Protective role of mitophagy on microglia-mediated neuroinflammatory injury through mtDNA-STING signaling in manganese-induced parkinsonism

Protective role of mitophagy on microglia-mediated neuroinflammatory injury through mtDNA-STING signaling in manganese-induced parkinsonism

Abstract Manganese (Mn), the third most abundant transition metal in the earth’s crust, has widespread applications in the emerging field of organometallic catalysis and traditional industries. Excessive Mn exposure causes neurological syndrome resembling Parkinson’s disease (PD). The pathogenesis o...

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Bibliographic Details
Main Authors: Yang Lu, Liang Gao, Yuqing Yang, Dihang Shi, Zhipeng Zhang, Xiaobai Wang, Ying Huang, Jie Wu, Jia Meng, Hong Li, Dongying Yan
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Journal of Neuroinflammation
Subjects:
Manganese
Neuroinflammation
Microglia
Mitophagy
STING
Online Access:https://doi.org/10.1186/s12974-025-03396-5
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