Isolation of phytochemicals and exploration the mechanism of Dolichandrone spathacea in the treatment of chronic bronchitis by integrating network pharmacology, molecular docking, and experimental validation

Isolation of phytochemicals and exploration the mechanism of Dolichandrone spathacea in the treatment of chronic bronchitis by integrating network pharmacology, molecular docking, and experimental validation

Abstract Background Dolichandrone spathacea (D. spathacea) is a traditional medicine used to treat chronic bronchitis (CB) in Vietnam and India. However, phytochemicals and potential mechanisms of this species against CB have not been fully illuminated. Therefore, this study aimed to isolate and elu...

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Main Authors: Dang-Khoa Nguyen, Ta-Wei Liu, Man-Hsiu Chu, Quoc-Dung Tran Huynh, Truc-Ly Thi Duong, Thuy-Tien Thi Phan, Duyen Thi My Huynh, Yun-Han Wang, Shu-Mei Wang, Su-Jung Hsu, Ching-Kuo Lee
Format: Article
Language:English
Published: SpringerOpen 2025-08-01
Series:Botanical Studies
Subjects:
Chronic bronchitis
Docking
Isolation
Network pharmacology
Validation
Online Access:https://doi.org/10.1186/s40529-025-00464-0
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