compounds and Chemical Sensitivity ReactionsTin-Tin Win-Shwe0Hidekazu Fujimaki1Keiichi Arashidani2Naoki Kunugita3Center for Environmental Health Sciences, National Institute for Environmental Studies, Tsukuba, Ibaraki 305-8506, JapanCenter for Environmental Risk Research, National Institute for Environmental Studies, Tsukuba, Ibaraki 305-8506, JapanUniversity of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka 807-8555, JapanDepartment of Environmental Health, National Institute of Public Health, 2-3-6 Minami, Wako City, Saitama 351-0197, JapanStudies of unexplained symptoms observed in chemically sensitive subjects have increased the awareness of the relationship between neurological and immunological diseases due to exposure to volatile organic compounds (VOCs). However, there is no direct evidence that links exposure to low doses of VOCs and neurological and immunological dysfunction. We review animal model data to clarify the role of VOCs in neuroimmune interactions and discuss our recent studies that show a relationship between chronic exposure of C3H mice to low levels of formaldehyde and the induction of neural and immune dysfunction. We also consider the possible mechanisms by which VOC exposure can induce the symptoms presenting in patients with a multiple chemical sensitivity.http://dx.doi.org/10.1155/2013/623812 |
| spellingShingle | Tin-Tin Win-Shwe Hidekazu Fujimaki Keiichi Arashidani Naoki Kunugita Indoor Volatile Organic Compounds and Chemical Sensitivity Reactions Clinical and Developmental Immunology |
| title | Indoor Volatile Organic Compounds and Chemical Sensitivity Reactions |
| title_full | Indoor Volatile Organic Compounds and Chemical Sensitivity Reactions |
| title_fullStr | Indoor Volatile Organic Compounds and Chemical Sensitivity Reactions |
| title_full_unstemmed | Indoor Volatile Organic Compounds and Chemical Sensitivity Reactions |
| title_short | Indoor Volatile Organic Compounds and Chemical Sensitivity Reactions |
| title_sort | indoor volatile organic compounds and chemical sensitivity reactions |
| url | http://dx.doi.org/10.1155/2013/623812 |
| work_keys_str_mv | AT tintinwinshwe indoorvolatileorganiccompoundsandchemicalsensitivityreactions AT hidekazufujimaki indoorvolatileorganiccompoundsandchemicalsensitivityreactions AT keiichiarashidani indoorvolatileorganiccompoundsandchemicalsensitivityreactions AT naokikunugita indoorvolatileorganiccompoundsandchemicalsensitivityreactions |