Childhood respiratory risk profiles associate with lung function and COPD among the old population
Background Childhood, often characterized by multiple concurrent risk factors, holds significant influence over long-term respiratory outcomes, with the intricate interplay among these factors representing an intriguing but underexplored avenue for research. We aimed to determine if respiratory risk...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-12-01
|
| Series: | Annals of Medicine |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2025.2470954 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849689358804713472 |
|---|---|
| author | Chenyuan Qin Jian Gao Xingang Sang Min Liu Jue Liu |
| author_facet | Chenyuan Qin Jian Gao Xingang Sang Min Liu Jue Liu |
| author_sort | Chenyuan Qin |
| collection | DOAJ |
| description | Background Childhood, often characterized by multiple concurrent risk factors, holds significant influence over long-term respiratory outcomes, with the intricate interplay among these factors representing an intriguing but underexplored avenue for research. We aimed to determine if respiratory risk factors during childhood affect lung function and chronic obstructive pulmonary disease (COPD) in old age.Methods Participants were drawn from the Health and Retirement Study cohort. Latent class analysis (LCA) was applied with six variables used to develop the early-life respiratory risk profiles. Linear regressions and logistic regressions were used to assess the associations between childhood respiratory risk profiles and lung function, including peak expiratory flow (PEF) value, PEF value <80% of the predicted value and COPD.Results A total of 12,296 participants (5017 males and 7279 females) with an average age of 68 years were recruited. We identified six distinct childhood respiratory risk profiles: (1) ‘Asthma and respiratory disorders in early childhood’ (n = 241, 1.96%), (2) ‘Unexposed or least exposed’ (n = 3874, 31.51%), (3) ‘Smokers at home’ (n = 7609, 61.88%), (4) ‘Ear problems and respiratory disorders in early childhood’ (n = 162, 1.32%), (5) ‘Allergic conditions and respiratory disorders in early childhood’ (n = 220, 1.79%) and (6) ‘Allergic conditions and respiratory disorders in later childhood’ (n = 190, 1.55%). Profile 2 served as the reference. The highest reduction of PEF was seen for profile 1 (–30.07 L/min), followed by profile 6 (–22.24 L/min) and profile 5 (–18.47 L/min). Profile 6, profile 3 and profile 1 related to 1.98-, 1.52- and 1.66-fold increased risks of diminished PEF values, respectively. The highest risk of COPD was observed in profile 5 (aOR = 4.16, 95% CI: 3.75–4.57), followed by profile 6 (aOR = 4.10, 3.69–4.51), profile 4 (aOR = 3.70, 3.25–4.15), profile 1 (aOR = 3.46, 3.07–3.85) and profile 3 (aOR = 1.41, 1.25–1.57).Conclusions People exposed to early-life respiratory challenges experienced larger declines in lung function and increased risks of COPD later in life. Our findings underscore the importance of early-life respiratory health in shaping lung function trajectories. |
| format | Article |
| id | doaj-art-8a20a36a56d046d9a4f97e7bd3b2bc3f |
| institution | DOAJ |
| issn | 0785-3890 1365-2060 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj-art-8a20a36a56d046d9a4f97e7bd3b2bc3f2025-08-20T03:21:39ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602025-12-0157110.1080/07853890.2025.2470954Childhood respiratory risk profiles associate with lung function and COPD among the old populationChenyuan Qin0Jian Gao1Xingang Sang2Min Liu3Jue Liu4School of Public Health, Peking University, Beijing, ChinaPediatric Internal Medicine Department, Weifang Maternal and Child Health Hospital, Weifang, ChinaRecruitment Office, Weifang Municipal Health Commission, Weifang, Shandong, ChinaSchool of Public Health, Peking University, Beijing, ChinaSchool of Public Health, Peking University, Beijing, ChinaBackground Childhood, often characterized by multiple concurrent risk factors, holds significant influence over long-term respiratory outcomes, with the intricate interplay among these factors representing an intriguing but underexplored avenue for research. We aimed to determine if respiratory risk factors during childhood affect lung function and chronic obstructive pulmonary disease (COPD) in old age.Methods Participants were drawn from the Health and Retirement Study cohort. Latent class analysis (LCA) was applied with six variables used to develop the early-life respiratory risk profiles. Linear regressions and logistic regressions were used to assess the associations between childhood respiratory risk profiles and lung function, including peak expiratory flow (PEF) value, PEF value <80% of the predicted value and COPD.Results A total of 12,296 participants (5017 males and 7279 females) with an average age of 68 years were recruited. We identified six distinct childhood respiratory risk profiles: (1) ‘Asthma and respiratory disorders in early childhood’ (n = 241, 1.96%), (2) ‘Unexposed or least exposed’ (n = 3874, 31.51%), (3) ‘Smokers at home’ (n = 7609, 61.88%), (4) ‘Ear problems and respiratory disorders in early childhood’ (n = 162, 1.32%), (5) ‘Allergic conditions and respiratory disorders in early childhood’ (n = 220, 1.79%) and (6) ‘Allergic conditions and respiratory disorders in later childhood’ (n = 190, 1.55%). Profile 2 served as the reference. The highest reduction of PEF was seen for profile 1 (–30.07 L/min), followed by profile 6 (–22.24 L/min) and profile 5 (–18.47 L/min). Profile 6, profile 3 and profile 1 related to 1.98-, 1.52- and 1.66-fold increased risks of diminished PEF values, respectively. The highest risk of COPD was observed in profile 5 (aOR = 4.16, 95% CI: 3.75–4.57), followed by profile 6 (aOR = 4.10, 3.69–4.51), profile 4 (aOR = 3.70, 3.25–4.15), profile 1 (aOR = 3.46, 3.07–3.85) and profile 3 (aOR = 1.41, 1.25–1.57).Conclusions People exposed to early-life respiratory challenges experienced larger declines in lung function and increased risks of COPD later in life. Our findings underscore the importance of early-life respiratory health in shaping lung function trajectories.https://www.tandfonline.com/doi/10.1080/07853890.2025.2470954Respiratory risklung functionlatent class analysispeak expiratory flowCOPDold people |
| spellingShingle | Chenyuan Qin Jian Gao Xingang Sang Min Liu Jue Liu Childhood respiratory risk profiles associate with lung function and COPD among the old population Annals of Medicine Respiratory risk lung function latent class analysis peak expiratory flow COPD old people |
| title | Childhood respiratory risk profiles associate with lung function and COPD among the old population |
| title_full | Childhood respiratory risk profiles associate with lung function and COPD among the old population |
| title_fullStr | Childhood respiratory risk profiles associate with lung function and COPD among the old population |
| title_full_unstemmed | Childhood respiratory risk profiles associate with lung function and COPD among the old population |
| title_short | Childhood respiratory risk profiles associate with lung function and COPD among the old population |
| title_sort | childhood respiratory risk profiles associate with lung function and copd among the old population |
| topic | Respiratory risk lung function latent class analysis peak expiratory flow COPD old people |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2025.2470954 |
| work_keys_str_mv | AT chenyuanqin childhoodrespiratoryriskprofilesassociatewithlungfunctionandcopdamongtheoldpopulation AT jiangao childhoodrespiratoryriskprofilesassociatewithlungfunctionandcopdamongtheoldpopulation AT xingangsang childhoodrespiratoryriskprofilesassociatewithlungfunctionandcopdamongtheoldpopulation AT minliu childhoodrespiratoryriskprofilesassociatewithlungfunctionandcopdamongtheoldpopulation AT jueliu childhoodrespiratoryriskprofilesassociatewithlungfunctionandcopdamongtheoldpopulation |