The causal association of cheese intake with type 2 diabetes mellitus: results from a two-sample Mendelian randomization study
Introduction Worldwide, type 2 diabetes is a major health concern with numerous risk factors. In observational studies, cheese consumption has been linked to type 2 diabetes, but it is still unclear whether this relationship is causal. To evaluate this relationship, we performed a two-sample Mendeli...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Termedia Publishing House
2024-05-01
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| Series: | Archives of Medical Science |
| Subjects: | |
| Online Access: | https://www.archivesofmedicalscience.com/The-causal-association-of-cheese-intake-with-type-2-diabetes-mellitus-results-from,188068,0,2.html |
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| Summary: | Introduction
Worldwide, type 2 diabetes is a major health concern with numerous risk factors. In observational studies, cheese consumption has been linked to type 2 diabetes, but it is still unclear whether this relationship is causal. To evaluate this relationship, we performed a two-sample Mendelian randomization (MR) study.
Material and methods
Summary cheese intake statistics were obtained from UK Biobank and publicly available genome-wide association studies (GWAS) for type 2 diabetes from IEU OpenGWAS, FinnGen Biobank, EBI GWAS, and Biobank Japan. The primary method was pooled meta-analysis with the inverse variance weighting method. The sensitivity analyses included MR-Egger regression, weighted median, weighted mode, and leave-one-out. MR estimations of causation were reported as odds ratios (OR) with 95% confidence intervals (CI).
Results
In the pooled meta-analysis of the fixed and random effect model, the combined ORs for type 2 diabetes were 0.58 (95% CI: 0.50–0.68, p 0.05) but heterogeneity (all p < 0.05).
Conclusions
We found that moderate consumption of beneficial cheese may reduce the risk of type 2 diabetes. These findings suggested that increasing cheese intake appropriate for humans may help prevent and control type 2 diabetes. |
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| ISSN: | 1734-1922 1896-9151 |