Treatment of Steroid and Cyclosporine-Resistant Idiopathic Nephrotic Syndrome in Children
Steroid-resistant nephrotic syndrome (SRNS) in children carries a significant risk of progression to end-stage renal failure (ESRF). We report a two-step protocol adapted in children with SRNS. Thirty-seven SRNS were treated with cyclosporine A (CyA) in association with prednisolone (alternate day)...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.4061/2011/930965 |
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| author | A. A. Nikibakhsh H. Mahmoodzadeh M. Karamyyar S. Hejazi M. Noroozi A. A. Macooie |
| author_facet | A. A. Nikibakhsh H. Mahmoodzadeh M. Karamyyar S. Hejazi M. Noroozi A. A. Macooie |
| author_sort | A. A. Nikibakhsh |
| collection | DOAJ |
| description | Steroid-resistant nephrotic syndrome (SRNS) in children carries a significant risk of progression to end-stage renal failure (ESRF). We report a two-step protocol adapted in children with SRNS. Thirty-seven SRNS were treated with cyclosporine A (CyA) in association with prednisolone (alternate day) for 6 months (first-step treatment). Twelve patients (32.4%) went into complete remission, and 2 (5.4%) got partial remission.
The other 23 cases who were steroid and CyA resistant entered a second-step treatment with withdrawing steroids, with CyA (5 mg/kg/day) in association with mycophenolate mofetil (MMF) 30 mg/kg/day for 6 months. Complete remission was observed in 11 cases (47.82%) and partial remission in 2 cases (8.7%).
After two steps of treatment, 27/37 children went into total remission. In steroid and CyA-resistant INS, the association of MMF with CyA was able to induce remission in about half cases without relevant side effects. |
| format | Article |
| id | doaj-art-89fced0477314fe78d462de0cf0c2453 |
| institution | Kabale University |
| issn | 2090-214X 2090-2158 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-89fced0477314fe78d462de0cf0c24532025-02-03T05:53:49ZengWileyInternational Journal of Nephrology2090-214X2090-21582011-01-01201110.4061/2011/930965930965Treatment of Steroid and Cyclosporine-Resistant Idiopathic Nephrotic Syndrome in ChildrenA. A. Nikibakhsh0H. Mahmoodzadeh1M. Karamyyar2S. Hejazi3M. Noroozi4A. A. Macooie5Urology-Nephrology and Transplantation Research Centre, Department of Paediatric Nephrology, Urmia University School of Medicine, IranSchool of Medicine, Urmia University, IranSchool of Medicine, Urmia University, IranSchool of Medicine, Urmia University, IranSchool of Medicine, Urmia University, IranSchool of Medicine, Urmia University, IranSteroid-resistant nephrotic syndrome (SRNS) in children carries a significant risk of progression to end-stage renal failure (ESRF). We report a two-step protocol adapted in children with SRNS. Thirty-seven SRNS were treated with cyclosporine A (CyA) in association with prednisolone (alternate day) for 6 months (first-step treatment). Twelve patients (32.4%) went into complete remission, and 2 (5.4%) got partial remission. The other 23 cases who were steroid and CyA resistant entered a second-step treatment with withdrawing steroids, with CyA (5 mg/kg/day) in association with mycophenolate mofetil (MMF) 30 mg/kg/day for 6 months. Complete remission was observed in 11 cases (47.82%) and partial remission in 2 cases (8.7%). After two steps of treatment, 27/37 children went into total remission. In steroid and CyA-resistant INS, the association of MMF with CyA was able to induce remission in about half cases without relevant side effects.http://dx.doi.org/10.4061/2011/930965 |
| spellingShingle | A. A. Nikibakhsh H. Mahmoodzadeh M. Karamyyar S. Hejazi M. Noroozi A. A. Macooie Treatment of Steroid and Cyclosporine-Resistant Idiopathic Nephrotic Syndrome in Children International Journal of Nephrology |
| title | Treatment of Steroid and Cyclosporine-Resistant Idiopathic Nephrotic Syndrome in Children |
| title_full | Treatment of Steroid and Cyclosporine-Resistant Idiopathic Nephrotic Syndrome in Children |
| title_fullStr | Treatment of Steroid and Cyclosporine-Resistant Idiopathic Nephrotic Syndrome in Children |
| title_full_unstemmed | Treatment of Steroid and Cyclosporine-Resistant Idiopathic Nephrotic Syndrome in Children |
| title_short | Treatment of Steroid and Cyclosporine-Resistant Idiopathic Nephrotic Syndrome in Children |
| title_sort | treatment of steroid and cyclosporine resistant idiopathic nephrotic syndrome in children |
| url | http://dx.doi.org/10.4061/2011/930965 |
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