Synthesis and In Vitro Antioxidant Evaluation of Some Novel 4, 5-Dihydro-1H, 2, 4-triazol-5-one Derivatives
In this study, thirteen novel 4,5-dihydro-1H-1,2,4-triazol-5-one derivatives were synthesized and characterized by elemental analyses and IR, 1H NMR,13C NMR and UV spectral data. The synthesized compounds were analyzed for their in vitro potential antioxidant activities in three different methods. T...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2010/407603 |
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| author | O. Gursoy Kol H. Yuksek |
| author_facet | O. Gursoy Kol H. Yuksek |
| author_sort | O. Gursoy Kol |
| collection | DOAJ |
| description | In this study, thirteen novel 4,5-dihydro-1H-1,2,4-triazol-5-one derivatives were synthesized and characterized by elemental analyses and IR, 1H NMR,13C NMR and UV spectral data. The synthesized compounds were analyzed for their in vitro potential antioxidant activities in three different methods. Those antioxidant activities were compared to standard antioxidants such as BHA, BHT and α-tocopherol. The data reveal that the compounds demonstrate a marked capacity for iron binding, especially 5a and 7c In addition to this, the compounds 4 were titrated potentiometrically with TBAH in non-aqueous solvents because of the weak acidic properties of 4,5-dihydro-1H-1,2,4-triazol-5-one ring N-H group. |
| format | Article |
| id | doaj-art-8a01472973be42839104fffaa2fe5b57 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-8a01472973be42839104fffaa2fe5b572025-02-03T05:58:54ZengWileyE-Journal of Chemistry0973-49452090-98102010-01-017112313610.1155/2010/407603Synthesis and In Vitro Antioxidant Evaluation of Some Novel 4, 5-Dihydro-1H, 2, 4-triazol-5-one DerivativesO. Gursoy Kol0H. Yuksek1Department of Chemistry, Kafkas University, 36100 Kars, TurkeyDepartment of Chemistry, Kafkas University, 36100 Kars, TurkeyIn this study, thirteen novel 4,5-dihydro-1H-1,2,4-triazol-5-one derivatives were synthesized and characterized by elemental analyses and IR, 1H NMR,13C NMR and UV spectral data. The synthesized compounds were analyzed for their in vitro potential antioxidant activities in three different methods. Those antioxidant activities were compared to standard antioxidants such as BHA, BHT and α-tocopherol. The data reveal that the compounds demonstrate a marked capacity for iron binding, especially 5a and 7c In addition to this, the compounds 4 were titrated potentiometrically with TBAH in non-aqueous solvents because of the weak acidic properties of 4,5-dihydro-1H-1,2,4-triazol-5-one ring N-H group.http://dx.doi.org/10.1155/2010/407603 |
| spellingShingle | O. Gursoy Kol H. Yuksek Synthesis and In Vitro Antioxidant Evaluation of Some Novel 4, 5-Dihydro-1H, 2, 4-triazol-5-one Derivatives E-Journal of Chemistry |
| title | Synthesis and In Vitro Antioxidant Evaluation of Some Novel 4, 5-Dihydro-1H, 2, 4-triazol-5-one Derivatives |
| title_full | Synthesis and In Vitro Antioxidant Evaluation of Some Novel 4, 5-Dihydro-1H, 2, 4-triazol-5-one Derivatives |
| title_fullStr | Synthesis and In Vitro Antioxidant Evaluation of Some Novel 4, 5-Dihydro-1H, 2, 4-triazol-5-one Derivatives |
| title_full_unstemmed | Synthesis and In Vitro Antioxidant Evaluation of Some Novel 4, 5-Dihydro-1H, 2, 4-triazol-5-one Derivatives |
| title_short | Synthesis and In Vitro Antioxidant Evaluation of Some Novel 4, 5-Dihydro-1H, 2, 4-triazol-5-one Derivatives |
| title_sort | synthesis and in vitro antioxidant evaluation of some novel 4 5 dihydro 1h 2 4 triazol 5 one derivatives |
| url | http://dx.doi.org/10.1155/2010/407603 |
| work_keys_str_mv | AT ogursoykol synthesisandinvitroantioxidantevaluationofsomenovel45dihydro1h24triazol5onederivatives AT hyuksek synthesisandinvitroantioxidantevaluationofsomenovel45dihydro1h24triazol5onederivatives |