iPSCs: A Minireview from Bench to Bed, including Organoids and the CRISPR System
When Dolly the sheep was born, the first probe into an adult mammalian genome traveling back in time and generating a whole new animal appeared. Ten years later, the reprogramming process became a defined method of producing induced pluripotent stem cells (iPSCs) through the overexpression of four t...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/5934782 |
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| _version_ | 1832565727099355136 |
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| author | Andrés Javier Orqueda Carla Alejandra Giménez Federico Pereyra-Bonnet |
| author_facet | Andrés Javier Orqueda Carla Alejandra Giménez Federico Pereyra-Bonnet |
| author_sort | Andrés Javier Orqueda |
| collection | DOAJ |
| description | When Dolly the sheep was born, the first probe into an adult mammalian genome traveling back in time and generating a whole new animal appeared. Ten years later, the reprogramming process became a defined method of producing induced pluripotent stem cells (iPSCs) through the overexpression of four transcription factors. iPSCs are capable of originating virtually all types of cells and tissues, including a whole new animal. The reprogramming strategies based on patient-derived cells should make the development of clinical applications of cell based therapy much more straightforward. Here, we analyze the current state, opportunities, and challenges of iPSCs from bench to bed, including organoids and the CRISPR system. |
| format | Article |
| id | doaj-art-8a2112c78b524d438e3ce62b26b6a62d |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-8a2112c78b524d438e3ce62b26b6a62d2025-02-03T01:06:52ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/59347825934782iPSCs: A Minireview from Bench to Bed, including Organoids and the CRISPR SystemAndrés Javier Orqueda0Carla Alejandra Giménez1Federico Pereyra-Bonnet2Basic Science and Experimental Medicine Institute, University Institute of the Italian Hospital, Juan D. Perón 4190, C1181ACH Buenos Aires, ArgentinaBasic Science and Experimental Medicine Institute, University Institute of the Italian Hospital, Juan D. Perón 4190, C1181ACH Buenos Aires, ArgentinaBasic Science and Experimental Medicine Institute, University Institute of the Italian Hospital, Juan D. Perón 4190, C1181ACH Buenos Aires, ArgentinaWhen Dolly the sheep was born, the first probe into an adult mammalian genome traveling back in time and generating a whole new animal appeared. Ten years later, the reprogramming process became a defined method of producing induced pluripotent stem cells (iPSCs) through the overexpression of four transcription factors. iPSCs are capable of originating virtually all types of cells and tissues, including a whole new animal. The reprogramming strategies based on patient-derived cells should make the development of clinical applications of cell based therapy much more straightforward. Here, we analyze the current state, opportunities, and challenges of iPSCs from bench to bed, including organoids and the CRISPR system.http://dx.doi.org/10.1155/2016/5934782 |
| spellingShingle | Andrés Javier Orqueda Carla Alejandra Giménez Federico Pereyra-Bonnet iPSCs: A Minireview from Bench to Bed, including Organoids and the CRISPR System Stem Cells International |
| title | iPSCs: A Minireview from Bench to Bed, including Organoids and the CRISPR System |
| title_full | iPSCs: A Minireview from Bench to Bed, including Organoids and the CRISPR System |
| title_fullStr | iPSCs: A Minireview from Bench to Bed, including Organoids and the CRISPR System |
| title_full_unstemmed | iPSCs: A Minireview from Bench to Bed, including Organoids and the CRISPR System |
| title_short | iPSCs: A Minireview from Bench to Bed, including Organoids and the CRISPR System |
| title_sort | ipscs a minireview from bench to bed including organoids and the crispr system |
| url | http://dx.doi.org/10.1155/2016/5934782 |
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