Pathological Laughter as a Symptom of Midbrain Infarction
Pathological laughter is an uncommon symptom usually caused by bilateral, diffuse cerebral lesions. It has rarely been reported in association with isolated cerebral lesions. Midbrain involvement causing pathological laughter is extremely unusual. We describe three patients who developed pathologica...
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| Format: | Article |
| Language: | English |
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Wiley
2004-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2004/409248 |
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| author | Ron Dabby Nathan Watemberg Yair Lampl Anda Eilam Abraham Rapaport Menachem Sadeh |
| author_facet | Ron Dabby Nathan Watemberg Yair Lampl Anda Eilam Abraham Rapaport Menachem Sadeh |
| author_sort | Ron Dabby |
| collection | DOAJ |
| description | Pathological laughter is an uncommon symptom usually caused by bilateral, diffuse cerebral lesions. It has rarely been reported in association with isolated cerebral lesions. Midbrain involvement causing pathological laughter is extremely unusual. We describe three patients who developed pathological laughter after midbrain and pontine-midbrain infarction. In two patients a small infarction in the left paramedian midbrain was detected, whereas the third one sustained a massive bilateral pontine infarction extending to the midbrain. Laughter heralded stroke by one day in one patient and occurred as a delayed phenomenon three months after stroke in another. Pathological laughter ceased within a few days in two patients and was still present at a two year follow-up in the patient with delayed-onset laughter. Pathological laughter can herald midbrain infarction or follow stroke either shortly after onset of symptoms or as a delayed phenomenon. Furthermore, small unilateral midbrain infarctions can cause this rare complication. |
| format | Article |
| id | doaj-art-89fa94fe609646cb868c1ada24812cd0 |
| institution | Kabale University |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2004-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-89fa94fe609646cb868c1ada24812cd02025-02-03T01:25:43ZengWileyBehavioural Neurology0953-41801875-85842004-01-01153-4737610.1155/2004/409248Pathological Laughter as a Symptom of Midbrain InfarctionRon Dabby0Nathan Watemberg1Yair Lampl2Anda Eilam3Abraham Rapaport4Menachem Sadeh5Department of Neurology, Edith Wolfson Medical Center, Holon 58100, Israel Affiliated to Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelPediatric Neurology Unit, Edith Wolfson Medical Center, Holon 58100, Israel Affiliated to Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelDepartment of Neurology, Edith Wolfson Medical Center, Holon 58100, Israel Affiliated to Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelDepartment of Neurology, Edith Wolfson Medical Center, Holon 58100, Israel Affiliated to Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelDepartment of Neurology, Edith Wolfson Medical Center, Holon 58100, Israel Affiliated to Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelDepartment of Neurology, Edith Wolfson Medical Center, Holon 58100, Israel Affiliated to Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelPathological laughter is an uncommon symptom usually caused by bilateral, diffuse cerebral lesions. It has rarely been reported in association with isolated cerebral lesions. Midbrain involvement causing pathological laughter is extremely unusual. We describe three patients who developed pathological laughter after midbrain and pontine-midbrain infarction. In two patients a small infarction in the left paramedian midbrain was detected, whereas the third one sustained a massive bilateral pontine infarction extending to the midbrain. Laughter heralded stroke by one day in one patient and occurred as a delayed phenomenon three months after stroke in another. Pathological laughter ceased within a few days in two patients and was still present at a two year follow-up in the patient with delayed-onset laughter. Pathological laughter can herald midbrain infarction or follow stroke either shortly after onset of symptoms or as a delayed phenomenon. Furthermore, small unilateral midbrain infarctions can cause this rare complication.http://dx.doi.org/10.1155/2004/409248 |
| spellingShingle | Ron Dabby Nathan Watemberg Yair Lampl Anda Eilam Abraham Rapaport Menachem Sadeh Pathological Laughter as a Symptom of Midbrain Infarction Behavioural Neurology |
| title | Pathological Laughter as a Symptom of Midbrain Infarction |
| title_full | Pathological Laughter as a Symptom of Midbrain Infarction |
| title_fullStr | Pathological Laughter as a Symptom of Midbrain Infarction |
| title_full_unstemmed | Pathological Laughter as a Symptom of Midbrain Infarction |
| title_short | Pathological Laughter as a Symptom of Midbrain Infarction |
| title_sort | pathological laughter as a symptom of midbrain infarction |
| url | http://dx.doi.org/10.1155/2004/409248 |
| work_keys_str_mv | AT rondabby pathologicallaughterasasymptomofmidbraininfarction AT nathanwatemberg pathologicallaughterasasymptomofmidbraininfarction AT yairlampl pathologicallaughterasasymptomofmidbraininfarction AT andaeilam pathologicallaughterasasymptomofmidbraininfarction AT abrahamrapaport pathologicallaughterasasymptomofmidbraininfarction AT menachemsadeh pathologicallaughterasasymptomofmidbraininfarction |