Surgical Approach and Laser Applications in BRONJ Osteoporotic and Cancer Patients
Bisphosphonates-related Osteonecrosis of the Jaw (BRONJ) has been reported with increasing frequency in literature over last years, but its therapy is still a dilemma. One hundred ninety patients affected by BRONJ were observed between January 2004 and November 2011 and 166 treated sites were subdi...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Journal of Osteoporosis |
| Online Access: | http://dx.doi.org/10.1155/2012/585434 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832550015118082048 |
|---|---|
| author | Paolo Vescovi Elisabetta Merigo Marco Meleti Maddalena Manfredi Carlo Fornaini Samir Nammour |
| author_facet | Paolo Vescovi Elisabetta Merigo Marco Meleti Maddalena Manfredi Carlo Fornaini Samir Nammour |
| author_sort | Paolo Vescovi |
| collection | DOAJ |
| description | Bisphosphonates-related Osteonecrosis of the Jaw (BRONJ) has been reported with increasing frequency in literature over last years, but its therapy is still a dilemma. One hundred ninety patients affected by BRONJ were observed between January 2004 and November 2011 and 166 treated sites were subdivided in five groups on the basis of the therapeutical approach (medical or surgical, traditional or laser-assisted approach, with or without Low Level Laser Therapy (LLLT)). Clinical success has been defined for each treatment performed as clinical improvement or complete mucosal healing. Combination of antibiotic therapy, conservative surgery performed with Er:YAG laser and LLLT applications showed best results for cancer and noncancer patients. Nonsurgical approach performed on 69 sites induced an improvement in 35 sites (50.7%) and the complete healing in 19 sites (27.5%), while surgical approach on 97 sites induced an improvement in 84 sites (86.6%) and the complete healing in 78 sites (80.41%). Improvement and healing were recorded in 31 (81.5%) and 27 (71.5%) out of the 38 BRONJ sites treated in noncancer patients and in 88 (68.75%) and in 69 (53.9%) out of the 128 in cancer patients. |
| format | Article |
| id | doaj-art-8a0b051a52334040ad088655076dbec1 |
| institution | Kabale University |
| issn | 2090-8059 2042-0064 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Osteoporosis |
| spelling | doaj-art-8a0b051a52334040ad088655076dbec12025-02-03T06:08:01ZengWileyJournal of Osteoporosis2090-80592042-00642012-01-01201210.1155/2012/585434585434Surgical Approach and Laser Applications in BRONJ Osteoporotic and Cancer PatientsPaolo Vescovi0Elisabetta Merigo1Marco Meleti2Maddalena Manfredi3Carlo Fornaini4Samir Nammour5Oral Medicine, Pathology and Laser-Assisted Surgery Unit and Section of Dentistry, Department of ENT/Dental/Ophthalmological and Cervico-Facial Sciences, University of Parma, Via Gramsci, 14-43100 Parma, ItalyOral Medicine, Pathology and Laser-Assisted Surgery Unit and Section of Dentistry, Department of ENT/Dental/Ophthalmological and Cervico-Facial Sciences, University of Parma, Via Gramsci, 14-43100 Parma, ItalyOral Medicine, Pathology and Laser-Assisted Surgery Unit and Section of Dentistry, Department of ENT/Dental/Ophthalmological and Cervico-Facial Sciences, University of Parma, Via Gramsci, 14-43100 Parma, ItalyOral Medicine, Pathology and Laser-Assisted Surgery Unit and Section of Dentistry, Department of ENT/Dental/Ophthalmological and Cervico-Facial Sciences, University of Parma, Via Gramsci, 14-43100 Parma, ItalyOral Medicine, Pathology and Laser-Assisted Surgery Unit and Section of Dentistry, Department of ENT/Dental/Ophthalmological and Cervico-Facial Sciences, University of Parma, Via Gramsci, 14-43100 Parma, ItalyEuropean Master Degree in Oral Laser Applications (EMDOLA), University of Liège, Boulevard de la Constitution, 78-4020 Liège, BelgiumBisphosphonates-related Osteonecrosis of the Jaw (BRONJ) has been reported with increasing frequency in literature over last years, but its therapy is still a dilemma. One hundred ninety patients affected by BRONJ were observed between January 2004 and November 2011 and 166 treated sites were subdivided in five groups on the basis of the therapeutical approach (medical or surgical, traditional or laser-assisted approach, with or without Low Level Laser Therapy (LLLT)). Clinical success has been defined for each treatment performed as clinical improvement or complete mucosal healing. Combination of antibiotic therapy, conservative surgery performed with Er:YAG laser and LLLT applications showed best results for cancer and noncancer patients. Nonsurgical approach performed on 69 sites induced an improvement in 35 sites (50.7%) and the complete healing in 19 sites (27.5%), while surgical approach on 97 sites induced an improvement in 84 sites (86.6%) and the complete healing in 78 sites (80.41%). Improvement and healing were recorded in 31 (81.5%) and 27 (71.5%) out of the 38 BRONJ sites treated in noncancer patients and in 88 (68.75%) and in 69 (53.9%) out of the 128 in cancer patients.http://dx.doi.org/10.1155/2012/585434 |
| spellingShingle | Paolo Vescovi Elisabetta Merigo Marco Meleti Maddalena Manfredi Carlo Fornaini Samir Nammour Surgical Approach and Laser Applications in BRONJ Osteoporotic and Cancer Patients Journal of Osteoporosis |
| title | Surgical Approach and Laser Applications in BRONJ Osteoporotic and Cancer Patients |
| title_full | Surgical Approach and Laser Applications in BRONJ Osteoporotic and Cancer Patients |
| title_fullStr | Surgical Approach and Laser Applications in BRONJ Osteoporotic and Cancer Patients |
| title_full_unstemmed | Surgical Approach and Laser Applications in BRONJ Osteoporotic and Cancer Patients |
| title_short | Surgical Approach and Laser Applications in BRONJ Osteoporotic and Cancer Patients |
| title_sort | surgical approach and laser applications in bronj osteoporotic and cancer patients |
| url | http://dx.doi.org/10.1155/2012/585434 |
| work_keys_str_mv | AT paolovescovi surgicalapproachandlaserapplicationsinbronjosteoporoticandcancerpatients AT elisabettamerigo surgicalapproachandlaserapplicationsinbronjosteoporoticandcancerpatients AT marcomeleti surgicalapproachandlaserapplicationsinbronjosteoporoticandcancerpatients AT maddalenamanfredi surgicalapproachandlaserapplicationsinbronjosteoporoticandcancerpatients AT carlofornaini surgicalapproachandlaserapplicationsinbronjosteoporoticandcancerpatients AT samirnammour surgicalapproachandlaserapplicationsinbronjosteoporoticandcancerpatients |